{"abstract":"In the Federal Register of November 19, 2024, EPA issued an advance notice of proposed rulemaking soliciting public comment on and any additional information relevant to the potential risks associated with N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) (CASRN 793-24-8, DTXSID 9025114) and its transformation product, 6PPD-quinone (CASRN 2754428-18-5, DTXSID 301034849). EPA is soliciting that information, along with information about potential alternatives and regulatory options, to help inform the Agency's consideration of potential future regulatory actions under the Toxic Substances Control Act (TSCA). With this document, EPA is extending the comment period by 60 days, from January 21, 2025, to March 24, 2025.","action":"Advance notice of proposed rulemaking, extension of the comment period.","agencies":[{"raw_name":"ENVIRONMENTAL PROTECTION AGENCY","name":"Environmental Protection Agency","id":145,"url":"https://www.federalregister.gov/agencies/environmental-protection-agency","json_url":"https://www.federalregister.gov/api/v1/agencies/145","parent_id":null,"slug":"environmental-protection-agency"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2025/01/17/2025-00731.html","cfr_references":[{"chapter":null,"citation_url":null,"part":751,"title":40}],"citation":"90 FR 5798","comment_url":null,"comments_close_on":"2025-03-24","correction_of":null,"corrections":[],"dates":"The comment period for the document that published on November 19, 2024, at 89 FR 91299) (FRL-11628-01-OCSPP) is extended. Comments must be received on or before March 24, 2025.","disposition_notes":null,"docket_ids":["EPA-HQ-OPPT-2024-0403","FRL-11628-02-OCSPP"],"dockets":[{"supporting_documents":[{"title":"Exposure to 6-PPD Quinone at Environmentally Relevant Concentrations Causes Abnormal Locomotion Behaviors and Neurodegeneration in Caenorhabditis elegans","document_id":"EPA-HQ-OPPT-2024-0403-0089"},{"title":"Transformation Product Formation upon Heterogeneous Ozonation of the Tire Rubber Antioxidant 6PPD (N‑(1,3-dimethylbutyl)‑N′‑phenyl‑p‑phenylenediamine)","document_id":"EPA-HQ-OPPT-2024-0403-0083"},{"title":"E‑Waste Recycling Emits Large Quantities of Emerging Aromatic Amines and Organophosphites: A Poorly Recognized Source for Another Two Classes of Synthetic Antioxidants","document_id":"EPA-HQ-OPPT-2024-0403-0080"},{"title":"Acute Toxicity of 6PPD Quinone to Early Life Stage Juvenile Chinook  (Oncorhynchus tshawytscha) and Coho (Oncorhynchus kisutch) Salmon","document_id":"EPA-HQ-OPPT-2024-0403-0079"},{"title":"Polyethylene Nanoparticles at Environmentally Relevant Concentrations Enhances Neurotoxicity and Accumulation of 6-PPD Quinone in Caenorhabditis elegans","document_id":"EPA-HQ-OPPT-2024-0403-0077"},{"title":"Widespread Occurrence of Two Typical N-substituted p-phenylenediamines and Their Quinones in Humans: Association with Oxidative Stress and Liver Damage","document_id":"EPA-HQ-OPPT-2024-0403-0075"},{"title":"The Tire-Derived Chemical 6PPD-quinone Is Lethally Toxic to the White-Spotted Char Salvelinus leucomaenis pluvius but Not to Two Other Salmonid Species","document_id":"EPA-HQ-OPPT-2024-0403-0074"},{"title":"Laws and Regulations: Listing Motor Vehicle Tires Containing N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) as a Priority Product","document_id":"EPA-HQ-OPPT-2024-0403-0066"},{"title":"Widespread Occurrence and Transport of p‑Phenylenediamines and Their Quinones in Sediments across Urban Rivers, Estuaries, Coasts, and Deep-Sea Regions","document_id":"EPA-HQ-OPPT-2024-0403-0061"},{"title":"Tire Wear Particles in the Aquatic Environment - A Review on Generation, Analysis, Occurrence, Fate and Effects","document_id":"EPA-HQ-OPPT-2024-0403-0060"}],"agency_name":"EPA","documents":[{"comment_count":0,"comment_start_date":"2025-01-17","updated_at":"2025-01-17T15:56:58.954-05:00","comment_url":"https://www.regulations.gov/commenton/EPA-HQ-OPPT-2024-0403-0097","allow_late_comments":false,"id":"EPA-HQ-OPPT-2024-0403-0097","comment_end_date":null,"regulations_dot_gov_open_for_comment":false}],"supporting_documents_count":90,"id":"EPA-HQ-OPPT-2024-0403","title":"N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product, 6PPD-quinone; Regulatory Investigation under the Toxic Substances Control Act (TSCA)"}],"document_number":"2025-00731","effective_on":null,"end_page":5799,"executive_order_notes":null,"executive_order_number":null,"explanation":null,"full_text_xml_url":"https://www.federalregister.gov/documents/full_text/xml/2025/01/17/2025-00731.xml","html_url":"https://www.federalregister.gov/documents/2025/01/17/2025-00731/n-13-dimethylbutyl-n-phenyl-p-phenylenediamine-6ppd-and-its-transformation-product-6ppd-quinone","images":{},"images_metadata":{},"json_url":"https://www.federalregister.gov/api/v1/documents/2025-00731?publication_date=2025-01-17","mods_url":"https://www.govinfo.gov/metadata/granule/FR-2025-01-17/2025-00731/mods.xml","not_received_for_publication":null,"page_length":2,"page_views":{"count":415,"last_updated":"2026-04-04 20:15:04 -0400"},"pdf_url":"https://www.govinfo.gov/content/pkg/FR-2025-01-17/pdf/2025-00731.pdf","presidential_document_number":null,"proclamation_number":null,"public_inspection_pdf_url":"https://public-inspection.federalregister.gov/2025-00731.pdf?1737035116","publication_date":"2025-01-17","raw_text_url":"https://www.federalregister.gov/documents/full_text/text/2025/01/17/2025-00731.txt","regulation_id_number_info":{"2070-AL16":{"issue":"202410","html_url":"https://www.federalregister.gov/regulations/2070-AL16/regulatory-investigation-of-n-1-3-dimethylbutyl-n-phenyl-p-phenylenediamine-6ppd-and-its-transformat","title":"Regulatory Investigation of N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (\"6PPD\") and its Transformation Product, 6PPD-quinone Under the Toxic Substances Control Act (TSCA) ","xml_url":"http://www.reginfo.gov/public/do/eAgendaViewRule?pubId=202410&RIN=2070-AL16&operation=OPERATION_EXPORT_XML","priority_category":"Substantive, Nonsignificant"}},"regulation_id_numbers":["2070-AL16"],"regulations_dot_gov_info":{"supporting_documents":[{"title":"Exposure to 6-PPD Quinone at Environmentally Relevant Concentrations Causes Abnormal Locomotion Behaviors and Neurodegeneration in Caenorhabditis elegans","document_id":"EPA-HQ-OPPT-2024-0403-0089"},{"title":"Transformation Product Formation upon Heterogeneous Ozonation of the Tire Rubber Antioxidant 6PPD (N‑(1,3-dimethylbutyl)‑N′‑phenyl‑p‑phenylenediamine)","document_id":"EPA-HQ-OPPT-2024-0403-0083"},{"title":"E‑Waste Recycling Emits Large Quantities of Emerging Aromatic Amines and Organophosphites: A Poorly Recognized Source for Another Two Classes of Synthetic Antioxidants","document_id":"EPA-HQ-OPPT-2024-0403-0080"},{"title":"Acute Toxicity of 6PPD Quinone to Early Life Stage Juvenile Chinook  (Oncorhynchus tshawytscha) and Coho (Oncorhynchus kisutch) Salmon","document_id":"EPA-HQ-OPPT-2024-0403-0079"},{"title":"Polyethylene Nanoparticles at Environmentally Relevant Concentrations Enhances Neurotoxicity and Accumulation of 6-PPD Quinone in Caenorhabditis elegans","document_id":"EPA-HQ-OPPT-2024-0403-0077"},{"title":"Widespread Occurrence of Two Typical N-substituted p-phenylenediamines and Their Quinones in Humans: Association with Oxidative Stress and Liver Damage","document_id":"EPA-HQ-OPPT-2024-0403-0075"},{"title":"The Tire-Derived Chemical 6PPD-quinone Is Lethally Toxic to the White-Spotted Char Salvelinus leucomaenis pluvius but Not to Two Other Salmonid Species","document_id":"EPA-HQ-OPPT-2024-0403-0074"},{"title":"Laws and Regulations: Listing Motor Vehicle Tires Containing N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) as a Priority Product","document_id":"EPA-HQ-OPPT-2024-0403-0066"},{"title":"Widespread Occurrence and Transport of p‑Phenylenediamines and Their Quinones in Sediments across Urban Rivers, Estuaries, Coasts, and Deep-Sea Regions","document_id":"EPA-HQ-OPPT-2024-0403-0061"},{"title":"Tire Wear Particles in the Aquatic Environment - A Review on Generation, Analysis, Occurrence, Fate and Effects","document_id":"EPA-HQ-OPPT-2024-0403-0060"}],"regulatory_plan":{"html_url":"https://www.federalregister.gov/regulations/2070-AL16/regulatory-investigation-of-n-1-3-dimethylbutyl-n-phenyl-p-phenylenediamine-6ppd-and-its-transformat","title":"Regulatory Investigation of N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (\"6PPD\") and its Transformation Product, 6PPD-quinone Under the Toxic Substances Control Act (TSCA) "},"comments_count":0,"agency_id":"EPA","comments_url":"https://www.regulations.gov/docketBrowser?rpp=50&so=DESC&sb=postedDate&po=0&dct=PS&D=EPA-HQ-OPPT-2024-0403","supporting_documents_count":90,"docket_id":"EPA-HQ-OPPT-2024-0403","document_id":"EPA-HQ-OPPT-2024-0403-0097","regulation_id_number":"2070-AL16","title":"N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product, 6PPD-quinone; Regulatory Investigation under the Toxic Substances Control Act (TSCA)","checked_regulationsdotgov_at":"2025-01-22T13:00:04Z"},"regulations_dot_gov_url":null,"significant":false,"signing_date":null,"start_page":5798,"subtype":null,"title":"N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product, 6PPD-quinone; Regulatory Investigation under the Toxic Substances Control Act (TSCA); Extension of the Comment Period","toc_doc":"N-(1,3-Dimethylbutyl)-N-phenyl-p-phenylenediamine (6PPD) and its transformation product, 6PPD-quinone","toc_subject":"Toxic Substances Control Act","topics":["Chemicals","Environmental protection","Exports","Hazardous substances","Imports","Reporting and recordkeeping requirements"],"type":"Proposed Rule","volume":90}