{"abstract":"The Environmental Protection Agency (EPA) is announcing a 45- day public comment period for the External Review Draft of \"Guidance for Applying Quantitative Data to Develop Data-Derived Extrapolation Factors for Interspecies and Intraspecies Extrapolation.\" EPA is releasing this draft document solely for the purpose of seeking public comment prior to external peer review. The document will undergo independent peer review during an expert peer review meeting, which will be convened, organized, and conducted by an EPA contractor in 2011. The date of the external peer review meeting will be announced in a subsequent Federal Register notice. All comments received by the docket closing date July 25, 2011 will be shared with the external peer review panel for their consideration. Comments received after the close of the comment period may be considered by EPA when it finalizes the document. This document has not been formally disseminated by EPA. This draft guidance does not represent and should not be construed to represent EPA policy, viewpoint, or determination. Members of the public may obtain the draft interim guidance from http:// www.regulations.gov; or http://www.epa.gov/raf/DDEF/index.htm or from Dr. Michael Broder via the contact information below. This draft Guidance for Data Derived Extrapolation Factors document outlines approaches for developing factors for inter- and intra-species extrapolation based on data describing toxicokinetic and/or toxicodynamic properties of particular agent(s). The draft document was developed to provide guidance for EPA staff in evaluating such data and/or information and to provide information to the regulated community and other interested parties about deriving and implementing extrapolation factors derived from data instead of defaults.","action":"Notice of document availability for public comment.","agencies":[{"raw_name":"ENVIRONMENTAL PROTECTION AGENCY","name":"Environmental Protection Agency","id":145,"url":"https://www.federalregister.gov/agencies/environmental-protection-agency","json_url":"https://www.federalregister.gov/api/v1/agencies/145","parent_id":null,"slug":"environmental-protection-agency"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2011/06/09/2011-14294.html","cfr_references":[],"citation":"76 FR 33752","comment_url":null,"comments_close_on":"2011-07-25","correction_of":null,"corrections":[],"dates":"All comments received by the docket closing date July 25, 2011 will be shared with the external peer review panel for their consideration. Comments received beyond that time may be considered by EPA when it finalizes the document.","disposition_notes":null,"docket_ids":["EPA-HQ-ORD-2009-0694","FRL-9316-6"],"dockets":[],"document_number":"2011-14294","effective_on":null,"end_page":33753,"executive_order_notes":null,"executive_order_number":null,"full_text_xml_url":"https://www.federalregister.gov/documents/full_text/xml/2011/06/09/2011-14294.xml","html_url":"https://www.federalregister.gov/documents/2011/06/09/2011-14294/notice-of-availability-of-the-external-review-draft-of-the-guidance-for-applying-quantitative-data","images":{},"images_metadata":{},"json_url":"https://www.federalregister.gov/api/v1/documents/2011-14294?publication_date=2011-06-09","mods_url":"https://www.govinfo.gov/metadata/granule/FR-2011-06-09/2011-14294/mods.xml","not_received_for_publication":null,"page_length":2,"page_views":{"count":74,"last_updated":"2026-10-23 18:15:05 -0400"},"pdf_url":"https://www.govinfo.gov/content/pkg/FR-2011-06-09/pdf/2011-14294.pdf","presidential_document_number":null,"proclamation_number":null,"public_inspection_pdf_url":null,"publication_date":"2011-06-09","raw_text_url":"https://www.federalregister.gov/documents/full_text/text/2011/06/09/2011-14294.txt","regulation_id_number_info":{},"regulation_id_numbers":[],"regulations_dot_gov_info":{"checked_regulationsdotgov_at":"2011-06-29T08:07:21Z"},"regulations_dot_gov_url":null,"significant":null,"signing_date":null,"start_page":33752,"subtype":null,"title":"Notice of Availability of the External Review Draft of the Guidance for Applying Quantitative Data To Develop Data-Derived Extrapolation Factors for Interspecies and Intraspecies Extrapolation","toc_doc":"Draft Guidance for Applying Quantitative Data to Develop Data-Derived Extrapolation Factors, etc.; Availability","toc_subject":null,"topics":[],"type":"Notice","volume":76}