{"abstract":"The Environmental Protection Agency (EPA or the \"Agency\") is proposing to address the unreasonable risk of injury to human health presented by n-methylpyrrolidone (NMP) under its conditions of use as documented in EPA's risk evaluation and risk determination for NMP pursuant to the Toxic Substances Control Act (TSCA). NMP is a widely used solvent in a variety of industrial, commercial, and consumer applications including the manufacture and production of electronics such as semiconductors, polymers, petrochemical products, paints and coatings, and paint and coating removers. EPA determined that NMP presents an unreasonable risk of injury to health due to the significant adverse health effects associated with exposure to NMP, including developmental post-implantation fetal loss from short-term exposure and reduced fertility and fecundity from long-term exposure. Additional adverse effects associated with exposure to NMP include liver toxicity, kidney toxicity, immunotoxicity, neurotoxicity, skin irritation, and sensitization. To address the identified unreasonable risk, EPA is proposing to: prohibit the manufacture (including import), processing, and distribution in commerce and use of NMP in several occupational conditions of use; require worker protections through an NMP workplace chemical protection program (WCPP) or prescriptive controls (including concentration limits) for most of the occupational conditions of use; require concentration limits on a consumer product; regulate certain consumer products to prevent commercial use; and establish recordkeeping, labeling, and downstream notification requirements.","action":"Proposed rule.","agencies":[{"raw_name":"ENVIRONMENTAL PROTECTION AGENCY","name":"Environmental Protection Agency","id":145,"url":"https://www.federalregister.gov/agencies/environmental-protection-agency","json_url":"https://www.federalregister.gov/api/v1/agencies/145","parent_id":null,"slug":"environmental-protection-agency"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2024/06/14/2024-12643.html","cfr_references":[{"chapter":null,"citation_url":null,"part":"751","title":40}],"citation":"89 FR 51134","comment_url":null,"comments_close_on":"2024-07-29","correction_of":null,"corrections":[],"dates":"Comments must be received on or before July 29, 2024. Under the Paperwork Reduction Act (PRA), comments on the information collection provisions are best assured of consideration if the Office of Management and Budget (OMB) receives a copy of your comments on or before July 15, 2024.","disposition_notes":null,"docket_ids":["EPA-HQ-OPPT-2020-0744","FRL-8330-02-OCSPP"],"dockets":[{"supporting_documents":[{"title":"Wang, J. H. and A. Hart (2021). \"Global Perspective on Kidney Transplantation: United States.\"","document_id":"EPA-HQ-OPPT-2020-0744-0189"},{"title":"ECHA (2013) Annex XV Restriction Report Proposal for a Restriction. N-Methylpyrrolidone (NMP). Version Number 2.0.","document_id":"EPA-HQ-OPPT-2020-0744-0171"},{"title":"BLS(2023c)  Occupational Employment and Wage Statistics (OEWS). Table 1 National employment and wage data from the Occupational Employment and Wage Statistics survey by occupation, May 2022","document_id":"EPA-HQ-OPPT-2020-0744-0120"},{"title":"Rausch et al. (2012) A cost-effectiveness analysis of surgical versus medical management of early pregnancy loss","document_id":"EPA-HQ-OPPT-2020-0744-0116"},{"title":"Ansell (2008) Chemical Resistance Guide","document_id":"EPA-HQ-OPPT-2020-0744-0096"},{"title":"Argonne National Laboratory (2014) Fact Sheet - Glove Selection","document_id":"EPA-HQ-OPPT-2020-0744-0093"},{"title":"NMP Technical Support Memorandum-Air Pathway","document_id":"EPA-HQ-OPPT-2020-0744-0087"},{"title":"2017 ECEL Memo","document_id":"EPA-HQ-OPPT-2020-0744-0086"},{"title":"EPA. Supplemental Data File of Results of Additional Consumer PBPK Runs","document_id":"EPA-HQ-OPPT-2020-0744-0078"},{"title":"U.S. Consumer Product Safety Commission. What You Should Know About Using Paint Strippers","document_id":"EPA-HQ-OPPT-2020-0744-0075"}],"agency_name":"EPA","documents":[{"comment_count":61,"comment_start_date":"2024-06-14","updated_at":"2025-04-08T21:56:00.718-04:00","comment_url":"https://www.regulations.gov/commenton/EPA-HQ-OPPT-2020-0744-0015","allow_late_comments":false,"id":"EPA-HQ-OPPT-2020-0744-0015","comment_end_date":"2024-07-30","regulations_dot_gov_open_for_comment":false}],"supporting_documents_count":266,"id":"EPA-HQ-OPPT-2020-0744","title":"n-Methylpyrrolidone (NMP); Rulemaking under TSCA Section 6(a)(CASRN 872-50-4)"}],"document_number":"2024-12643","effective_on":null,"end_page":51194,"executive_order_notes":null,"executive_order_number":null,"explanation":null,"full_text_xml_url":"https://www.federalregister.gov/documents/full_text/xml/2024/06/14/2024-12643.xml","html_url":"https://www.federalregister.gov/documents/2024/06/14/2024-12643/n-methylpyrrolidone-nmp-regulation-under-the-toxic-substances-control-act-tsca","images":{},"images_metadata":{},"json_url":"https://www.federalregister.gov/api/v1/documents/2024-12643?publication_date=2024-06-14","mods_url":"https://www.govinfo.gov/metadata/granule/FR-2024-06-14/2024-12643/mods.xml","not_received_for_publication":null,"page_length":61,"page_views":{"count":5907,"last_updated":"2026-05-29 12:15:10 -0400"},"pdf_url":"https://www.govinfo.gov/content/pkg/FR-2024-06-14/pdf/2024-12643.pdf","presidential_document_number":null,"proclamation_number":null,"public_inspection_pdf_url":"https://public-inspection.federalregister.gov/2024-12643.pdf?1718282716","publication_date":"2024-06-14","raw_text_url":"https://www.federalregister.gov/documents/full_text/text/2024/06/14/2024-12643.txt","regulation_id_number_info":{"2070-AK85":{"issue":"202504","html_url":"https://www.federalregister.gov/regulations/2070-AK85/n-methylpyrrolidone-nmp-regulation-under-the-toxic-substances-control-act-tsca-","title":"N-Methylpyrrolidone (NMP); Regulation Under the Toxic Substances Control Act (TSCA)","xml_url":"http://www.reginfo.gov/public/do/eAgendaViewRule?pubId=202504&RIN=2070-AK85&operation=OPERATION_EXPORT_XML","priority_category":"Economically Significant"}},"regulation_id_numbers":["2070-AK85"],"regulations_dot_gov_info":{"supporting_documents":[{"title":"Wang, J. H. and A. Hart (2021). \"Global Perspective on Kidney Transplantation: United States.\"","document_id":"EPA-HQ-OPPT-2020-0744-0189"},{"title":"ECHA (2013) Annex XV Restriction Report Proposal for a Restriction. N-Methylpyrrolidone (NMP). Version Number 2.0.","document_id":"EPA-HQ-OPPT-2020-0744-0171"},{"title":"BLS(2023c)  Occupational Employment and Wage Statistics (OEWS). Table 1 National employment and wage data from the Occupational Employment and Wage Statistics survey by occupation, May 2022","document_id":"EPA-HQ-OPPT-2020-0744-0120"},{"title":"Rausch et al. (2012) A cost-effectiveness analysis of surgical versus medical management of early pregnancy loss","document_id":"EPA-HQ-OPPT-2020-0744-0116"},{"title":"Ansell (2008) Chemical Resistance Guide","document_id":"EPA-HQ-OPPT-2020-0744-0096"},{"title":"Argonne National Laboratory (2014) Fact Sheet - Glove Selection","document_id":"EPA-HQ-OPPT-2020-0744-0093"},{"title":"NMP Technical Support Memorandum-Air Pathway","document_id":"EPA-HQ-OPPT-2020-0744-0087"},{"title":"2017 ECEL Memo","document_id":"EPA-HQ-OPPT-2020-0744-0086"},{"title":"EPA. Supplemental Data File of Results of Additional Consumer PBPK Runs","document_id":"EPA-HQ-OPPT-2020-0744-0078"},{"title":"U.S. Consumer Product Safety Commission. What You Should Know About Using Paint Strippers","document_id":"EPA-HQ-OPPT-2020-0744-0075"}],"regulatory_plan":{"html_url":"https://www.federalregister.gov/regulations/2070-AK85/n-methylpyrrolidone-nmp-regulation-under-the-toxic-substances-control-act-tsca-","title":"N-Methylpyrrolidone (NMP); Regulation Under the Toxic Substances Control Act (TSCA)"},"comments_count":61,"agency_id":"EPA","comments_url":"https://www.regulations.gov/docketBrowser?rpp=50&so=DESC&sb=postedDate&po=0&dct=PS&D=EPA-HQ-OPPT-2020-0744","supporting_documents_count":266,"docket_id":"EPA-HQ-OPPT-2020-0744","document_id":"EPA-HQ-OPPT-2020-0744-0015","regulation_id_number":"2070-AK85","title":"n-Methylpyrrolidone (NMP); Rulemaking under TSCA Section 6(a)(CASRN 872-50-4)","checked_regulationsdotgov_at":"2025-04-10T00:55:04Z"},"regulations_dot_gov_url":null,"significant":true,"signing_date":null,"start_page":51134,"subtype":null,"title":"n-Methylpyrrolidone (NMP); Regulation Under the Toxic Substances Control Act (TSCA)","toc_doc":"n-Methylpyrrolidone","toc_subject":"Regulation under the Toxic Substances Control Act:\n","topics":["Chemicals","Environmental protection","Hazardous substances"],"type":"Proposed Rule","volume":89}