{"abstract":"The NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), in collaboration with the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), is planning to convene an independent scientific peer review panel (Panel) to assess the validation status of an up-and-down procedure (UDP) for acute dermal systemic toxicity testing. NICEATM requests nominations of scientific experts who can be considered for the Panel and submission of data for substances tested in in vivo acute dermal and oral systemic toxicity tests.","action":"Request for Data; Request for Nominations of Scientific Experts.","agencies":[{"raw_name":"DEPARTMENT OF HEALTH AND HUMAN SERVICES","name":"Health and Human Services Department","id":221,"url":"https://www.federalregister.gov/agencies/health-and-human-services-department","json_url":"https://www.federalregister.gov/api/v1/agencies/221","parent_id":null,"slug":"health-and-human-services-department"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2012/07/23/2012-17787.html","cfr_references":[],"citation":"77 FR 43089","comment_url":null,"comments_close_on":"2012-09-06","correction_of":null,"corrections":[],"dates":"Nominations and test method data for the acute dermal and oral tests should be submitted by September 6, 2012. Data submitted after this date will be considered in the evaluation where feasible.","disposition_notes":null,"docket_ids":[],"dockets":[],"document_number":"2012-17787","effective_on":null,"end_page":43090,"executive_order_notes":null,"executive_order_number":null,"explanation":null,"full_text_xml_url":"https://www.federalregister.gov/documents/full_text/xml/2012/07/23/2012-17787.xml","html_url":"https://www.federalregister.gov/documents/2012/07/23/2012-17787/evaluation-of-an-up-and-down-procedure-for-acute-dermal-systemic-toxicity-testing-request-for","images":{},"images_metadata":{},"json_url":"https://www.federalregister.gov/api/v1/documents/2012-17787?publication_date=2012-07-23","mods_url":"https://www.govinfo.gov/metadata/granule/FR-2012-07-23/2012-17787/mods.xml","not_received_for_publication":null,"page_length":2,"page_views":{"count":62,"last_updated":"2026-04-04 12:15:04 -0400"},"pdf_url":"https://www.govinfo.gov/content/pkg/FR-2012-07-23/pdf/2012-17787.pdf","presidential_document_number":null,"proclamation_number":null,"public_inspection_pdf_url":"https://public-inspection.federalregister.gov/2012-17787.pdf?1342788757","publication_date":"2012-07-23","raw_text_url":"https://www.federalregister.gov/documents/full_text/text/2012/07/23/2012-17787.txt","regulation_id_number_info":{},"regulation_id_numbers":[],"regulations_dot_gov_info":{"supporting_documents":[],"comments_url":"https://www.regulations.gov/docketBrowser?rpp=50&so=DESC&sb=postedDate&po=0&dct=PS&D=NIH_FRDOC_0001","supporting_documents_count":0,"docket_id":"NIH_FRDOC_0001","regulation_id_number":null,"title":"Recently Posted NIH Rules and Notices.","checked_regulationsdotgov_at":"2012-09-08T05:00:57Z"},"regulations_dot_gov_url":null,"significant":null,"signing_date":null,"start_page":43089,"subtype":null,"title":"Evaluation of an Up-and-Down Procedure for Acute Dermal Systemic Toxicity Testing: Request for Nominations for an Independent Expert Panel and Submission of Relevant Data","toc_doc":"Evaluation of Up-and-Down Procedure for Acute Dermal Systemic Toxicity Testing","toc_subject":"Requests for Nominations for Independent Expert Panels and Submissions of Relevant Data:","topics":[],"type":"Notice","volume":77}