{"description":"Documents matching 'mitragynine' and published on or after 07/01/2026","count":4,"total_pages":1,"results":[{"title":"Schedules of Controlled Substances: Temporary Placement of Mitragynine Pseudoindoxyl, MGM-15, and MGM-16 in Schedule I","type":"Rule","abstract":"The Drug Enforcement Administration (DEA) is issuing this temporary order to schedule three 7-hydroxymitragynine-related substances (mitragynine pseudoindoxyl, MGM-15, and MGM-16), including their isomers, esters, ethers, salts, and salts of isomers, esters, and ethers, whenever the existence of such isomers, esters, ethers, and salts is possible, in schedule I of the Controlled Substances Act. DEA bases this action on a finding that placing mitragynine pseudoindoxyl, MGM-15, and MGM-16 in schedule I is necessary to avoid an imminent hazard to public safety. This order imposes the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances on persons who handle (manufacture, distribute, reverse distribute, import, export, engage in research, conduct instructional activities or chemical analysis with, or possess) or propose to handle these three 7-hydroxymitragynine-related substances.","document_number":"2026-17429","html_url":"https://www.federalregister.gov/documents/2026/08/26/2026-17429/schedules-of-controlled-substances-temporary-placement-of-mitragynine-pseudoindoxyl-mgm-15-and","pdf_url":"https://www.govinfo.gov/content/pkg/FR-2026-08-26/pdf/2026-17429.pdf","public_inspection_pdf_url":"https://public-inspection.federalregister.gov/2026-17429.pdf?1787602521","publication_date":"2026-08-26","agencies":[{"raw_name":"DEPARTMENT OF JUSTICE","name":"Justice Department","id":268,"url":"https://www.federalregister.gov/agencies/justice-department","json_url":"https://www.federalregister.gov/api/v1/agencies/268","parent_id":null,"slug":"justice-department"},{"raw_name":"Drug Enforcement Administration","name":"Drug Enforcement Administration","id":116,"url":"https://www.federalregister.gov/agencies/drug-enforcement-administration","json_url":"https://www.federalregister.gov/api/v1/agencies/116","parent_id":268,"slug":"drug-enforcement-administration"}],"excerpts":"History and Current Pattern of Abuse \n \n <span class=\"match\">Mitragynine</span> pseudoindoxyl, MGM-15, and MGM-16 are synthetic derivatives of the indole alkaloids, <span class=\"match\">mitragynine</span> or 7-hydroxymitragynine, of the \n Mitragyna speciosa \n plant. Unlike the indole alkaloids <span class=\"match\">mitragynine</span> and 7-hydroxymitragynine, which are naturally occurring in the plant, <span class=\"match\">mitragynine</span> pseudoindoxyl, MGM-15, \n \n and MGM-16 are produced through synthetic modifications of purified <span class=\"match\">mitragynine</span> isolates or 7-hydroxymitragynine.\n 19 \n \n The chemical scaffolds of <span class=\"match\">mitragynine</span> or 7-hydroxymitragynine were used in"},{"title":"Schedules of Controlled Substances: Temporary Placement of Mitragynine Pseudoindoxyl, MGM-15, and MGM-16 in Schedule I","type":"Proposed Rule","abstract":"The Administrator of the Drug Enforcement Administration is issuing this notice of intent to publish a temporary order to schedule three 7-hydroxymitragynine-related substances (mitragynine pseudoindoxyl, MGM-15, and MGM-16), including their isomers, esters, ethers, salts, and salts of isomers, esters, and ethers, whenever the existence of such isomers, esters, ethers, and salts is possible, in schedule I of the Controlled Substances Act. When it is issued, the temporary scheduling order will impose the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances on persons who handle (manufacture, distribute, reverse distribute, import, export, engage in research, conduct instructional activities or chemical analysis with, or possess) or propose to handle these three 7-hydroxymitragynine-related substances.","document_number":"2026-13581","html_url":"https://www.federalregister.gov/documents/2026/07/06/2026-13581/schedules-of-controlled-substances-temporary-placement-of-mitragynine-pseudoindoxyl-mgm-15-and","pdf_url":"https://www.govinfo.gov/content/pkg/FR-2026-07-06/pdf/2026-13581.pdf","public_inspection_pdf_url":"https://public-inspection.federalregister.gov/2026-13581.pdf?1782936911","publication_date":"2026-07-06","agencies":[{"raw_name":"DEPARTMENT OF JUSTICE","name":"Justice Department","id":268,"url":"https://www.federalregister.gov/agencies/justice-department","json_url":"https://www.federalregister.gov/api/v1/agencies/268","parent_id":null,"slug":"justice-department"},{"raw_name":"Drug Enforcement Administration","name":"Drug Enforcement Administration","id":116,"url":"https://www.federalregister.gov/agencies/drug-enforcement-administration","json_url":"https://www.federalregister.gov/api/v1/agencies/116","parent_id":268,"slug":"drug-enforcement-administration"}],"excerpts":"History and Current Pattern of Abuse \n \n <span class=\"match\">Mitragynine</span> pseudoindoxyl, MGM-15, and MGM-16 are synthetic derivatives of the indole alkaloids, <span class=\"match\">mitragynine</span> or 7-hydroxymitragynine, of the \n Mitragyna speciosa \n plant. Unlike the indole alkaloids <span class=\"match\">mitragynine</span> and 7-hydroxymitragynine, which are naturally occurring in the plant, <span class=\"match\">mitragynine</span> pseudoindoxyl, MGM-15, and MGM-16 are produced through synthetic modifications of purified <span class=\"match\">mitragynine</span> isolates or 7-hydroxymitragynine.\n 18 \n \n The chemical scaffolds of <span class=\"match\">mitragynine</span> or 7-hydroxymitragynine were used in scientific"},{"title":"Schedules of Controlled Substance: Temporary Placement of 7-Hydroxymitragynine Above a Specified Threshold in Schedule I","type":"Proposed Rule","abstract":"The Administrator of the Drug Enforcement Administration is issuing this notice of intent to publish a temporary order to schedule 7-hydroxymitragynine above a specified threshold, including its isomers, esters, ethers, salts, and salts of isomers, esters, and ethers, whenever the existence of such isomers, esters, ethers, and salts is possible, in schedule I of the Controlled Substances Act. When it is issued, the temporary scheduling order will impose the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances on persons who handle (manufacture, distribute, reverse distribute, import, export, engage in research, conduct instructional activities or chemical analysis with, or possess) or propose to handle 7-hydroxymitragynine above a specified threshold.","document_number":"2026-13580","html_url":"https://www.federalregister.gov/documents/2026/07/06/2026-13580/schedules-of-controlled-substance-temporary-placement-of-7-hydroxymitragynine-above-a-specified","pdf_url":"https://www.govinfo.gov/content/pkg/FR-2026-07-06/pdf/2026-13580.pdf","public_inspection_pdf_url":"https://public-inspection.federalregister.gov/2026-13580.pdf?1782936911","publication_date":"2026-07-06","agencies":[{"raw_name":"DEPARTMENT OF JUSTICE","name":"Justice Department","id":268,"url":"https://www.federalregister.gov/agencies/justice-department","json_url":"https://www.federalregister.gov/api/v1/agencies/268","parent_id":null,"slug":"justice-department"},{"raw_name":"Drug Enforcement Administration","name":"Drug Enforcement Administration","id":116,"url":"https://www.federalregister.gov/agencies/drug-enforcement-administration","json_url":"https://www.federalregister.gov/api/v1/agencies/116","parent_id":268,"slug":"drug-enforcement-administration"}],"excerpts":"identified in \n M. speciosa, \n the indole alkaloids <span class=\"match\">mitragynine</span> (major) and 7-hydroxymitragynine (minor) are primarily responsible for the plant's psychoactive effects. In its natural botanical form, 7-hydroxymitragynine makes up less than two percent of the total alkaloid content or occurs in trace amount in \n M. speciosa. \n However, 7-hydroxymitragynine can be synthesized from <span class=\"match\">mitragynine</span> through a one-step chemical reaction, and it also exists as an active oxidized metabolite of <span class=\"match\">mitragynine</span> \n in vivo. \n Despite the different origins of 7-hydroxymitragynine"},{"title":"Schedules of Controlled Substances: Temporary Placement of O-Desmethyltramadol in Schedule I","type":"Rule","abstract":"The Drug Enforcement Administration issues this temporary order to schedule O-desmethyltramadol (other names: O-DSMT; desmetramadol; 3-[(1R,2R)-2-[(dimethylamino)methyl]-1- hydroxycyclohexyl]phenol), including its isomers, esters, ethers, salts, and salts of isomers, esters and ethers, in schedule I of the Controlled Substances Act. DEA bases this action on a finding that placing O-DSMT in schedule I is necessary to avoid an imminent hazard to public safety. This order imposes the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances on persons who handle (manufacture, distribute, reverse distribute, import, export, engage in research, conduct instructional activities or chemical analysis with, or possess) or propose to handle O-DSMT.","document_number":"2026-16413","html_url":"https://www.federalregister.gov/documents/2026/08/12/2026-16413/schedules-of-controlled-substances-temporary-placement-of-o-desmethyltramadol-in-schedule-i","pdf_url":"https://www.govinfo.gov/content/pkg/FR-2026-08-12/pdf/2026-16413.pdf","public_inspection_pdf_url":"https://public-inspection.federalregister.gov/2026-16413.pdf?1786452314","publication_date":"2026-08-12","agencies":[{"raw_name":"DEPARTMENT OF JUSTICE","name":"Justice Department","id":268,"url":"https://www.federalregister.gov/agencies/justice-department","json_url":"https://www.federalregister.gov/api/v1/agencies/268","parent_id":null,"slug":"justice-department"},{"raw_name":"Drug Enforcement Administration","name":"Drug Enforcement Administration","id":116,"url":"https://www.federalregister.gov/agencies/drug-enforcement-administration","json_url":"https://www.federalregister.gov/api/v1/agencies/116","parent_id":268,"slug":"drug-enforcement-administration"}],"excerpts":"Three-factor analysis at \n www.regulations.gov \n under Docket Number DEA-1641.\n \n \n In 2009, reports in Sweden described nine deaths due to intoxication with \n O \n -DSMT combined with <span class=\"match\">mitragynine</span> and confirmed via forensic autopsies. Occurring between October 2009 and October 2010, ten forensic medical investigations found concomitant use of \n O \n -DSMT and <span class=\"match\">mitragynine</span> in the blood of these deceased individuals. It was noted that in nine of these cases, the death was explained by intoxication with \n O \n -DSMT. Other substances were identified, but"}]}