{"abstract":"The Food and Drug Administration (FDA or we) is announcing a public meeting to solicit comments on certain topics related to our guidance titled \"Toxicological Principles for the Safety Assessment of Food Ingredients,\" known less formally as the \"Redbook.\" The purpose of our public meeting is to invite public input into possibly expanding the scope of the Redbook to include chemical safety assessments for all products over which FDA's Center for Food Safety and Applied Nutrition (CFSAN) has statutory authority including regulatory contexts such as food additives, food contact substances, dietary supplement ingredients, food contaminants, and cosmetics. The Redbook would describe toxicological principles which apply across regulatory categories while still providing specific guidance for applying these principles within each particular context. The safety of foods containing microbial contaminants will continue to remain outside of the scope of the Redbook.","action":"Notification of public meeting; request for comments.","agencies":[{"raw_name":"DEPARTMENT OF HEALTH AND HUMAN SERVICES","name":"Health and Human Services Department","id":221,"url":"https://www.federalregister.gov/agencies/health-and-human-services-department","json_url":"https://www.federalregister.gov/api/v1/agencies/221","parent_id":null,"slug":"health-and-human-services-department"},{"raw_name":"Food and Drug Administration","name":"Food and Drug Administration","id":199,"url":"https://www.federalregister.gov/agencies/food-and-drug-administration","json_url":"https://www.federalregister.gov/api/v1/agencies/199","parent_id":221,"slug":"food-and-drug-administration"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2014/10/30/2014-25800.html","cfr_references":[],"citation":"79 FR 64603","comment_url":null,"comments_close_on":null,"correction_of":null,"corrections":[],"dates":"See section III, \"How to Participate in the Public Meeting,\" in the SUPPLEMENTARY INFORMATION section of this document for the date and time of the public meeting, closing dates for advance registration, and information on deadlines for submitting either electronic or written comments to FDA's Division of Dockets Management.","disposition_notes":null,"docket_ids":["Docket No. FDA-2014-N-1497"],"dockets":[],"document_number":"2014-25800","effective_on":null,"end_page":64604,"executive_order_notes":null,"executive_order_number":null,"full_text_xml_url":"https://www.federalregister.gov/documents/full_text/xml/2014/10/30/2014-25800.xml","html_url":"https://www.federalregister.gov/documents/2014/10/30/2014-25800/toxicological-principles-for-the-safety-assessment-of-food-ingredients-public-meeting-on-updates-and","images":{},"images_metadata":{},"json_url":"https://www.federalregister.gov/api/v1/documents/2014-25800?publication_date=2014-10-30","mods_url":"https://www.govinfo.gov/metadata/granule/FR-2014-10-30/2014-25800/mods.xml","not_received_for_publication":null,"page_length":2,"page_views":{"count":2196,"last_updated":"2026-10-23 22:15:05 -0400"},"pdf_url":"https://www.govinfo.gov/content/pkg/FR-2014-10-30/pdf/2014-25800.pdf","presidential_document_number":null,"proclamation_number":null,"public_inspection_pdf_url":"https://public-inspection.federalregister.gov/2014-25800.pdf?1414587593","publication_date":"2014-10-30","raw_text_url":"https://www.federalregister.gov/documents/full_text/text/2014/10/30/2014-25800.txt","regulation_id_number_info":{},"regulation_id_numbers":[],"regulations_dot_gov_info":{"supporting_documents":[],"comments_url":"https://www.regulations.gov/docketBrowser?rpp=50&so=DESC&sb=postedDate&po=0&dct=PS&D=FDA-2014-N-1497","supporting_documents_count":0,"docket_id":"FDA-2014-N-1497","regulation_id_number":null,"title":"Toxicological Principles for the Safety Assessment of Food Ingredients; Public Meeting on Updates and Safety and Risk Assessment Considerations","checked_regulationsdotgov_at":"2015-02-10T05:00:32Z"},"regulations_dot_gov_url":null,"significant":null,"signing_date":null,"start_page":64603,"subtype":null,"title":"Toxicological Principles for the Safety Assessment of Food Ingredients; Public Meeting on Updates and Safety and Risk Assessment Considerations; Request for Comments","toc_doc":"Toxicological Principles for the Safety Assessment of Food Ingredients; Updates and Safety and Risk Assessment Considerations","toc_subject":"Meetings:","topics":[],"type":"Notice","volume":79}