{"abstract":"The Food and Drug Administration (FDA) is amending the interim final rule on use of materials derived from cattle in human food and cosmetics published in the Federal Register of July 14, 2004. In the July 14, 2004, interim final rule, FDA designated certain materials from cattle, including the entire small intestine, as \"prohibited cattle materials\" and banned the use of such materials in human food, including dietary supplements, and in cosmetics. FDA is taking this action in response to comments received on the interim final rule. Information was provided in comments that persuaded the agency that the distal ileum, one of three portions of the small intestine, could be consistently and effectively removed from the small intestine, such that the remainder of the small intestine, formerly a prohibited cattle material, could be used for human food or cosmetics. We (FDA) are also clarifying that milk and milk products, hide and hide-derived products, and tallow derivatives are not prohibited cattle materials. Comments also led the agency to reconsider the method cited in the interim final rule for determining insoluble impurities in tallow and to cite instead a method that is less costly to use and requires less specialized equipment. FDA issued the interim final rule to minimize human exposure to materials that scientific studies have demonstrated are highly likely to contain the bovine spongiform encephalopathy (BSE) agent in cattle infected with the disease. FDA believes that the amended provisions of the interim final rule provide the same level of protection from human exposure to the agent that causes BSE as the original provisions.","action":"Interim final rule and request for comments.","agencies":[{"raw_name":"DEPARTMENT OF HEALTH AND HUMAN SERVICES","name":"Health and Human Services Department","id":221,"url":"https://www.federalregister.gov/agencies/health-and-human-services-department","json_url":"https://www.federalregister.gov/api/v1/agencies/221","parent_id":null,"slug":"health-and-human-services-department"},{"raw_name":"Food and Drug Administration","name":"Food and Drug Administration","id":199,"url":"https://www.federalregister.gov/agencies/food-and-drug-administration","json_url":"https://www.federalregister.gov/api/v1/agencies/199","parent_id":221,"slug":"food-and-drug-administration"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2005/09/07/05-17693.html","cfr_references":[{"chapter":null,"citation_url":null,"part":189,"title":21},{"chapter":null,"citation_url":null,"part":700,"title":21}],"citation":"70 FR 53063","comment_url":null,"comments_close_on":"2005-10-07","correction_of":null,"corrections":[],"dates":"The amendments to the interim final rule are effective October 7, 2005. Submit written or electronic comments on the amendments to the interim final rule by November 7, 2005. The Director of the Office of the Federal Register approves the incorporation by reference in accordance with 5 U.S.C. 552(a) and 1 CFR part 51 of certain publications in 21 CFR 189.5 and 700.27 as of October 7, 2005.","disposition_notes":null,"docket_ids":["Docket No. 2004N-0081"],"dockets":[],"document_number":"05-17693","effective_on":"2005-10-07","end_page":53069,"executive_order_notes":null,"executive_order_number":null,"full_text_xml_url":"https://www.federalregister.gov/documents/full_text/xml/2005/09/07/05-17693.xml","html_url":"https://www.federalregister.gov/documents/2005/09/07/05-17693/use-of-materials-derived-from-cattle-in-human-food-and-cosmetics","images":{},"images_metadata":{},"json_url":"https://www.federalregister.gov/api/v1/documents/05-17693?publication_date=2005-09-07","mods_url":"https://www.govinfo.gov/metadata/granule/FR-2005-09-07/05-17693/mods.xml","not_received_for_publication":null,"page_length":7,"page_views":{"count":564,"last_updated":"2026-08-25 12:15:05 -0400"},"pdf_url":"https://www.govinfo.gov/content/pkg/FR-2005-09-07/pdf/05-17693.pdf","presidential_document_number":null,"proclamation_number":null,"public_inspection_pdf_url":null,"publication_date":"2005-09-07","raw_text_url":"https://www.federalregister.gov/documents/full_text/text/2005/09/07/05-17693.txt","regulation_id_number_info":{"0910-AF47":{"issue":"201510","html_url":"https://www.federalregister.gov/regulations/0910-AF47/use-of-materials-derived-from-cattle-in-human-food-and-cosmetics","title":"Use of Materials Derived From Cattle in Human Food and Cosmetics","xml_url":"http://www.reginfo.gov/public/do/eAgendaViewRule?pubId=201510&RIN=0910-AF47&operation=OPERATION_EXPORT_XML","priority_category":"Other Significant"}},"regulation_id_numbers":["0910-AF47"],"regulations_dot_gov_info":{"checked_regulationsdotgov_at":"2011-11-12T17:06:19Z"},"regulations_dot_gov_url":null,"significant":true,"signing_date":null,"start_page":53063,"subtype":null,"title":"Use of Materials Derived From Cattle in Human Food and Cosmetics","toc_doc":"Cattle materials; prohibited use","toc_subject":"Food and cosmetics:","topics":["Cosmetics","Food additives","Food packaging","Incorporation by reference","Packaging and containers"],"type":"Rule","volume":70}