{"abstract":"The Environmental Protection Agency (EPA) is announcing a 45- day public comment period associated with the release of the Systematic Review Protocol for the Hexavalent Chromium (Cr(VI))] IRIS Assessment. This document communicates the rationale for conducting the assessment of Cr(VI), describes screening criteria to identify relevant literature, outlines the approach for evaluating study quality, and describes the process of evidence synthesis/integration and dose- response methods. The protocol includes the list of studies currently considered in the assessment. EPA is releasing this protocol for public comment at least 30 days in advance of a public science webinar planned on April 24, 2019.","action":"Notice; request for public comment.","agencies":[{"raw_name":"ENVIRONMENTAL PROTECTION AGENCY","name":"Environmental Protection Agency","id":145,"url":"https://www.federalregister.gov/agencies/environmental-protection-agency","json_url":"https://www.federalregister.gov/api/v1/agencies/145","parent_id":null,"slug":"environmental-protection-agency"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2019/03/15/2019-04904.html","cfr_references":[],"citation":"84 FR 9516","comment_url":null,"comments_close_on":"2019-04-29","correction_of":null,"corrections":[],"dates":"The 45-day public comment period begins March 15, 2019 and ends April 29, 2019. Comments must be received on or before April 29, 2019.","disposition_notes":null,"docket_ids":["EPA-HQ-ORD-2014-0313","FRL-9990-88-ORD"],"dockets":[{"supporting_documents":[{"title":"Summary of Public Comments Cr(VI) final January 2023","document_id":"EPA-HQ-ORD-2014-0313-0056"},{"title":"Hexavalent Chromium Supplemental Materials HERO October 2022 508","document_id":"EPA-HQ-ORD-2014-0313-0055"},{"title":"Hexavalent Chromium Tox Review HERO October 2022 ERD 508","document_id":"EPA-HQ-ORD-2014-0313-0054"},{"title":"Hexavalent Chromium SR Protocol HERO October 2022 ERD 508","document_id":"EPA-HQ-ORD-2014-0313-0053"},{"title":"Hexavalent Chromium Draft Charge October 2022 ERD 508","document_id":"EPA-HQ-ORD-2014-0313-0052"},{"title":"Availability of the Draft Integrated Risk Information System (IRIS) Toxicological Review of Hexavalent Chromium","document_id":"EPA-HQ-ORD-2014-0313-0033"},{"title":"Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Preliminary Assessment Materials) [EPA/635/R-18/155]","document_id":"EPA-HQ-ORD-2014-0313-0018"},{"title":"Availability of the Systematic Review Protocol for the Hexavalent Chromium (Cr(VI)) Integrated Risk Information System (IRIS) Assessment","document_id":"EPA-HQ-ORD-2014-0313-0017"},{"title":"Memorandum Opening Docket for Public Access","document_id":"EPA-HQ-ORD-2014-0313-0001"}],"agency_name":null,"documents":[{"comment_count":15,"comment_start_date":"2019-03-15","updated_at":"2023-02-28T18:24:02.226-05:00","comment_url":"https://www.regulations.gov/commenton/EPA-HQ-ORD-2014-0313-0017","allow_late_comments":null,"id":"EPA-HQ-ORD-2014-0313-0017","comment_end_date":"2019-04-30","regulations_dot_gov_open_for_comment":false}],"supporting_documents_count":9,"id":"EPA-HQ-ORD-2014-0313","title":"IRIS Assessment Materials for Hexavalent Chromium"}],"document_number":"2019-04904","effective_on":null,"end_page":9517,"executive_order_notes":null,"executive_order_number":null,"full_text_xml_url":"https://www.federalregister.gov/documents/full_text/xml/2019/03/15/2019-04904.xml","html_url":"https://www.federalregister.gov/documents/2019/03/15/2019-04904/availability-of-the-systematic-review-protocol-for-the-hexavalent-chromium-crvi-integrated-risk","images":{},"images_metadata":{},"json_url":"https://www.federalregister.gov/api/v1/documents/2019-04904?publication_date=2019-03-15","mods_url":"https://www.govinfo.gov/metadata/granule/FR-2019-03-15/2019-04904/mods.xml","not_received_for_publication":null,"page_length":2,"page_views":{"count":734,"last_updated":"2026-08-23 22:15:04 -0400"},"pdf_url":"https://www.govinfo.gov/content/pkg/FR-2019-03-15/pdf/2019-04904.pdf","presidential_document_number":null,"proclamation_number":null,"public_inspection_pdf_url":"https://public-inspection.federalregister.gov/2019-04904.pdf?1552567527","publication_date":"2019-03-15","raw_text_url":"https://www.federalregister.gov/documents/full_text/text/2019/03/15/2019-04904.txt","regulation_id_number_info":{},"regulation_id_numbers":[],"regulations_dot_gov_info":{"supporting_documents":[{"title":"Summary of Public Comments Cr(VI) final January 2023","document_id":"EPA-HQ-ORD-2014-0313-0056"},{"title":"Hexavalent Chromium Supplemental Materials HERO October 2022 508","document_id":"EPA-HQ-ORD-2014-0313-0055"},{"title":"Hexavalent Chromium Tox Review HERO October 2022 ERD 508","document_id":"EPA-HQ-ORD-2014-0313-0054"},{"title":"Hexavalent Chromium SR Protocol HERO October 2022 ERD 508","document_id":"EPA-HQ-ORD-2014-0313-0053"},{"title":"Hexavalent Chromium Draft Charge October 2022 ERD 508","document_id":"EPA-HQ-ORD-2014-0313-0052"},{"title":"Availability of the Draft Integrated Risk Information System (IRIS) Toxicological Review of Hexavalent Chromium","document_id":"EPA-HQ-ORD-2014-0313-0033"},{"title":"Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Preliminary Assessment Materials) [EPA/635/R-18/155]","document_id":"EPA-HQ-ORD-2014-0313-0018"},{"title":"Availability of the Systematic Review Protocol for the Hexavalent Chromium (Cr(VI)) Integrated Risk Information System (IRIS) Assessment","document_id":"EPA-HQ-ORD-2014-0313-0017"},{"title":"Memorandum Opening Docket for Public Access","document_id":"EPA-HQ-ORD-2014-0313-0001"}],"comments_count":15,"agency_id":"EPA","comments_url":"https://www.regulations.gov/docketBrowser?rpp=50&so=DESC&sb=postedDate&po=0&dct=PS&D=EPA-HQ-ORD-2014-0313","supporting_documents_count":9,"docket_id":"EPA-HQ-ORD-2014-0313","document_id":"EPA-HQ-ORD-2014-0313-0017","regulation_id_number":null,"title":"IRIS Assessment Materials for Hexavalent Chromium","checked_regulationsdotgov_at":"2023-02-28T23:24:01Z"},"regulations_dot_gov_url":null,"significant":null,"signing_date":null,"start_page":9516,"subtype":null,"title":"Availability of the Systematic Review Protocol for the Hexavalent Chromium (Cr(VI)) Integrated Risk Information System (IRIS) Assessment","toc_doc":"Systematic Review Protocol for the Hexavalent Chromium Integrated Risk Information System Assessment","toc_subject":null,"topics":[],"type":"Notice","volume":84}