{"abstract":"The Environmental Protection Agency (EPA) is announcing the availability of the final Toxic Substances Control Act (TSCA) risk evaluation of n-Methylpyrrolidone (NMP). The purpose of conducting risk evaluations under TSCA is to determine whether a chemical substance presents an unreasonable risk of injury to health or the environment under the conditions of use, including an unreasonable risk to a relevant potentially exposed or susceptible subpopulation, without consideration of costs or other nonrisk factors. EPA has determined that specific conditions of use of NMP present an unreasonable risk of injury to health. For those conditions of use for which EPA has found an unreasonable risk, EPA must take regulatory action to address that unreasonable risk through risk management measures enumerated in TSCA. EPA has also determined that specific conditions of use do not present unreasonable risk of injury to health or the environment. For those conditions of use for which EPA has found no unreasonable risk to health or the environment, the Agency's determination is a final Agency action and is issued via order in the risk evaluation.","action":"Notice.","agencies":[{"raw_name":"ENVIRONMENTAL PROTECTION AGENCY","name":"Environmental Protection Agency","id":145,"url":"https://www.federalregister.gov/agencies/environmental-protection-agency","json_url":"https://www.federalregister.gov/api/v1/agencies/145","parent_id":null,"slug":"environmental-protection-agency"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2020/12/30/2020-28872.html","cfr_references":[],"citation":"85 FR 86558","comment_url":null,"comments_close_on":null,"correction_of":null,"corrections":[],"dates":null,"disposition_notes":null,"docket_ids":["EPA-HQ-OPPT-2019-0236","FRL-10017-18"],"dockets":[],"document_number":"2020-28872","effective_on":null,"end_page":86560,"executive_order_notes":null,"executive_order_number":null,"full_text_xml_url":"https://www.federalregister.gov/documents/full_text/xml/2020/12/30/2020-28872.xml","html_url":"https://www.federalregister.gov/documents/2020/12/30/2020-28872/n-methylpyrrolidone-nmp-final-toxic-substances-control-act-tsca-risk-evaluation-notice-of","images":{},"images_metadata":{},"json_url":"https://www.federalregister.gov/api/v1/documents/2020-28872?publication_date=2020-12-30","mods_url":"https://www.govinfo.gov/metadata/granule/FR-2020-12-30/2020-28872/mods.xml","not_received_for_publication":null,"page_length":3,"page_views":{"count":1045,"last_updated":"2026-07-25 18:15:03 -0400"},"pdf_url":"https://www.govinfo.gov/content/pkg/FR-2020-12-30/pdf/2020-28872.pdf","presidential_document_number":null,"proclamation_number":null,"public_inspection_pdf_url":"https://public-inspection.federalregister.gov/2020-28872.pdf?1609249537","publication_date":"2020-12-30","raw_text_url":"https://www.federalregister.gov/documents/full_text/text/2020/12/30/2020-28872.txt","regulation_id_number_info":{},"regulation_id_numbers":[],"regulations_dot_gov_info":{"supporting_documents":[{"title":"AG Transmittal Memo for NMP Final Risk Evaluation","document_id":"EPA-HQ-OPPT-2019-0236-0101"},{"title":"20. NMP Supplemental Information File on PBPK Model Code","document_id":"EPA-HQ-OPPT-2019-0236-0100"},{"title":"19. NMP Supplemental Information File on Consumer Exposure Assessment PBPK Model Inputs and Outputs, and Consumer Risk Calculations","document_id":"EPA-HQ-OPPT-2019-0236-0099"},{"title":"8. NMP SR Supplemental Data Quality Evaluation of Ecological Hazard Studies","document_id":"EPA-HQ-OPPT-2019-0236-0088"},{"title":"7. NMP SR Supplemental File Data Quality Evaluation of Consumer and General Population Exposure Studies","document_id":"EPA-HQ-OPPT-2019-0236-0087"},{"title":"6. NMP SR Supplemental File Data Quality Evaluation of Environmental Release and Occupational Exposure Data Common Sources","document_id":"EPA-HQ-OPPT-2019-0236-0086"},{"title":"NMP 00309073","document_id":"EPA-HQ-OPPT-2019-0236-0078"},{"title":"Transmittal Memorandum NMP 07-13-20 additional studies signed","document_id":"EPA-HQ-OPPT-2019-0236-0075"},{"title":"Data Extraction Tables of Additional NMP Studies","document_id":"EPA-HQ-OPPT-2019-0236-0073"},{"title":"NMP Producers Group 1999 Two Generation Reproduction Toxicity Study with NMP in Sprague Dawley Rats Sanitized","document_id":"EPA-HQ-OPPT-2019-0236-0071"}],"comments_count":0,"agency_id":"EPA","comments_url":"https://www.regulations.gov/docketBrowser?rpp=50&so=DESC&sb=postedDate&po=0&dct=PS&D=EPA-HQ-OPPT-2019-0236","supporting_documents_count":64,"docket_id":"EPA-HQ-OPPT-2019-0236","document_id":"EPA-HQ-OPPT-2019-0236-0080","regulation_id_number":null,"title":"Toxic Substances Control Act (TSCA) Science Advisory Committee on Chemicals Review of Risk Evaluation for N-Methyl-2-pyrrolidone (NMP)","checked_regulationsdotgov_at":"2021-01-01T04:30:09Z"},"regulations_dot_gov_url":null,"significant":null,"signing_date":null,"start_page":86558,"subtype":null,"title":"n-Methylpyrrolidone (NMP); Final Toxic Substances Control Act (TSCA) Risk Evaluation; Notice of Availability","toc_doc":"n-Methylpyrrolidone","toc_subject":"Final Toxic Substances Control Act Risk Evaluation:\n","topics":[],"type":"Notice","volume":85}