{"abstract":null,"action":null,"agencies":[{"raw_name":"DEPARTMENT OF JUSTICE","name":"Justice Department","id":268,"url":"https://www.federalregister.gov/agencies/justice-department","json_url":"https://www.federalregister.gov/api/v1/agencies/268","parent_id":null,"slug":"justice-department"},{"raw_name":"Drug Enforcement Administration","name":"Drug Enforcement Administration","id":116,"url":"https://www.federalregister.gov/agencies/drug-enforcement-administration","json_url":"https://www.federalregister.gov/api/v1/agencies/116","parent_id":268,"slug":"drug-enforcement-administration"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2001/04/18/01-9306.html","cfr_references":[],"citation":"66 FR 20038","comment_url":null,"comments_close_on":null,"correction_of":null,"corrections":[],"dates":"July 2000, Edition Desc: 4th Edition--Text Revision. Dewey, W. L., Martin, B. R., May, E. L. Cannabinoid stereoisomers: pharmacological effects. In Smith, D. F. (Ed.) CRC Handbook of stereoisomers: drugs in psychopharmacology, 317-326 (Boca Raton, FL, CRC Press), 1984. Fried, P. A., Watkinson, B. 36- and 48-month neurobehabioral follow- up of children prenatally exposed to marijuana, cigarettes and alcohol. J. Dev. Behav. Pediatr. 1987, 8, 318-326. Fried, P. A., Watkinson, B., Gray, R. A follow-up study of attentional behavior in 6-year-old children exposed prenatally to marihuana, cigarettes and alcohol. Neurotoxicol. Teratol. 1992, 14, 299-311. Fried, P. A., Watkinson, B., Gray, R. Differential effects on cognitive functioning in 9- to 12-year olds prenatally exposed to cigarettes and marihuana. Neurotoxicol. Teratol. 1998, 20(3), 293- 306. French, E.D. Delta\\9\\-Tetrahydrocannabinol excites rat VTA dopamine neurons through activation of cannabinoid CB1 but not opioid receptors. Neurosci Lett 1997, 226, 159-162. Fung, M., Gallagher, C., Machtay, M. Lung and aeo-digestive cancers in young marijuana smokers. Tumori 1999, 85 (2), 140-142. Galiegui, S.; Mary, S.; Marchand, J.; Dussossoy, D.; Carriere, D.; Carayon, P.; Bouaboula, M; Shire, D.; Le Fur, g.; Casellas, P. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem. 1995, 232(1), 54-61. Gaoni, Y., Mechoulam, R. Isolation, structure, and partial synthesis of an active constituent of hashish. J. Am. Chem. Soc. 1964, 86, 1646-1947. Gerard, C. M., Mollereau, C., Vassart, G., Parmentier, M. Molecular cloning of a human cannabinoid receptor which is also expressed in testis. : Biochem J. 1991, 279, 129-34. Gessa, G.L., Melis, M., Munoni, A.L., Diana, M. Cannabinoids activate mesolimbic dopamine neurons by an action on cannabinoid CB1 receptors. Eur J Pharmacol 1998, 341(1), 39-44. Graham, J.D.P., ed. Cannabis and Health. New York: Academic Press, 1976. Griffith, D. R., Azuma, S. D., Chasnoff, I. J. Three-year outcome of children exposed prenatally to drugs. J. Am. Acad. Child Adolesc. Psychiatry 1994, 33, 20-27. Haney M, Ward AS, Comer SD, Foltin RW, Fischman MW. Abstinence symptoms following smoked marijuana in humans. Psychopharmacology (Berl) 1999, 141(4):395-404. Hanus, L., Breuer, A., Tchilibon, S., Shiloah, S., Goldenberg, D., Horowitz, M., Pertwee, R.G., Roos, R. A., Mechoulam, R., Fride, E. HU-308: a specific agonist for CB(2), a peripheral Cannabinoid receptor. Proc. Natl. Acad. Sci. USA 1999, 96, 14228-33. Harvey, D.J., ed. Satellite Symposium on Cannabis (3rd: 1984: Oxford, England) Marihuana '84: Proceedings of the Oxford Symposium on Cannabis. Washington, DC: IRL Press, 1985. Herkenham, M. Cannabinoid receptor localization in brain: Relationship to motor and reward systems. In: Kalivas, P.W., and Samson, H.H., eds. The neurobiology of drug and alcohol addiction. Ann N Y Acad Sci 1992, 654, 19-32. Herkenham, M., Lynn, A.B., Little, M.D., Johnson, M.R., Melvin, L.S., de Costa, B.R., Rice, K.C. Cannabinoid receptor localization in Brain. Proc. Natl. Acad. Sci. USA. 1990, 87, 1932-1936. Herning, R.I.; Hooker, W.D.; and Jones, R.T. Tetrahydrocannabinol content and differences in marijuana smoking behavior. Psychopharmacology 1986, 90(2):160-162. Hively, R.L., Mosher, W.A., Hoffman, F.W. Isolation of trans-)9- tetrahydrocannabinol from marihuana. J. Am. Chem. Soc. 1966, 88, 1832-1833. Hollister, L.E. Health aspects of cannabis. Pharmacological Rev. 1986, 38, 1-20. Hollister, L.E. Cannabis. (Literature review). Acta Psychiatr Scand (Suppl) 1988, 78, 108-118. Huestis, M.A., Sampson, A.H., Holicky, B.J., Henningfield, J.E., Cone, E.J. Characterization of the absorption phase of marijuana smoking. Clin. Pharmacol. Ther. 1992a, 52, 31-41. Huestis, M.A.; Henningfield, J.E.; and Cone, E.J. Blood Cannabinoids. 1. Absorption of THC and formation of 11- OH-THC and THC COOH during and after smoking marijuana. J Anal Toxicol 1992b, 16(5), 276-282. Johansson, E.; Halldin, M.M.; Agurell, S.; Hollister, L.E.; and Gillespie, H.K. Terminal elimination plasma half-life of delta 1- tetrahydrocannabinol (delta 1-THC) in heavy users of marijuana. Eur J Clin Pharmacol 1989, 37(3), 273-277. Jones, R.T.; Benowitz, N.L.; and Herning, R.I. Clinical relevance of cannabis tolerance and dependence. J Clin Pharmacol 1981, 21,143S- 152S. Koob, G.F. Neural mechanisms of drug reinforcement. Ann. N Y Acad Sci 1992, 654, 171-191. Lane JD, Phillips-Bute BG. Caffeine deprivation affects vigilance performance and mood. Physiol Behav 1998 65, 171-5. Lemberger L., Rubin A. The physiologic disposition of marihuana in man, Life Sci. 1975,17, 1637-42. Lemberger L., Silberstein, S.D., Axelrod, J., Kopin, I.J. Marihuana: studies on the disposition and metabolism of delta-9- tetrahydrocannabinol in man. Science 1970, 170, 1320-1322. Lemberger L., Weiss, J.L., Watanabe, A.M., Galanter, I.M., Wyatt, R.J., Cardon, P. V. Delta-9-tetrahydrocannabinol: temporal correlation of the psychological effects and blood levels after various routes of administration. New Eng. J. Med. 1972a, 286(13), 685-688. Lemberger, L., Crabtree, R.E., Rowe, H.M. 11-Hydroxy-)<SUP>9</SUP>- tetrahydrocannabinol: pharmacology, disposition and metabolism of a major metabolite of marihuana in man. Science 1972b, 177, 62-63. Martin, B.R.; Mechoulam, R., Razdan, R.K. Discovery and characterization of endogenous cannabinoids. Life Sci. 1999, 65, 573-595. Matsuda, L.A., Lolait, S.J., Brownstein, M.J., Young, A.C., Bonner, T.I. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 1990, 346, 561-564. Mechoulam, R. Cannabinoid chemistry. In Mechoulam, R. (ED.) Marijuana, pp.2-88 (New York, NY, Academic Press, Inc.), 1973. Monitoring the Future. National Results on Adolescent Drug Use. Overview of 1999 Key findings, 1999. Department of Health and Human services. National Institute on Drug Abuse. Rockville, MD. (http:// monitoringthefuture.org) National Institutes of Health (NIH). Workshop on the medical Utility of Marijuana, February 19-20, 1997. (www.nih.gov/news/medmarijuana/ MedicalMarijuana.htm) NHSDA. Summary of Findings from the 1999 National Household Survey on Drug Abuse. Office of Applied Studies. Department of Health and Human services. Substance Abuse and Mental Health Services Administration. National Clearinghouse for Alcohol and Drug information. Rockville, MD. Office of National Drug Control Policy. The National Drug Control Strategy: 2000 Annual Report. Superintendent of Documents, Mail Stop: SSOP, Washington, DC. Oviedo, A., Glowa, J., Herkenham, M. Chronic cannabinoid administration alters cannabinoid receptor binding in rat brain: a quantitative autoradiographic study. Brain Res. 1993, 616, 293-302. Rinaldi-Carmona, M., Barth F., Heaulme, M., Shire, D., Calandra, B., Congy, C., Martinez, S., Maruani, J., Neliat, G., Caput, D., et al. SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Letters 1994, 350, 240-244. Rinaldi-Carmona M, Barth F, Millan J, Derocq JM, Casellas P, Congy C, Oustric D, Sarran M, Bouaboula M, Calandra B, Portier M, Shire D, Breliere JC, Le Fur GL, SR 144528, the first potent and selective antagonist of the CB<INF>2</INF> cannabinoid receptor. J Pharmacol Exp Ther. 1998 , 284(2), 644-50. Rodriguez de Fonseca F, Gorriti, M.A., Fernandez-Ruiz, J.J., Palomo, T., Ramos, J.A. Downregulation of rat brain cannabinoid binding sites after chronic delta 9-tetrahydrocannabinoil treatment. Phamacol. Biochem. Behav. 1994, 47 (1), 33-40. Ross, S.A. and ElSohlyy, M.A. Constituents of Cannabis Sativa L. XXVIII. A review of the natural constituents:1980-1994. Zagazig J. Pharm. Sci. 1995, 4 (2), 1-10. Sanudo-Pena M.C., Tsou, K., Delay, E.R., Hohman, A.G., Force, M., Walker, J.M. Endogenous cannabinoids as an aversive or counter- rewarding system in the rat. Neurosci. Lett., 223, 125-128, 1997. Treatment Episode Data Set (TEDS): 1993-1998. National Admissions to Substance Abuse Treatment Services. Department of Health and Human services. Substance Abuse and Mental Health Services Administration. National Clearinghouse for Alcohol and Drug information. Rockville, MD. Wesson, D.R.; Washburn, P. Current patterns of drug abuse that involve smoking. In Research Findings on Smoking of Abused Substances, Chiang, C.N.; Hawks, R.L. (ED.) 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