{"abstract":"The Food and Drug Administration (FDA) is amending the animal drug regulations to reflect approval of an original new animal drug application (NADA) filed by Merial Ltd. The NADA provides for the veterinary prescription use of eprinomectin by injection for the treatment and control of internal and external parasites of cattle on pasture with persistent effectiveness. The current tolerance for the marker residue for total residues of eprinomectin in edible tissues of cattle is being lowered. The method of detection for residues of the carcinogenic excipient n-methyl-2- pyrrolidone (NMP) in edible tissues of cattle is also being codified.","action":"Final rule.","agencies":[{"raw_name":"DEPARTMENT OF HEALTH AND HUMAN SERVICES","name":"Health and Human Services Department","id":221,"url":"https://www.federalregister.gov/agencies/health-and-human-services-department","json_url":"https://www.federalregister.gov/api/v1/agencies/221","parent_id":null,"slug":"health-and-human-services-department"},{"raw_name":"Food and Drug Administration","name":"Food and Drug Administration","id":199,"url":"https://www.federalregister.gov/agencies/food-and-drug-administration","json_url":"https://www.federalregister.gov/api/v1/agencies/199","parent_id":221,"slug":"food-and-drug-administration"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2011/11/25/2011-30329.html","cfr_references":[{"chapter":null,"citation_url":null,"part":500,"title":21},{"chapter":null,"citation_url":null,"part":522,"title":21},{"chapter":null,"citation_url":null,"part":556,"title":21}],"citation":"76 FR 72617","comment_url":null,"comments_close_on":null,"correction_of":null,"corrections":[],"dates":"This rule is effective November 25, 2011. The incorporation by reference of a certain method listed in this rule is approved by the Director of the Federal Register as of November 25, 2011.","disposition_notes":null,"docket_ids":["Docket No. FDA-2011-N-0003"],"dockets":[],"document_number":"2011-30329","effective_on":"2011-11-25","end_page":72619,"executive_order_notes":null,"executive_order_number":null,"explanation":null,"full_text_xml_url":"https://www.federalregister.gov/documents/full_text/xml/2011/11/25/2011-30329.xml","html_url":"https://www.federalregister.gov/documents/2011/11/25/2011-30329/animal-drugs-feeds-and-related-products-eprinomectin-n-methyl-2-pyrrolidone","images":{},"images_metadata":{},"json_url":"https://www.federalregister.gov/api/v1/documents/2011-30329?publication_date=2011-11-25","mods_url":"https://www.govinfo.gov/metadata/granule/FR-2011-11-25/2011-30329/mods.xml","not_received_for_publication":null,"page_length":3,"page_views":{"count":583,"last_updated":"2026-04-04 18:15:03 -0400"},"pdf_url":"https://www.govinfo.gov/content/pkg/FR-2011-11-25/pdf/2011-30329.pdf","presidential_document_number":null,"proclamation_number":null,"public_inspection_pdf_url":"https://public-inspection.federalregister.gov/2011-30329.pdf?1322056527","publication_date":"2011-11-25","raw_text_url":"https://www.federalregister.gov/documents/full_text/text/2011/11/25/2011-30329.txt","regulation_id_number_info":{},"regulation_id_numbers":[],"regulations_dot_gov_info":{"supporting_documents":[{"title":"Freedom of Information Summary NADA 141-324 Phenylpropanolamine","document_id":"FDA-2011-N-0003-0081"},{"title":"Freedom of Information Summary NADA 141-331 Pergolide","document_id":"FDA-2011-N-0003-0080"},{"title":"Freedom of Information Summary NADA 141-333 - Milbemycin Oxime, Lufenuron, and Praziquantel","document_id":"FDA-2011-N-0003-0072"},{"title":"Freedom of Information Summary NADA 095-735 - Monensin","document_id":"FDA-2011-N-0003-0069"},{"title":"Freedom of Information Summary NADA 141-207 - Danofloxacin","document_id":"FDA-2011-N-0003-0067"},{"title":"Freedom of Information Summary NADA 141-322 - Gonadotropin Releasing Factor Analog-Diphtheria Toxoid Conjugate","document_id":"FDA-2011-N-0003-0065"},{"title":"Freedom of Information Summary ANDA 200-494 - Gentamicin Sulfate","document_id":"FDA-2011-N-0003-0063"},{"title":"reedom of Information Summary NADA 141-203 Deracoxib","document_id":"FDA-2011-N-0003-0061"},{"title":"Gentamicin Topical Spray (gentamicin sulfate, betamethasone valerate- ANADA 200-416; Freedom of Information Summary","document_id":"FDA-2011-N-0003-0059"},{"title":"Freedom of Information Summary ANDA 200-318 Bimectin Pour-On (Ivermectin)","document_id":"FDA-2011-N-0003-0057"}],"comments_url":"https://www.regulations.gov/docketBrowser?rpp=50&so=DESC&sb=postedDate&po=0&dct=PS&D=FDA-2011-N-0003","supporting_documents_count":32,"docket_id":"FDA-2011-N-0003","regulation_id_number":null,"title":"NADA/ANADA Notices","checked_regulationsdotgov_at":"2011-12-15T08:14:37Z"},"regulations_dot_gov_url":null,"significant":null,"signing_date":null,"start_page":72617,"subtype":null,"title":"Animal Drugs, Feeds, and Related Products; Eprinomectin; N-Methyl-2-Pyrrolidone","toc_doc":"Animal Drugs, Feeds, and Related Products; Eprinomectin; NMethyl2Pyrrolidone","toc_subject":null,"topics":["Animal drugs","Animal feeds","Cancer","Foods","Incorporation by reference","Labeling","Packaging and containers","Polychlorinated biphenyls (PCB's)"],"type":"Rule","volume":76}