{"abstract":"The Food and Drug Administration (FDA) is reopening the comment period for the proposed rule published in the Federal Register of April 17, 1997 (the 1997 proposed rule). The 1997 proposed rule would replace the voluntary petition process to affirm the generally recognized as safe (GRAS) status of a substance intended for use in food for humans or animals with a voluntary notification procedure. FDA is reopening the comment period to update comments. The proposed rule would also clarify the criteria for exempting the use of a substance as GRAS.","action":"Proposed rule; reopening of the comment period.","agencies":[{"raw_name":"DEPARTMENT OF HEALTH AND HUMAN SERVICES","name":"Health and Human Services Department","id":221,"url":"https://www.federalregister.gov/agencies/health-and-human-services-department","json_url":"https://www.federalregister.gov/api/v1/agencies/221","parent_id":null,"slug":"health-and-human-services-department"},{"raw_name":"Food and Drug Administration","name":"Food and Drug Administration","id":199,"url":"https://www.federalregister.gov/agencies/food-and-drug-administration","json_url":"https://www.federalregister.gov/api/v1/agencies/199","parent_id":221,"slug":"food-and-drug-administration"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2010/12/28/2010-32344.html","cfr_references":[{"chapter":null,"citation_url":null,"part":170,"title":21},{"chapter":null,"citation_url":null,"part":184,"title":21},{"chapter":null,"citation_url":null,"part":186,"title":21},{"chapter":null,"citation_url":null,"part":570,"title":21}],"citation":"75 FR 81536","comment_url":null,"comments_close_on":"1997-04-17","correction_of":null,"corrections":[],"dates":"The comment period for the proposed rule published April 17, 1997 (62 FR 18938), is reopened. Submit either electronic or written comments on the proposed rule by March 28, 2011. Submit comments on information collection issues under the Paperwork Reduction Act of 1995 by February 28, 2011, (see the \"Paperwork Reduction Act of 1995\" section of this document).","disposition_notes":null,"docket_ids":["Docket No. FDA-1997-N-0020","Formerly Docket No. 1997N-0103"],"dockets":[],"document_number":"2010-32344","effective_on":null,"end_page":81543,"executive_order_notes":null,"executive_order_number":null,"explanation":null,"full_text_xml_url":"https://www.federalregister.gov/documents/full_text/xml/2010/12/28/2010-32344.xml","html_url":"https://www.federalregister.gov/documents/2010/12/28/2010-32344/substances-generally-recognized-as-safe-reopening-of-the-comment-period","images":{},"images_metadata":{},"json_url":"https://www.federalregister.gov/api/v1/documents/2010-32344?publication_date=2010-12-28","mods_url":"https://www.govinfo.gov/metadata/granule/FR-2010-12-28/2010-32344/mods.xml","not_received_for_publication":null,"page_length":8,"page_views":{"count":802,"last_updated":"2026-04-04 12:15:04 -0400"},"pdf_url":"https://www.govinfo.gov/content/pkg/FR-2010-12-28/pdf/2010-32344.pdf","presidential_document_number":null,"proclamation_number":null,"public_inspection_pdf_url":null,"publication_date":"2010-12-28","raw_text_url":"https://www.federalregister.gov/documents/full_text/text/2010/12/28/2010-32344.txt","regulation_id_number_info":{},"regulation_id_numbers":[],"regulations_dot_gov_info":{"supporting_documents":[{"title":"Reference 56-FDA-CVM-Guidance-GFI221-2015 re Substances Generally Recognized as Safe","document_id":"FDA-1997-N-0020-0177"},{"title":"Reference 51-GRAS-FRIA-August2016 re Substances Generally Recognized as Safe","document_id":"FDA-1997-N-0020-0172"},{"title":"Reference 38-FDA-Form-3667 re Substances Generally Recognized as Safe","document_id":"FDA-1997-N-0020-0160"},{"title":"Reference 37-FDA-CFSAN-Guidance-Electronic-Submissions re Substances Generally Recognized as Safe","document_id":"FDA-1997-N-0020-0159"},{"title":"Reference 33-FDA-CFSAN-Guidance-Enzymes re Substances Generally Recognized as Safe","document_id":"FDA-1997-N-0020-0155"},{"title":"Reference 32-FDA-CFSAN-Guidance-Antimicrobial-Substances re Substances Generally Recognized as Safe","document_id":"FDA-1997-N-0020-0154"},{"title":"Reference 26-Renwick-Food-Chem-Toxicology re Substances Generally Recognized as Safe","document_id":"FDA-1997-N-0020-0149"},{"title":"Reference 17-ILSI-North America-Caffeine-Working-Group-accessed-06-08-2016 re Substances Generally Recognized as Safe","document_id":"FDA-1997-N-0020-0140"},{"title":"Reference 12-FDA-2010-Warning Letter To Phusion Projects re Substances Generally Recognized as Safe","document_id":"FDA-1997-N-0020-0135"},{"title":"Reference 11-FDA-2010-Warning Letter To New Century Brewing re Substances Generally Recognized as Safe","document_id":"FDA-1997-N-0020-0134"}],"comments_url":"https://www.regulations.gov/docketBrowser?rpp=50&so=DESC&sb=postedDate&po=0&dct=PS&D=FDA-1997-N-0020","supporting_documents_count":115,"docket_id":"FDA-1997-N-0020","regulation_id_number":null,"title":"Substances Generally Recognized as Safe (GRAS) - Closed","checked_regulationsdotgov_at":"2011-01-14T08:29:30Z"},"regulations_dot_gov_url":null,"significant":null,"signing_date":null,"start_page":81536,"subtype":null,"title":"Substances Generally Recognized as Safe; Reopening of the Comment Period","toc_doc":"Substances Generally Recognized as Safe","toc_subject":null,"topics":[],"type":"Proposed Rule","volume":75}