{"abstract":"In accordance with implementing regulations for the Toxic Substances Control Act (TSCA), the Environmental Protection Agency (EPA) is announcing the availability of and soliciting public comment on the draft scope of the risk evaluation to be conducted for octamethylcyclotetra-siloxane (D4). D4 (Cyclotetrasiloxane, 2,2,4,4,6,6,8,8-octamethyl-; Chemical Abstracts Service Registry Number (CASRN) 556-67-2), is a chemical substance for which EPA received a manufacturer request for risk evaluation. The draft scope for this chemical substance includes the conditions of use, hazards, exposures, and the potentially exposed or susceptible subpopulations that EPA plans to consider in conducting the risk evaluation for this chemical substance. EPA is also opening a 45-calendar day comment period on the draft scope to allow for the public to provide additional data or information that could be useful to the Agency in finalizing the scope of the risk evaluation; comments may be submitted to this docket.","action":"Notice.","agencies":[{"raw_name":"ENVIRONMENTAL PROTECTION AGENCY","name":"Environmental Protection Agency","id":145,"url":"https://www.federalregister.gov/agencies/environmental-protection-agency","json_url":"https://www.federalregister.gov/api/v1/agencies/145","parent_id":null,"slug":"environmental-protection-agency"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2021/09/08/2021-19392.html","cfr_references":[],"citation":"86 FR 50347","comment_url":null,"comments_close_on":"2021-10-25","correction_of":null,"corrections":[],"dates":"Comments must be received on or before October 25, 2021.","disposition_notes":null,"docket_ids":["EPA-HQ-OPPT-2018-0443","FRL-8850-01-OCSPP"],"dockets":[{"supporting_documents":[{"title":"22. Draft Risk Calculator for Occupational Exposures for Octamethylcyclotetrasiloxane (D4)","document_id":"EPA-HQ-OPPT-2018-0443-0070"},{"title":"18. Draft Environmental Hazard Assessment for Octamethylcyclotetrasiloxane (D4)","document_id":"EPA-HQ-OPPT-2018-0443-0066"},{"title":"17. Draft Environmental Exposure Assessment for Octamethylcyclotetrasiloxane (D4)","document_id":"EPA-HQ-OPPT-2018-0443-0065"},{"title":"15. Draft Consumer and Indoor Dust Exposure Assessment for Octamethylcyclotetrasiloxane (D4)","document_id":"EPA-HQ-OPPT-2018-0443-0063"},{"title":"13. Draft Physical Chemistry and Fate Assessment for Octamethylcyclotetrasiloxane (D4)","document_id":"EPA-HQ-OPPT-2018-0443-0061"},{"title":"12. Draft Data Extraction Information for Environmental Hazard and Human Health Hazard Animal Toxicology and Epidemiology for Octamethylcyclotetrasiloxane (D4)","document_id":"EPA-HQ-OPPT-2018-0443-0060"},{"title":"10. Draft Data Quality Evaluation Information for Human Health Hazard Animal Toxicology for Octamethylcyclotetrasiloxane (D4)","document_id":"EPA-HQ-OPPT-2018-0443-0058"},{"title":"08. Draft Data Extraction Information for General Population, Consumer, and Environmental Exposure for Octamethylcyclotetrasiloxane (D4)","document_id":"EPA-HQ-OPPT-2018-0443-0056"},{"title":"06. Draft Data Quality Evaluation and Data Extraction Information for Dermal Absorption for Octamethylcyclotetrasiloxane (D4)","document_id":"EPA-HQ-OPPT-2018-0443-0054"},{"title":"05. Draft Data Quality Evaluation and Data Extraction Information for Environmental Release and Occupational Exposure for Octamethylcyclotetrasiloxane (D4)","document_id":"EPA-HQ-OPPT-2018-0443-0053"}],"agency_name":"EPA","documents":[{"comment_count":6,"comment_start_date":"2021-09-08","updated_at":"2023-02-28T17:22:24.960-05:00","comment_url":"https://www.regulations.gov/commenton/EPA-HQ-OPPT-2018-0443-0021","allow_late_comments":null,"id":"EPA-HQ-OPPT-2018-0443-0021","comment_end_date":"2021-10-26","regulations_dot_gov_open_for_comment":false}],"supporting_documents_count":55,"id":"EPA-HQ-OPPT-2018-0443","title":"Octamethylcyclotetra- siloxane (D4); TSCA Review"}],"document_number":"2021-19392","effective_on":null,"end_page":50348,"executive_order_notes":null,"executive_order_number":null,"full_text_xml_url":"https://www.federalregister.gov/documents/full_text/xml/2021/09/08/2021-19392.xml","html_url":"https://www.federalregister.gov/documents/2021/09/08/2021-19392/octamethylcyclotetra-siloxane-d4-draft-scope-of-the-risk-evaluation-to-be-conducted-under-the-toxic","images":{},"images_metadata":{},"json_url":"https://www.federalregister.gov/api/v1/documents/2021-19392?publication_date=2021-09-08","mods_url":"https://www.govinfo.gov/metadata/granule/FR-2021-09-08/2021-19392/mods.xml","not_received_for_publication":null,"page_length":2,"page_views":{"count":678,"last_updated":"2026-10-22 20:15:04 -0400"},"pdf_url":"https://www.govinfo.gov/content/pkg/FR-2021-09-08/pdf/2021-19392.pdf","presidential_document_number":null,"proclamation_number":null,"public_inspection_pdf_url":"https://public-inspection.federalregister.gov/2021-19392.pdf?1631018733","publication_date":"2021-09-08","raw_text_url":"https://www.federalregister.gov/documents/full_text/text/2021/09/08/2021-19392.txt","regulation_id_number_info":{},"regulation_id_numbers":[],"regulations_dot_gov_info":{"supporting_documents":[{"title":"22. Draft Risk Calculator for Occupational Exposures for Octamethylcyclotetrasiloxane (D4)","document_id":"EPA-HQ-OPPT-2018-0443-0070"},{"title":"18. Draft Environmental Hazard Assessment for Octamethylcyclotetrasiloxane (D4)","document_id":"EPA-HQ-OPPT-2018-0443-0066"},{"title":"17. Draft Environmental Exposure Assessment for Octamethylcyclotetrasiloxane (D4)","document_id":"EPA-HQ-OPPT-2018-0443-0065"},{"title":"15. Draft Consumer and Indoor Dust Exposure Assessment for Octamethylcyclotetrasiloxane (D4)","document_id":"EPA-HQ-OPPT-2018-0443-0063"},{"title":"13. Draft Physical Chemistry and Fate Assessment for Octamethylcyclotetrasiloxane (D4)","document_id":"EPA-HQ-OPPT-2018-0443-0061"},{"title":"12. Draft Data Extraction Information for Environmental Hazard and Human Health Hazard Animal Toxicology and Epidemiology for Octamethylcyclotetrasiloxane (D4)","document_id":"EPA-HQ-OPPT-2018-0443-0060"},{"title":"10. Draft Data Quality Evaluation Information for Human Health Hazard Animal Toxicology for Octamethylcyclotetrasiloxane (D4)","document_id":"EPA-HQ-OPPT-2018-0443-0058"},{"title":"08. Draft Data Extraction Information for General Population, Consumer, and Environmental Exposure for Octamethylcyclotetrasiloxane (D4)","document_id":"EPA-HQ-OPPT-2018-0443-0056"},{"title":"06. Draft Data Quality Evaluation and Data Extraction Information for Dermal Absorption for Octamethylcyclotetrasiloxane (D4)","document_id":"EPA-HQ-OPPT-2018-0443-0054"},{"title":"05. Draft Data Quality Evaluation and Data Extraction Information for Environmental Release and Occupational Exposure for Octamethylcyclotetrasiloxane (D4)","document_id":"EPA-HQ-OPPT-2018-0443-0053"}],"comments_count":6,"agency_id":"EPA","comments_url":"https://www.regulations.gov/docketBrowser?rpp=50&so=DESC&sb=postedDate&po=0&dct=PS&D=EPA-HQ-OPPT-2018-0443","supporting_documents_count":55,"docket_id":"EPA-HQ-OPPT-2018-0443","document_id":"EPA-HQ-OPPT-2018-0443-0021","regulation_id_number":null,"title":"Octamethylcyclotetra- siloxane (D4); TSCA Review","checked_regulationsdotgov_at":"2023-02-28T22:22:24Z"},"regulations_dot_gov_url":null,"significant":null,"signing_date":null,"start_page":50347,"subtype":null,"title":"Octamethylcyclotetra-Siloxane (D4); Draft Scope of the Risk Evaluation To Be Conducted Under the Toxic Substances Control Act; Notice of Availability and Request for Comments","toc_doc":"Octamethylcyclotetra-siloxane (D4)","toc_subject":"Draft Scope of the Risk Evaluation to be Conducted under the Toxic Substances Control Act:\n","topics":[],"type":"Notice","volume":86}