{"abstract":"The Food and Drug Administration (FDA) is announcing the availability of the cumulative list of orphan drug and biological designations as of December 31, 1999. FDA has announced the availability of previous lists, which are updated monthly, identifying the drugs and biologicals granted orphan designation under the Federal Food, Drug, and Cosmetic Act (the act).","action":"Notice.","agencies":[{"raw_name":"DEPARTMENT OF HEALTH AND HUMAN SERVICES","name":"Health and Human Services Department","id":221,"url":"https://www.federalregister.gov/agencies/health-and-human-services-department","json_url":"https://www.federalregister.gov/api/v1/agencies/221","parent_id":null,"slug":"health-and-human-services-department"},{"raw_name":"Food and Drug Administration","name":"Food and Drug Administration","id":199,"url":"https://www.federalregister.gov/agencies/food-and-drug-administration","json_url":"https://www.federalregister.gov/api/v1/agencies/199","parent_id":221,"slug":"food-and-drug-administration"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2000/03/01/00-4875.html","cfr_references":[],"citation":"65 FR 11066","comment_url":null,"comments_close_on":null,"correction_of":null,"corrections":[],"dates":null,"disposition_notes":null,"docket_ids":["Docket No. 84N-0102"],"dockets":[],"document_number":"00-4875","effective_on":null,"end_page":11066,"executive_order_notes":null,"executive_order_number":null,"explanation":null,"full_text_xml_url":"https://www.federalregister.gov/documents/full_text/xml/2000/03/01/00-4875.xml","html_url":"https://www.federalregister.gov/documents/2000/03/01/00-4875/cumulative-list-of-orphan-drug-and-biological-designations","images":{},"images_metadata":{},"json_url":"https://www.federalregister.gov/api/v1/documents/00-4875?publication_date=2000-03-01","mods_url":"https://www.govinfo.gov/metadata/granule/FR-2000-03-01/00-4875/mods.xml","not_received_for_publication":null,"page_length":1,"page_views":{"count":43,"last_updated":"2026-04-04 12:15:04 -0400"},"pdf_url":"https://www.govinfo.gov/content/pkg/FR-2000-03-01/pdf/00-4875.pdf","presidential_document_number":null,"proclamation_number":null,"public_inspection_pdf_url":null,"publication_date":"2000-03-01","raw_text_url":"https://www.federalregister.gov/documents/full_text/text/2000/03/01/00-4875.txt","regulation_id_number_info":{},"regulation_id_numbers":[],"regulations_dot_gov_info":{},"regulations_dot_gov_url":null,"significant":null,"signing_date":null,"start_page":11066,"subtype":null,"title":"Cumulative List of Orphan Drug and Biological Designations","toc_doc":null,"toc_subject":null,"topics":[],"type":"Notice","volume":65}