{"abstract":"The Drug Enforcement Administration is proposing the control of the chemical methyl alpha-phenylacetoacetate (also known as MAPA; methyl 3-oxo-2-phenylbutanoate; methyl 2-phenylacetoacetate; [alpha]- acetyl-benzeneacetic acid, methyl ester; and CAS Number: 16648-44-5) and its optical isomers as a list I chemical under the Controlled Substances Act (CSA). Methyl alpha-phenylacetoacetate is used in clandestine laboratories to illicitly manufacture the schedule II controlled substances phenylacetone (also known as phenyl-2-propanone or P2P), methamphetamine, and amphetamine and is important to the manufacture of these controlled substances. If finalized, this action would subject handlers of methyl alpha-phenylacetoacetate to the chemical regulatory provisions of the CSA and its implementing regulations. This rulemaking does not establish a threshold for domestic and international transactions of methyl alpha- phenylacetoacetate. As such, all transactions of chemical mixtures containing methyl alpha-phenylacetoacetate would be regulated at any concentration and would be subject to control under the CSA.","action":"Notice of proposed rulemaking.","agencies":[{"raw_name":"DEPARTMENT OF JUSTICE","name":"Justice Department","id":268,"url":"https://www.federalregister.gov/agencies/justice-department","json_url":"https://www.federalregister.gov/api/v1/agencies/268","parent_id":null,"slug":"justice-department"},{"raw_name":"Drug Enforcement Administration","name":"Drug Enforcement Administration","id":116,"url":"https://www.federalregister.gov/agencies/drug-enforcement-administration","json_url":"https://www.federalregister.gov/api/v1/agencies/116","parent_id":268,"slug":"drug-enforcement-administration"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2021/03/30/2021-05346.html","cfr_references":[{"chapter":null,"citation_url":null,"part":"1310","title":21}],"citation":"86 FR 16558","comment_url":null,"comments_close_on":"2021-06-01","correction_of":null,"corrections":[],"dates":"Comments must be submitted electronically or postmarked on or before June 1, 2021. Commenters should be aware that the electronic Federal Docket Management System will not accept any comments after 11:59 p.m. Eastern Time on the last day of the comment period.","disposition_notes":null,"docket_ids":["Docket No. DEA-678"],"dockets":[{"supporting_documents":[],"agency_name":"DEA","documents":[{"comment_count":0,"comment_start_date":"2021-03-30","updated_at":"2023-02-28T22:32:11.745-05:00","comment_url":"https://www.regulations.gov/commenton/DEA-2021-0009-0001","allow_late_comments":null,"id":"DEA-2021-0009-0001","comment_end_date":"2021-06-02","regulations_dot_gov_open_for_comment":false}],"supporting_documents_count":0,"id":"DEA-2021-0009","title":"MAPA - Designation as List I Chemical: Methyl alpha-phenylacetoacetate, a Precursor Chemical Used in the Illicit Manufacture of Phenylacetone, Methamphetamine, and Amphetamine"}],"document_number":"2021-05346","effective_on":null,"end_page":16565,"executive_order_notes":null,"executive_order_number":null,"full_text_xml_url":"https://www.federalregister.gov/documents/full_text/xml/2021/03/30/2021-05346.xml","html_url":"https://www.federalregister.gov/documents/2021/03/30/2021-05346/designation-of-methyl-alpha-phenylacetoacetate-a-precursor-chemical-used-in-the-illicit-manufacture","images":{},"images_metadata":{},"json_url":"https://www.federalregister.gov/api/v1/documents/2021-05346?publication_date=2021-03-30","mods_url":"https://www.govinfo.gov/metadata/granule/FR-2021-03-30/2021-05346/mods.xml","not_received_for_publication":null,"page_length":8,"page_views":{"count":2188,"last_updated":"2026-08-24 18:15:04 -0400"},"pdf_url":"https://www.govinfo.gov/content/pkg/FR-2021-03-30/pdf/2021-05346.pdf","presidential_document_number":null,"proclamation_number":null,"public_inspection_pdf_url":"https://public-inspection.federalregister.gov/2021-05346.pdf?1617021915","publication_date":"2021-03-30","raw_text_url":"https://www.federalregister.gov/documents/full_text/text/2021/03/30/2021-05346.txt","regulation_id_number_info":{},"regulation_id_numbers":[],"regulations_dot_gov_info":{"supporting_documents":[],"comments_count":0,"agency_id":"DEA","comments_url":"https://www.regulations.gov/docketBrowser?rpp=50&so=DESC&sb=postedDate&po=0&dct=PS&D=DEA-2021-0009","supporting_documents_count":0,"docket_id":"DEA-2021-0009","document_id":"DEA-2021-0009-0001","regulation_id_number":null,"title":"MAPA - Designation as List I Chemical: Methyl alpha-phenylacetoacetate, a Precursor Chemical Used in the Illicit Manufacture of Phenylacetone, Methamphetamine, and Amphetamine","checked_regulationsdotgov_at":"2023-03-01T03:32:10Z"},"regulations_dot_gov_url":null,"significant":null,"signing_date":null,"start_page":16558,"subtype":null,"title":"Designation of Methyl alpha-phenylacetoacetate, a Precursor Chemical Used in the Illicit Manufacture of Phenylacetone, Methamphetamine, and Amphetamine, as a List I Chemical","toc_doc":"Methyl alpha-phenylacetoacetate, a Precursor Chemical Used in the Illicit Manufacture of Phenylacetone, Methamphetamine, and Amphetamine","toc_subject":"Designation as List I Chemical:\n","topics":["Administrative practice and procedure","Drug traffic control","Exports","Imports","Reporting and recordkeeping requirements"],"type":"Proposed Rule","volume":86}