{"abstract":"EPA has granted an experimental use permit (EUP) to Oxitec, Ltd to test efficacy of OX5034 Aedes aegypti mosquitoes expressing tetracycline Trans-Activator Variant (tTAV-OX5034) protein for control of wild Aedes aegypti mosquitoes. An EUP permits use of a pesticide for experimental or research purposes only in accordance with the limitations in the permit.","action":"Notice.","agencies":[{"raw_name":"ENVIRONMENTAL PROTECTION AGENCY","name":"Environmental Protection Agency","id":145,"url":"https://www.federalregister.gov/agencies/environmental-protection-agency","json_url":"https://www.federalregister.gov/api/v1/agencies/145","parent_id":null,"slug":"environmental-protection-agency"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2020/06/09/2020-12372.html","cfr_references":[],"citation":"85 FR 35307","comment_url":null,"comments_close_on":null,"correction_of":null,"corrections":[],"dates":null,"disposition_notes":null,"docket_ids":["EPA-HQ-OPP-2019-0274","FRL-10010-07"],"dockets":[],"document_number":"2020-12372","effective_on":null,"end_page":35307,"executive_order_notes":null,"executive_order_number":null,"explanation":null,"full_text_xml_url":"https://www.federalregister.gov/documents/full_text/xml/2020/06/09/2020-12372.xml","html_url":"https://www.federalregister.gov/documents/2020/06/09/2020-12372/issuance-of-an-experimental-use-permit","images":{},"images_metadata":{},"json_url":"https://www.federalregister.gov/api/v1/documents/2020-12372?publication_date=2020-06-09","mods_url":"https://www.govinfo.gov/metadata/granule/FR-2020-06-09/2020-12372/mods.xml","not_received_for_publication":null,"page_length":1,"page_views":{"count":515,"last_updated":"2026-04-04 18:15:03 -0400"},"pdf_url":"https://www.govinfo.gov/content/pkg/FR-2020-06-09/pdf/2020-12372.pdf","presidential_document_number":null,"proclamation_number":null,"public_inspection_pdf_url":"https://public-inspection.federalregister.gov/2020-12372.pdf?1591620322","publication_date":"2020-06-09","raw_text_url":"https://www.federalregister.gov/documents/full_text/text/2020/06/09/2020-12372.txt","regulation_id_number_info":{},"regulation_id_numbers":[],"regulations_dot_gov_info":{"supporting_documents":[{"title":"Species-Specific Larvicide Effective in Killing Female Aedes Aegypti Mosquito Larvae OX5034 Aedes aegypti","document_id":"EPA-HQ-OPP-2019-0274-0471"},{"title":"Experimental Use Permit Amended for 93167-EUP-2 to Allow Releases of OX5034 Aedes\naegypti in Florida and California","document_id":"EPA-HQ-OPP-2019-0274-0470"},{"title":"Response to Comments - OX5034 EUP Amendment and Extension Request","document_id":"EPA-HQ-OPP-2019-0274-0469"},{"title":"EPA’s Response to Comments Received on the August 31, 2021, Notice for an Experimental\nUse Permit Amendment for OX5034 Aedes aegypti Mosquitoes Expressing Tetracycline Trans Activator Variant (tTAV-OX5034) Protein","document_id":"EPA-HQ-OPP-2019-0274-0468"},{"title":"Section G OX5034 Aedes Aegypti: Proposed Field Trial Protocol for an Experimental Use Permit","document_id":"EPA-HQ-OPP-2019-0274-0467"},{"title":"Review of Section G (dated February 18, 2022) for an Experimental Use Permit (EUP) 93167-EUP-2 to Test OX5034 Aedes aegypti Mosquitoes in California and Extend the Existing EUP in Florida","document_id":"EPA-HQ-OPP-2019-0274-0466"},{"title":"Human Health and Environmental Risk Assessment of OX5034 Aedes aegypti Containing Tetracycline-Repressible Transactivator Protein Variant (tTAV-OX5034, New Active Ingredient), DsRed2-OX5034 Protein (new inert ingredient), and the Genetic Material Necessary (Vector pOX5034) for Production of the Proteins in vivo. Data and Information Provided in Support of an Extension and Amendment to a FIFRA","document_id":"EPA-HQ-OPP-2019-0274-0465"},{"title":"Description of 2021 Expansion Amendment to OX5034 Aedes aegypti Mosquito, including Active and Inert\nIngredients","document_id":"EPA-HQ-OPP-2019-0274-0364"},{"title":"Review of the Zhao et al., 2020 study on “Genetic Breakdown of a Tet-off Conditional Lethality System for Insect Population Control” and its Relevance to the OX5034 Ae. Aegypti Experimental Use Permit; EPA File Symbol 93167-EUP-1","document_id":"EPA-HQ-OPP-2019-0274-0362"},{"title":"Letter regards to Meeting with EPA on November 12, 2020 Regarding the Oxitec Experimental Use Permit Approved on April 30, 2020","document_id":"EPA-HQ-OPP-2019-0274-0361"}],"comments_url":"https://www.regulations.gov/docketBrowser?rpp=50&so=DESC&sb=postedDate&po=0&dct=PS&D=EPA-HQ-OPP-2019-0274","supporting_documents_count":20,"docket_id":"EPA-HQ-OPP-2019-0274","regulation_id_number":null,"title":"New Active ingredient for Oxitec OX5034 Aedes aegypti mosquitoes\n\n\n","checked_regulationsdotgov_at":"2020-06-11T03:30:07Z"},"regulations_dot_gov_url":null,"significant":null,"signing_date":null,"start_page":35307,"subtype":null,"title":"Issuance of an Experimental Use Permit","toc_doc":"Experimental Use Permit","toc_subject":null,"topics":[],"type":"Notice","volume":85}