{"abstract":"The Environmental Protection Agency (EPA) is announcing the availability of a final document titled, \"Integrated Science Assessment for Lead\" (EPA/600/R-23/375). The document was prepared by the Center for Public Health and Environmental Assessment (CPHEA) within EPA's Office of Research and Development (ORD) as part of the review of the primary (health-based) and secondary (welfare-based) lead national ambient air quality standards (NAAQS) and represents an update of the 2013 Integrated Science Assessment (ISA) for Lead (EPA/600/R-10/ 075F). The final lead ISA, in conjunction with additional technical and policy assessments, will provide the scientific foundation for EPA's decisions on the adequacy of the current lead NAAQS and, if appropriate, on potential alternative standards.","action":"Notice of availability.","agencies":[{"raw_name":"ENVIRONMENTAL PROTECTION AGENCY","name":"Environmental Protection Agency","id":145,"url":"https://www.federalregister.gov/agencies/environmental-protection-agency","json_url":"https://www.federalregister.gov/api/v1/agencies/145","parent_id":null,"slug":"environmental-protection-agency"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2024/02/07/2024-02427.html","cfr_references":[],"citation":"89 FR 8425","comment_url":null,"comments_close_on":null,"correction_of":null,"corrections":[],"dates":"The document will be available on or about January 31, 2024.","disposition_notes":null,"docket_ids":["EPA-HQ-ORD-2020-0701","FRL-11654-01-ORD"],"dockets":[{"supporting_documents":[{"title":"2024 Pb ISA Appendix 7 Hematological Effects","document_id":"EPA-HQ-ORD-2020-0701-0051"},{"title":"2024 Pb ISA Appendix 11 Ecological Effects","document_id":"EPA-HQ-ORD-2020-0701-0050"},{"title":"2024 Pb ISA Front Matter Executive Summary and Integrated Synthesis 508c","document_id":"EPA-HQ-ORD-2020-0701-0048"},{"title":"2024 Pb ISA Appendix 3 Nervous System Effects","document_id":"EPA-HQ-ORD-2020-0701-0047"},{"title":"2024 Pb ISA Appendix 12 ISA Process","document_id":"EPA-HQ-ORD-2020-0701-0046"},{"title":"2024 Pb ISA Appendix 4 Cardiovascular Effects","document_id":"EPA-HQ-ORD-2020-0701-0045"},{"title":"2024 Pb ISA Appendix 5 Renal Effects","document_id":"EPA-HQ-ORD-2020-0701-0044"},{"title":"2024 Pb ISA Appendix 2 Exposure Toxicokinetics and Biomarkers","document_id":"EPA-HQ-ORD-2020-0701-0043"},{"title":"2024 Pb ISA Appendix 8 Reproductive and Developmental Effects","document_id":"EPA-HQ-ORD-2020-0701-0042"},{"title":"2024 Pb ISA Appendix 6 Immune Effects","document_id":"EPA-HQ-ORD-2020-0701-0041"}],"agency_name":"EPA","documents":[{"comment_count":0,"comment_start_date":"2024-02-07","updated_at":"2024-02-07T09:05:22.091-05:00","comment_url":"https://www.regulations.gov/commenton/EPA-HQ-ORD-2020-0701-0037","allow_late_comments":null,"id":"EPA-HQ-ORD-2020-0701-0037","comment_end_date":null,"regulations_dot_gov_open_for_comment":false}],"supporting_documents_count":35,"id":"EPA-HQ-ORD-2020-0701","title":"Integrated Science Assessment (ISA) for Lead (Pb)"}],"document_number":"2024-02427","effective_on":null,"end_page":8426,"executive_order_notes":null,"executive_order_number":null,"full_text_xml_url":"https://www.federalregister.gov/documents/full_text/xml/2024/02/07/2024-02427.xml","html_url":"https://www.federalregister.gov/documents/2024/02/07/2024-02427/integrated-science-assessment-for-lead","images":{},"images_metadata":{},"json_url":"https://www.federalregister.gov/api/v1/documents/2024-02427?publication_date=2024-02-07","mods_url":"https://www.govinfo.gov/metadata/granule/FR-2024-02-07/2024-02427/mods.xml","not_received_for_publication":null,"page_length":2,"page_views":{"count":784,"last_updated":"2026-07-26 00:15:03 -0400"},"pdf_url":"https://www.govinfo.gov/content/pkg/FR-2024-02-07/pdf/2024-02427.pdf","presidential_document_number":null,"proclamation_number":null,"public_inspection_pdf_url":"https://public-inspection.federalregister.gov/2024-02427.pdf?1707227117","publication_date":"2024-02-07","raw_text_url":"https://www.federalregister.gov/documents/full_text/text/2024/02/07/2024-02427.txt","regulation_id_number_info":{},"regulation_id_numbers":[],"regulations_dot_gov_info":{"supporting_documents":[{"title":"2024 Pb ISA Appendix 7 Hematological Effects","document_id":"EPA-HQ-ORD-2020-0701-0051"},{"title":"2024 Pb ISA Appendix 11 Ecological Effects","document_id":"EPA-HQ-ORD-2020-0701-0050"},{"title":"2024 Pb ISA Front Matter Executive Summary and Integrated Synthesis 508c","document_id":"EPA-HQ-ORD-2020-0701-0048"},{"title":"2024 Pb ISA Appendix 3 Nervous System Effects","document_id":"EPA-HQ-ORD-2020-0701-0047"},{"title":"2024 Pb ISA Appendix 12 ISA Process","document_id":"EPA-HQ-ORD-2020-0701-0046"},{"title":"2024 Pb ISA Appendix 4 Cardiovascular Effects","document_id":"EPA-HQ-ORD-2020-0701-0045"},{"title":"2024 Pb ISA Appendix 5 Renal Effects","document_id":"EPA-HQ-ORD-2020-0701-0044"},{"title":"2024 Pb ISA Appendix 2 Exposure Toxicokinetics and Biomarkers","document_id":"EPA-HQ-ORD-2020-0701-0043"},{"title":"2024 Pb ISA Appendix 8 Reproductive and Developmental Effects","document_id":"EPA-HQ-ORD-2020-0701-0042"},{"title":"2024 Pb ISA Appendix 6 Immune Effects","document_id":"EPA-HQ-ORD-2020-0701-0041"}],"comments_count":0,"agency_id":"EPA","comments_url":"https://www.regulations.gov/docketBrowser?rpp=50&so=DESC&sb=postedDate&po=0&dct=PS&D=EPA-HQ-ORD-2020-0701","supporting_documents_count":35,"docket_id":"EPA-HQ-ORD-2020-0701","document_id":"EPA-HQ-ORD-2020-0701-0037","regulation_id_number":null,"title":"Integrated Science Assessment (ISA) for Lead (Pb)","checked_regulationsdotgov_at":"2024-02-08T13:00:09Z"},"regulations_dot_gov_url":null,"significant":null,"signing_date":null,"start_page":8425,"subtype":null,"title":"Integrated Science Assessment for Lead","toc_doc":"Integrated Science Assessment for Lead","toc_subject":null,"topics":[],"type":"Notice","volume":89}