{"abstract":"This notice announces the availability of EPA's proposed interim registration review decisions and opens a 60-day public comment period on the proposed interim decisions for the following pesticides: Amitraz, cinnamaldehyde, difenoconazole, farnesol and nerolidol, fenbuconazole, isoxaflutole, mesotrione, metaldehyde, MGK-264, Nosema locustae, oxadiazon, oxyfluorfen, piperonyl butoxide (PBO), pyrethrins, tembotrione, topramezone, Ulocladium oudemansii (U3 Strain).","action":"Notice.","agencies":[{"raw_name":"ENVIRONMENTAL PROTECTION AGENCY","name":"Environmental Protection Agency","id":145,"url":"https://www.federalregister.gov/agencies/environmental-protection-agency","json_url":"https://www.federalregister.gov/api/v1/agencies/145","parent_id":null,"slug":"environmental-protection-agency"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2021/08/03/2021-16516.html","cfr_references":[],"citation":"86 FR 41838","comment_url":null,"comments_close_on":"2021-10-04","correction_of":null,"corrections":[],"dates":"Comments must be received on or before October 4, 2021.","disposition_notes":null,"docket_ids":["EPA-HQ-OPP-2017-0750","FRL-8676-01-OCSPP"],"dockets":[{"supporting_documents":[{"title":"Amitraz Interim Registration Review Decision Case Number 0234","document_id":"EPA-HQ-OPP-2009-1015-0038"},{"title":"Amitraz  Proposed Interim Registration Review Decision Case Number 0234 (6-21-2021) Signed (Final Version)","document_id":"EPA-HQ-OPP-2009-1015-0033"},{"title":"Amitraz (HED) Human Health Revised Draft Human Health Risk Assessment for Reg. Review (5-4-2021) DRA Final D461358","document_id":"EPA-HQ-OPP-2009-1015-0032"},{"title":"Amitraz: Data Evaluation Record for the Study “Torsion Study and Collar Placement Simulations for the Preventic Tick Collar for Dogs (EPA Reg. No. 2382-104)”","document_id":"EPA-HQ-OPP-2009-1015-0031"},{"title":"Amitraz. Revised Acute and Chronic Dietary (Food Only) Exposure and Risk Assessment for the Registration Review Risk Assessment","document_id":"EPA-HQ-OPP-2009-1015-0030"},{"title":"Amitraz: Response to Comments on the Draft Human Health Risk Assessment for Registration Review","document_id":"EPA-HQ-OPP-2009-1015-0029"},{"title":"Amitraz: Response to Public Comment on the Draft Ecological Risk Assessment (7-16-19)","document_id":"EPA-HQ-OPP-2009-1015-0028"},{"title":"Amitraz. Revised Occupational and Residential Exposure Assessment for Registration Review (May 2021)","document_id":"EPA-HQ-OPP-2009-1015-0027"},{"title":"Amitraz Transmittal of Updated Incident Data from the Ecological Fate And Effects Division (6-3-2021)","document_id":"EPA-HQ-OPP-2009-1015-0026"},{"title":"Amitraz: Tier I Update Review of Human Incidents and Epidemiology for Draft Risk Assessment (HED)","document_id":"EPA-HQ-OPP-2009-1015-0015"}],"agency_name":"EPA","documents":[{"comment_count":3,"comment_start_date":"2021-08-03","updated_at":"2023-02-28T17:26:54.558-05:00","comment_url":"https://www.regulations.gov/commenton/EPA-HQ-OPP-2009-1015-0025","allow_late_comments":null,"id":"EPA-HQ-OPP-2009-1015-0025","comment_end_date":"2021-10-05","regulations_dot_gov_open_for_comment":false}],"supporting_documents_count":21,"id":"EPA-HQ-OPP-2009-1015","title":"Amitraz: Registration Review Docket"},{"supporting_documents":[{"title":"D462474 PBO Occ Handler March 2020 Updates","document_id":"EPA-HQ-OPP-2010-0498-0049"},{"title":"D462474 2021-06 USEPA-OPP-HED Residential SOPs Outdoor Fogging-Misting Systems","document_id":"EPA-HQ-OPP-2010-0498-0047"},{"title":"D462474 2021-06 PBO Residential-Sops-Indoor-Environments (Study Rate)","document_id":"EPA-HQ-OPP-2010-0498-0046"},{"title":"D462474 2021-06 PBO Indoor Post-Application Aerosol MRID 49832601","document_id":"EPA-HQ-OPP-2010-0498-0044"},{"title":"Piperonyl Butoxide (PBO) Proposed Interim Registration Review Decision Case Number 2525","document_id":"EPA-HQ-OPP-2010-0498-0043"},{"title":"Pyrethrins (PC Code 069001), Piperonyl Butoxide (PBO) (PC Code 067501), and N-octyl Bicycloheptene Dicarboximide (MGK-264) (PC Code 057001): Non-agricultural Uses, Usage, and Benefits","document_id":"EPA-HQ-OPP-2010-0498-0042"},{"title":"Pyrethrins (PC Code 069001), Piperonyl Butoxide (PBO) (PC Code 067501), and N-octyl Bicycloheptene Dicarboximide (MGK-264) (PC Code 057001): Agricultural and Post-Harvest Uses, Usage, and Benefits","document_id":"EPA-HQ-OPP-2010-0498-0041"},{"title":"Piperonyl Butoxide (PBO). Addendum to the Occupational and Residential Exposure Assessment for Registration Review and Assessment of a Proposed Section 3 Use on Fungi, Edible, Group 21","document_id":"EPA-HQ-OPP-2010-0498-0038"},{"title":"Piperonyl Butoxide (PBO): Preliminary Ecological Risk Assessment for Registration Review","document_id":"EPA-HQ-OPP-2010-0498-0025"},{"title":"Piperonyl Butoxide. Acute and Chronic Dietary Exposure Analyses for New Uses of Piperonyl Butoxide on Edible Fungi Crop Group 21 and the Registration Review of Piperonyl Butoxide.","document_id":"EPA-HQ-OPP-2010-0498-0024"}],"agency_name":"EPA","documents":[{"comment_count":21,"comment_start_date":"2021-08-03","updated_at":"2023-02-28T17:26:56.686-05:00","comment_url":"https://www.regulations.gov/commenton/EPA-HQ-OPP-2010-0498-0035","allow_late_comments":null,"id":"EPA-HQ-OPP-2010-0498-0035","comment_end_date":"2021-11-04","regulations_dot_gov_open_for_comment":false}],"supporting_documents_count":33,"id":"EPA-HQ-OPP-2010-0498","title":"Piperonyl Butoxide Registration Review"},{"supporting_documents":[{"title":"Cinnamaldehyde PC Code 040506 Interim Registration Decision Case Number 6032","document_id":"EPA-HQ-OPP-2010-0918-0011"},{"title":"Cinnamaldehyde PC Code 040506 Proposed Interim Registration Review Decision Case Number 6032","document_id":"EPA-HQ-OPP-2010-0918-0008"},{"title":"Final Work Plan for Cinnamaldehyde (June 30, 2011)","document_id":"EPA-HQ-OPP-2010-0918-0006"},{"title":"Preliminary Assessment for the Registration Review of Cinnamaldehyde (Amended)","document_id":"EPA-HQ-OPP-2010-0918-0005"},{"title":"Cinnamaldehyde Final Work Plan","document_id":"EPA-HQ-OPP-2010-0918-0004"},{"title":"Cinnamaldehyde Preliminary Work Plan and Summary Document","document_id":"EPA-HQ-OPP-2010-0918-0003"},{"title":"Preliminary Assessment for the Registration Review of Cinnmaldehyde","document_id":"EPA-HQ-OPP-2010-0918-0002"}],"agency_name":"EPA","documents":[{"comment_count":1,"comment_start_date":"2021-08-03","updated_at":"2023-02-28T17:26:55.855-05:00","comment_url":"https://www.regulations.gov/commenton/EPA-HQ-OPP-2010-0918-0007","allow_late_comments":null,"id":"EPA-HQ-OPP-2010-0918-0007","comment_end_date":"2021-10-05","regulations_dot_gov_open_for_comment":false}],"supporting_documents_count":7,"id":"EPA-HQ-OPP-2010-0918","title":"Registration Review of Cinnamaldehyde"},{"supporting_documents":[{"title":"Isoxaflutole: Response to Comments on the Ecological Risk Assessment as Presented in the Proposed Interim Decision","document_id":"EPA-HQ-OPP-2010-0979-0044"},{"title":"Isoxaflutole.  Response to Comments on HEDs Draft Human Health Risk Assessment in Support of Registration Review","document_id":"EPA-HQ-OPP-2010-0979-0043"},{"title":"Biological and Economic Analysis Division’s (BEAD) Response to Comment on the Benefits of Isoxaflutole (PC Code 123000)","document_id":"EPA-HQ-OPP-2010-0979-0042"},{"title":"Isoxaflutole Interim Registration Review Decision Case Number 7242","document_id":"EPA-HQ-OPP-2010-0979-0041"},{"title":"P-Hydroxyphenyl-Pyruvate Dioxygenase (HPPD) Inhibitors Cumulative Risk Assessment: Benzobicyclon, Bicyclopyrone, Isoxaflutole, Mesotrione, Pyrasulfotole, Tembotrione, Tolpyralate, and Topramezone","document_id":"EPA-HQ-OPP-2010-0979-0031"},{"title":"Isoxaflutole Proposed Interim Registration Review Decision Case Number 7242","document_id":"EPA-HQ-OPP-2010-0979-0030"},{"title":"Response to Registrant Comments on Addendum to Ecological Risk Assessment for the Isoxaflutole Proposed Section 3 Registration for Use on Soybeans","document_id":"EPA-HQ-OPP-2010-0979-0029"},{"title":"Isoxaflutole Response to Comments on the Draft Ecological Risk Assessment for Registration Review","document_id":"EPA-HQ-OPP-2010-0979-0028"},{"title":"Isoxaflutole.  Completion and Submission of Toxicology Data Evaluation Records","document_id":"EPA-HQ-OPP-2010-0979-0020"},{"title":"Isoxaflutole: Drinking Water Assessment for Registration Review","document_id":"EPA-HQ-OPP-2010-0979-0019"}],"agency_name":"EPA","documents":[{"comment_count":10,"comment_start_date":"2021-08-03","updated_at":"2023-02-28T17:26:57.554-05:00","comment_url":"https://www.regulations.gov/commenton/EPA-HQ-OPP-2010-0979-0026","allow_late_comments":null,"id":"EPA-HQ-OPP-2010-0979-0026","comment_end_date":"2021-10-05","regulations_dot_gov_open_for_comment":false}],"supporting_documents_count":26,"id":"EPA-HQ-OPP-2010-0979","title":"Isoxaflutole Registration Review"},{"supporting_documents":[{"title":"Pyrethrins (PC Code 069001), Piperonyl Butoxide (PBO) (PC Code 067501), and N-octyl bicycloheptene dicarboximide (MGK-264) (PC Code 057001): Agricultural and Post-Harvest Uses, Usage, and Benefits","document_id":"EPA-HQ-OPP-2011-0885-0168"},{"title":"Pyrethrins (PC Code 069001), Piperonyl Butoxide (PBO) (PC Code 067501), and N-octyl Bicycloheptene Dicarboximide (MGK-264) (PC Code 057001): Nonagricultural Uses, Usage, and Benefits","document_id":"EPA-HQ-OPP-2011-0885-0167"},{"title":"Pyrethrins. Response to Comments on HED's Draft Human Health Risk Assessment in Support of Registration Review","document_id":"EPA-HQ-OPP-2011-0885-0166"},{"title":"Pyrethrins Proposed Interim Registration Review Decision Case Number 2580","document_id":"EPA-HQ-OPP-2011-0885-0165"},{"title":"Updated Label Language for the Pyrethroids and Pyrethrins Revised Ecological Risk Mitigation and Response to Comments on the Ecological\nRisk Mitigation Proposal For 23 Chemicals, September 30, 2020","document_id":"EPA-HQ-OPP-2011-0885-0164"},{"title":"Considerations for Bridging Bee-Related Effects and Exposure Data\nfor the Pyrethroids and Pyrethrins","document_id":"EPA-HQ-OPP-2011-0885-0162"},{"title":"Summary of U.S. EPA Teleconference With Pyrethrin Joint Venture and Pyrethrin Stewardship Program","document_id":"EPA-HQ-OPP-2011-0885-0075"},{"title":"Pyrethrins. Response to Reregistration Eligibility Decision (RED) Data Call-In (DCI) Residue Chemistry Data Requirements","document_id":"EPA-HQ-OPP-2011-0885-0062"},{"title":"Pyrethrins. Preliminary Draft Human Health Risk Assessment for Registration Review","document_id":"EPA-HQ-OPP-2011-0885-0061"},{"title":"Pyrethrins. Acute and Chronic Aggregate Dietary (Food and Drinking Water) Exposure and Risk Assessments for the Registration Review Risk Assessment","document_id":"EPA-HQ-OPP-2011-0885-0059"}],"agency_name":"EPA","documents":[{"comment_count":77,"comment_start_date":"2021-08-03","updated_at":"2023-02-28T17:26:54.153-05:00","comment_url":"https://www.regulations.gov/commenton/EPA-HQ-OPP-2011-0885-0163","allow_late_comments":null,"id":"EPA-HQ-OPP-2011-0885-0163","comment_end_date":"2021-11-04","regulations_dot_gov_open_for_comment":false}],"supporting_documents_count":32,"id":"EPA-HQ-OPP-2011-0885","title":"Pyrethrins Registration Review"},{"supporting_documents":[{"title":"MGK-264 Proposed Interim Registration Review Decision Case Number 2430","document_id":"EPA-HQ-OPP-2012-0415-0031"},{"title":"MGK-264: Summary of Domestic Animal Incidents","document_id":"EPA-HQ-OPP-2012-0415-0030"},{"title":"Pyrethrins (PC Code 069001), Piperonyl Butoxide (PBO) (PC Code 067501), and N-octyl bicycloheptene dicarboximide (MGK-264) (PC Code 057001): Agricultural and Post-Harvest Uses, Usage, and Benefits","document_id":"EPA-HQ-OPP-2012-0415-0029"},{"title":"Pyrethrins (PC Code 069001), Piperonyl Butoxide (PBO) (PC Code 067501), and N-octyl Bicycloheptene Dicarboximide (MGK-264) (PC Code 057001): Non-agricultural Uses, Usage, and Benefits","document_id":"EPA-HQ-OPP-2012-0415-0028"},{"title":"MGK-264: Revised Occupational and Residential Exposure and Risk Assessment for Registration Review","document_id":"EPA-HQ-OPP-2012-0415-0027"},{"title":"MGK-264: Revised Human Health Risk Assessment in Support of Registration Review","document_id":"EPA-HQ-OPP-2012-0415-0026"},{"title":"MGK-264. Tier I Update Review of Human Incidents and Epidemiology for Draft Risk Assessment","document_id":"EPA-HQ-OPP-2012-0415-0023"},{"title":"MGK-264. Preliminary Ecological Risk Assessment for Registration Review","document_id":"EPA-HQ-OPP-2012-0415-0022"},{"title":"MGK-264. Occupational and Residential Exposure and Risk Assessment for Registration Review","document_id":"EPA-HQ-OPP-2012-0415-0021"},{"title":"MGK-264. Human Health Risk Assessment in Support of Registration Review","document_id":"EPA-HQ-OPP-2012-0415-0020"}],"agency_name":"EPA","documents":[{"comment_count":12,"comment_start_date":"2021-08-03","updated_at":"2023-02-28T17:26:57.104-05:00","comment_url":"https://www.regulations.gov/commenton/EPA-HQ-OPP-2012-0415-0025","allow_late_comments":null,"id":"EPA-HQ-OPP-2012-0415-0025","comment_end_date":"2021-11-04","regulations_dot_gov_open_for_comment":false}],"supporting_documents_count":23,"id":"EPA-HQ-OPP-2012-0415","title":"Registration Review MGK-264"},{"supporting_documents":[{"title":"Mesotrione Interim Registration Review Decision Case Number 7256","document_id":"EPA-HQ-OPP-2013-0779-0060"},{"title":"Assessment of the Benefits of Mesotrione (PC# 122990) and Impacts of Potential Mitigations","document_id":"EPA-HQ-OPP-2013-0779-0048"},{"title":"Meeting Notes from Mesotrione Registration Review Meeting with Registrants – May 10th and May 12th, 2021","document_id":"EPA-HQ-OPP-2013-0779-0046"},{"title":"Mesotrione Use and Usage Matrix (SUUM)","document_id":"EPA-HQ-OPP-2013-0779-0030"},{"title":"Mesotrione Label Tracking Report","document_id":"EPA-HQ-OPP-2013-0779-0029"},{"title":"Mesotrione Pesticide Label Use Summary - Maximum Use Scenario Report","document_id":"EPA-HQ-OPP-2013-0779-0028"},{"title":"Mesotrione Pesticide Label Use Summary - Line by Line Report","document_id":"EPA-HQ-OPP-2013-0779-0027"},{"title":"Mesotrione (122990) Screening Level Usage Analysis (SLUA)","document_id":"EPA-HQ-OPP-2013-0779-0026"},{"title":"New Pesticide Label Use Summary Vocabulary Guide","document_id":"EPA-HQ-OPP-2013-0779-0025"},{"title":"Mesotrione: Chronic Dietary (Food and Drinking Water) Exposure and Risk Assessment to Support the Draft Human Health Risk Assessment for Registration Review","document_id":"EPA-HQ-OPP-2013-0779-0024"}],"agency_name":"EPA","documents":[{"comment_count":7,"comment_start_date":"2021-08-03","updated_at":"2023-02-28T17:26:54.992-05:00","comment_url":"https://www.regulations.gov/commenton/EPA-HQ-OPP-2013-0779-0047","allow_late_comments":null,"id":"EPA-HQ-OPP-2013-0779-0047","comment_end_date":"2021-10-05","regulations_dot_gov_open_for_comment":false}],"supporting_documents_count":32,"id":"EPA-HQ-OPP-2013-0779","title":"Mesotrione, Registration Review"},{"supporting_documents":[{"title":"Oxyfluorfen: Addendum to the 2019 Draft Human Health Risk Assessment for Registration Review (D445742)","document_id":"EPA-HQ-OPP-2014-0778-0067"},{"title":"Oxyfluorfen: Updated Chronic and Cancer Aggregate Dietary (Food and Drinking Water) Exposure and Risk Assessments to Support Registration Review","document_id":"EPA-HQ-OPP-2014-0778-0066"},{"title":"Oxyfluorfen: Addendum to Drinking Water Exposure Assessment for Registration Review","document_id":"EPA-HQ-OPP-2014-0778-0065"},{"title":"Oxyfluorfen: Response to Comments on the Draft Ecological Risk Assessment and Drinking Water Exposure Assessment for Registration Review","document_id":"EPA-HQ-OPP-2014-0778-0063"},{"title":"Oxyfluorfen Proposed Interim Registration Review Decision Case Number 2490","document_id":"EPA-HQ-OPP-2014-0778-0062"},{"title":"Oxyfluorfen: Review of an Adult Honeybee Acute Contact and Oral Toxicity Study","document_id":"EPA-HQ-OPP-2014-0778-0060"},{"title":"Oxyfluorfen: Review of Studies on Analytical Methods in Soil and Water","document_id":"EPA-HQ-OPP-2014-0778-0059"},{"title":"Oxyfluorfen: Data Evaluation Record for an Aqueous Photolysis Study","document_id":"EPA-HQ-OPP-2014-0778-0057"},{"title":"Anaerobic Aquatic Metabolism of Oxyfluorfen in Two Test Systems MRID 50678601","document_id":"EPA-HQ-OPP-2014-0778-0056"},{"title":"Oxyfluorfen DER Transmittal Memo- Five Ecotoxicological Effects Studies Final","document_id":"EPA-HQ-OPP-2014-0778-0052"}],"agency_name":"EPA","documents":[{"comment_count":19,"comment_start_date":"2021-08-03","updated_at":"2023-02-28T17:26:53.715-05:00","comment_url":"https://www.regulations.gov/commenton/EPA-HQ-OPP-2014-0778-0061","allow_late_comments":null,"id":"EPA-HQ-OPP-2014-0778-0061","comment_end_date":"2021-10-05","regulations_dot_gov_open_for_comment":false}],"supporting_documents_count":54,"id":"EPA-HQ-OPP-2014-0778","title":"Oxyfluorfen Registration Review"},{"supporting_documents":[{"title":"Oxadiazon Interim Registration Review Decision Case Number 2485","document_id":"EPA-HQ-OPP-2014-0782-0151"},{"title":"Pesticide Registration Review: Decisions and Case Closures for Several Pesticides","document_id":"EPA-HQ-OPP-2014-0782-0150"},{"title":"USDA: EPA/OPP/BEAD Follow-up Information & Data Inquiry. 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Chronic Dietary (Food and Drinking Water) Exposure and Risk Assessment to Support the Draft Human Health Risk Assessment for Registration Review","document_id":"EPA-HQ-OPP-2015-0127-0021"}],"agency_name":"EPA","documents":[{"comment_count":5,"comment_start_date":"2021-08-03","updated_at":"2023-02-28T17:26:58.428-05:00","comment_url":"https://www.regulations.gov/commenton/EPA-HQ-OPP-2015-0127-0033","allow_late_comments":null,"id":"EPA-HQ-OPP-2015-0127-0033","comment_end_date":"2021-10-05","regulations_dot_gov_open_for_comment":false}],"supporting_documents_count":26,"id":"EPA-HQ-OPP-2015-0127","title":"Topramezone Registration Review"},{"supporting_documents":[{"title":"Pesticide Registration Review: Decisions and Case Closures for Several Pesticides","document_id":"EPA-HQ-OPP-2015-0401-0066"},{"title":"Difenoconazole Interim Registration Review Decision Case Number 7014","document_id":"EPA-HQ-OPP-2015-0401-0065"},{"title":"Difenoconazole: EFED Response to Comments on the Proposed Interim Registration Review Decision (PID)","document_id":"EPA-HQ-OPP-2015-0401-0064"},{"title":"Difenoconazole. Response to Comments on the Proposed Interim Decision","document_id":"EPA-HQ-OPP-2015-0401-0063"},{"title":"Difenoconazole. Response to Comments on the Human Health Draft Risk Assessment","document_id":"EPA-HQ-OPP-2015-0401-0050"},{"title":"Difenoconazole Proposed Interim Registration Review Decision Case Number 7014","document_id":"EPA-HQ-OPP-2015-0401-0049"},{"title":"Difenoconazole. Response to Comments on the Draft Ecological Risk Assessment for Registration Review","document_id":"EPA-HQ-OPP-2015-0401-0048"},{"title":"Pesticide Registration Review: Proposed Interim Decisions for Several Pesticides","document_id":"EPA-HQ-OPP-2015-0401-0047"},{"title":"Difenoconazole.  Occupational and Residential Exposure Assessment in Support of Difenoconazole Registration Review","document_id":"EPA-HQ-OPP-2015-0401-0022"},{"title":"Difenoconazole.  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