{"abstract":"The Assistant Secretary for Preparedness and Response is issuing this revised guidance on a screening framework guidance for providers and users of synthetic oligonucleotides. The Revised Guidance sets forth recommended baseline standards for the gene and genome synthesis industry, as well as best practices for Institutions, Principal Users, End Users, and Third-Party Vendors of oligonucleotides, regarding screening orders and maintaining records consistent with current U.S. regulations. In addition, this Revised Guidance seeks to encourage best practices to address biosecurity concerns associated with the potential misuse of synthetic oligonucleotides to bypass existing regulatory controls and commit unlawful acts.","action":"Notice.","agencies":[{"raw_name":"DEPARTMENT OF HEALTH AND HUMAN SERVICES","name":"Health and Human Services Department","id":221,"url":"https://www.federalregister.gov/agencies/health-and-human-services-department","json_url":"https://www.federalregister.gov/api/v1/agencies/221","parent_id":null,"slug":"health-and-human-services-department"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2022/04/29/2022-09210.html","cfr_references":[],"citation":"87 FR 25495","comment_url":null,"comments_close_on":null,"correction_of":null,"corrections":[],"dates":null,"disposition_notes":null,"docket_ids":[],"dockets":[],"document_number":"2022-09210","effective_on":null,"end_page":25499,"executive_order_notes":null,"executive_order_number":null,"full_text_xml_url":"https://www.federalregister.gov/documents/full_text/xml/2022/04/29/2022-09210.xml","html_url":"https://www.federalregister.gov/documents/2022/04/29/2022-09210/screening-framework-guidance-for-providers-and-users-of-synthetic-oligonucleotides","images":{},"images_metadata":{},"json_url":"https://www.federalregister.gov/api/v1/documents/2022-09210?publication_date=2022-04-29","mods_url":"https://www.govinfo.gov/metadata/granule/FR-2022-04-29/2022-09210/mods.xml","not_received_for_publication":null,"page_length":5,"page_views":{"count":2601,"last_updated":"2026-09-20 12:15:04 -0400"},"pdf_url":"https://www.govinfo.gov/content/pkg/FR-2022-04-29/pdf/2022-09210.pdf","presidential_document_number":null,"proclamation_number":null,"public_inspection_pdf_url":"https://public-inspection.federalregister.gov/2022-09210.pdf?1651149994","publication_date":"2022-04-29","raw_text_url":"https://www.federalregister.gov/documents/full_text/text/2022/04/29/2022-09210.txt","regulation_id_number_info":{},"regulation_id_numbers":[],"regulations_dot_gov_info":{"checked_regulationsdotgov_at":"2022-04-29T08:15:45Z"},"regulations_dot_gov_url":null,"significant":null,"signing_date":null,"start_page":25495,"subtype":null,"title":"Screening Framework Guidance for Providers and Users of Synthetic Oligonucleotides","toc_doc":"Screening Framework for Providers and Users of Synthetic Oligonucleotides","toc_subject":"Guidance:\n","topics":[],"type":"Notice","volume":87}