{"abstract":"This regulation establishes an exemption from the requirement of a tolerance for residues of l-arginine (CAS Reg. No. 74-79-3) when used as an inert ingredient (protein stabilizer) on greenhouse pre- bloom cucumbers at a maximum concentration of <=1%. D. O'Shaughnessy Consulting, Inc. on behalf of A&L Biological Inc. submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting establishment of an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of l-arginine, when used in accordance with the terms of those exemptions.","action":"Final rule.","agencies":[{"raw_name":"ENVIRONMENTAL PROTECTION AGENCY","name":"Environmental Protection Agency","id":145,"url":"https://www.federalregister.gov/agencies/environmental-protection-agency","json_url":"https://www.federalregister.gov/api/v1/agencies/145","parent_id":null,"slug":"environmental-protection-agency"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2025/05/14/2025-08508.html","cfr_references":[{"chapter":null,"citation_url":null,"part":"180","title":40}],"citation":"90 FR 20396","comment_url":null,"comments_close_on":null,"correction_of":null,"corrections":[],"dates":"This regulation is effective May 14, 2025. Objections and requests for hearings must be received on or before July 14, 2025, and must be filed in accordance with the instructions provided in 40 CFR part 178 (see also Unit I.C. of this document).","disposition_notes":null,"docket_ids":["EPA-HQ-OPP-2024-0347","FRL-12727-01-OCSPP"],"dockets":[{"supporting_documents":[{"title":"IN-11881; L-Arginine. Human Health Risk Assessment and Ecological Effects Assessment to Support Inert Ingredient Approval for use in Pesticide Formulations","document_id":"EPA-HQ-OPP-2024-0347-0004"},{"title":"A&L Biological, Inc., Co. No. 100343 Notice of Filing Petition Number IN-11881 to establish an exemption from the requirement of a tolerance for: L-Arginine in or on the raw agricultural commodity greenhouse cucumber when applied\npre-bloom as a component of a biological pesticide at a concentration","document_id":"EPA-HQ-OPP-2024-0347-0002"}],"agency_name":"EPA","documents":[{"comment_count":3,"comment_start_date":"2025-05-14","updated_at":"2025-07-15T01:56:18.523-04:00","comment_url":"https://www.regulations.gov/commenton/EPA-HQ-OPP-2024-0347-0003","allow_late_comments":false,"id":"EPA-HQ-OPP-2024-0347-0003","comment_end_date":"2025-07-15","regulations_dot_gov_open_for_comment":false}],"supporting_documents_count":2,"id":"EPA-HQ-OPP-2024-0347","title":"IN-11881; L-Arginine"}],"document_number":"2025-08508","effective_on":"2025-05-14","end_page":20400,"executive_order_notes":null,"executive_order_number":null,"full_text_xml_url":"https://www.federalregister.gov/documents/full_text/xml/2025/05/14/2025-08508.xml","html_url":"https://www.federalregister.gov/documents/2025/05/14/2025-08508/l-arginine-in-pesticide-formulations-exemption-from-the-requirement-for-a-tolerance","images":{},"images_metadata":{},"json_url":"https://www.federalregister.gov/api/v1/documents/2025-08508?publication_date=2025-05-14","mods_url":"https://www.govinfo.gov/metadata/granule/FR-2025-05-14/2025-08508/mods.xml","not_received_for_publication":null,"page_length":5,"page_views":{"count":405,"last_updated":"2026-06-24 22:15:04 -0400"},"pdf_url":"https://www.govinfo.gov/content/pkg/FR-2025-05-14/pdf/2025-08508.pdf","presidential_document_number":null,"proclamation_number":null,"public_inspection_pdf_url":"https://public-inspection.federalregister.gov/2025-08508.pdf?1747140322","publication_date":"2025-05-14","raw_text_url":"https://www.federalregister.gov/documents/full_text/text/2025/05/14/2025-08508.txt","regulation_id_number_info":{},"regulation_id_numbers":[],"regulations_dot_gov_info":{"supporting_documents":[{"title":"IN-11881; L-Arginine. Human Health Risk Assessment and Ecological Effects Assessment to Support Inert Ingredient Approval for use in Pesticide Formulations","document_id":"EPA-HQ-OPP-2024-0347-0004"},{"title":"A&L Biological, Inc., Co. No. 100343 Notice of Filing Petition Number IN-11881 to establish an exemption from the requirement of a tolerance for: L-Arginine in or on the raw agricultural commodity greenhouse cucumber when applied\npre-bloom as a component of a biological pesticide at a concentration","document_id":"EPA-HQ-OPP-2024-0347-0002"}],"comments_count":3,"agency_id":"EPA","comments_url":"https://www.regulations.gov/docketBrowser?rpp=50&so=DESC&sb=postedDate&po=0&dct=PS&D=EPA-HQ-OPP-2024-0347","supporting_documents_count":2,"docket_id":"EPA-HQ-OPP-2024-0347","document_id":"EPA-HQ-OPP-2024-0347-0003","regulation_id_number":null,"title":"IN-11881; L-Arginine","checked_regulationsdotgov_at":"2025-07-16T08:55:02Z"},"regulations_dot_gov_url":null,"significant":null,"signing_date":null,"start_page":20396,"subtype":null,"title":"L-Arginine in Pesticide Formulations; Exemption From the Requirement for a Tolerance","toc_doc":"L-Arginine in Pesticide Formulations","toc_subject":"Pesticide Tolerance; Exemptions, Petitions, Revocations, etc.","topics":["Administrative practice and procedure","Agricultural commodities","Environmental protection","Pesticides and pests","Reporting and recordkeeping requirements"],"type":"Rule","volume":90}