{"abstract":"The Environmental Protection Agency (EPA or \"Agency\") is announcing the availability of and soliciting public comment on materials that are being submitted to the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) Scientific Advisory Panel (SAP) for peer review on \"Determining the Absence of Novel Proteins in the Saliva of Genetically Engineered Mosquitoes for Mosquito Control.\" The white paper, charge questions, background documents, and related supporting materials are available for public review and comment. The FIFRA SAP will consider and review the documents at a 3-day virtual public meeting that was previously announced in the Federal Register of July 24, 2025. The virtual public meeting will be held on November 3-5, 2025, via a webcast platform such as \"Zoomgov.com\" and audio teleconference.","action":"Notice.","agencies":[{"raw_name":"ENVIRONMENTAL PROTECTION AGENCY","name":"Environmental Protection Agency","id":145,"url":"https://www.federalregister.gov/agencies/environmental-protection-agency","json_url":"https://www.federalregister.gov/api/v1/agencies/145","parent_id":null,"slug":"environmental-protection-agency"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2025/08/21/2025-15950.html","cfr_references":[],"citation":"90 FR 40829","comment_url":null,"comments_close_on":null,"correction_of":null,"corrections":[],"dates":"The following is a chronological listing of the dates for the specific activities that are described in more detail under SUPPLEMENTARY INFORMATION.","disposition_notes":null,"docket_ids":["EPA-HQ-OPP-2025-0756","FRL-12903-02-OCSPP"],"dockets":[{"supporting_documents":[{"title":"USEPA, Biosketches for Selected Ad Hoc Peer Reviewers for FIFRA Scientific Advisory Panel (SAP) for Determining the Absence of Novel Proteins in the Saliva of Genetically Engineered Mosquitoes for Mosquito Control","document_id":"EPA-HQ-OPP-2025-0756-0029"},{"title":"USEPA, Roster for FIFRA Scientific Advisory Panel (SAP) for Determining the Absence of Novel Proteins in the Saliva of Genetically Engineered Mosquitoes for Mosquito Control","document_id":"EPA-HQ-OPP-2025-0756-0028"},{"title":"Extraction of female Aedes aegypti and Anopheles albimanus saliva and preparation of test and reference substances for determination of tTAV, DsRed2, and salivary antigen D7 protein content using mass spectrometry. April 2024.","document_id":"EPA-HQ-OPP-2025-0756-0015"},{"title":"Validation of LC-MS limit test method for the detection of DsRed2, D7 and tTAV in Aedes aegypti Saliva Extracts from Latin Wild Type (WT) and Transgenic (GM) OX5034 Female Adults MRID 52595804. March 2024.","document_id":"EPA-HQ-OPP-2025-0756-0014"},{"title":"Limit test determination of tTAV and DsRed2 in Aedes Aegypti saliva extracts from Latin wild type (WT) and transgenic (GM) OX5034 female adults using LC-HRMS MRID 52595801. March 2024.","document_id":"EPA-HQ-OPP-2025-0756-0013"},{"title":"Supporting information for “Limit test determination of DsRed2 and tTAV in Aedes aegypti saliva extracts from Latin wild type (WT) and transgenic (GM) OX5034 female adults using LC-MS\" (MRID 51361705)","document_id":"EPA-HQ-OPP-2025-0756-0012"},{"title":"Limit test determination of DsRed2 and tTAV in Aedes aegypti saliva extracts from Latin wild type (WT) and transgenic (GM) OX5034 female adults using LC-MS","document_id":"EPA-HQ-OPP-2025-0756-0011"},{"title":"White Paper -  Determining the absence of novel proteins in the saliva of genetically engineered mosquitoes for mosquito control. August 2025.","document_id":"EPA-HQ-OPP-2025-0756-0010"},{"title":"Transmission of the Documents Supporting the FIFRA Scientific Advisory Panel on Determining the Absence of Novel Proteins in the Saliva of Genetically Engineered Mosquitoes for Mosquito Control","document_id":"EPA-HQ-OPP-2025-0756-0009"},{"title":"Draft Memorandum - Analysis of novel proteins in the saliva of pesticidal genetically engineered mosquitoes for mosquito control and associated design considerations for developers. August 2025.","document_id":"EPA-HQ-OPP-2025-0756-0008"}],"agency_name":"EPA","documents":[{"comment_count":6,"comment_start_date":"2025-08-21","updated_at":"2025-10-01T01:56:36.898-04:00","comment_url":"https://www.regulations.gov/commenton/EPA-HQ-OPP-2025-0756-0005","allow_late_comments":false,"id":"EPA-HQ-OPP-2025-0756-0005","comment_end_date":"2025-09-23","regulations_dot_gov_open_for_comment":false}],"supporting_documents_count":13,"id":"EPA-HQ-OPP-2025-0756","title":"Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel Review of Determining the Absence of Novel Proteins in the Saliva of Genetically Engineered Mosquitoes for Mosquito Control"}],"document_number":"2025-15950","effective_on":null,"end_page":40831,"executive_order_notes":null,"executive_order_number":null,"explanation":null,"full_text_xml_url":"https://www.federalregister.gov/documents/full_text/xml/2025/08/21/2025-15950.xml","html_url":"https://www.federalregister.gov/documents/2025/08/21/2025-15950/fifra-scientific-advisory-panel-sap-determining-the-absence-of-novel-proteins-in-the-saliva-of","images":{},"images_metadata":{},"json_url":"https://www.federalregister.gov/api/v1/documents/2025-15950?publication_date=2025-08-21","mods_url":"https://www.govinfo.gov/metadata/granule/FR-2025-08-21/2025-15950/mods.xml","not_received_for_publication":null,"page_length":3,"page_views":{"count":259,"last_updated":"2026-04-04 14:15:05 -0400"},"pdf_url":"https://www.govinfo.gov/content/pkg/FR-2025-08-21/pdf/2025-15950.pdf","presidential_document_number":null,"proclamation_number":null,"public_inspection_pdf_url":"https://public-inspection.federalregister.gov/2025-15950.pdf?1755693945","publication_date":"2025-08-21","raw_text_url":"https://www.federalregister.gov/documents/full_text/text/2025/08/21/2025-15950.txt","regulation_id_number_info":{},"regulation_id_numbers":[],"regulations_dot_gov_info":{"supporting_documents":[{"title":"Extraction of female Aedes aegypti and Anopheles albimanus saliva and preparation of test and reference substances for determination of tTAV, DsRed2, and salivary antigen D7 protein content using mass spectrometry. April 2024.","document_id":"EPA-HQ-OPP-2025-0756-0015"},{"title":"Validation of LC-MS limit test method for the detection of DsRed2, D7 and tTAV in Aedes aegypti Saliva Extracts from Latin Wild Type (WT) and Transgenic (GM) OX5034 Female Adults MRID 52595804. March 2024.","document_id":"EPA-HQ-OPP-2025-0756-0014"},{"title":"Limit test determination of tTAV and DsRed2 in Aedes Aegypti saliva extracts from Latin wild type (WT) and transgenic (GM) OX5034 female adults using LC-HRMS MRID 52595801. March 2024.","document_id":"EPA-HQ-OPP-2025-0756-0013"},{"title":"Supporting information for “Limit test determination of DsRed2 and tTAV in Aedes aegypti saliva extracts from Latin wild type (WT) and transgenic (GM) OX5034 female adults using LC-MS\" (MRID 51361705)","document_id":"EPA-HQ-OPP-2025-0756-0012"},{"title":"Limit test determination of DsRed2 and tTAV in Aedes aegypti saliva extracts from Latin wild type (WT) and transgenic (GM) OX5034 female adults using LC-MS","document_id":"EPA-HQ-OPP-2025-0756-0011"},{"title":"White Paper -  Determining the absence of novel proteins in the saliva of genetically engineered mosquitoes for mosquito control. August 2025.","document_id":"EPA-HQ-OPP-2025-0756-0010"},{"title":"Transmission of the Documents Supporting the FIFRA Scientific Advisory Panel on Determining the Absence of Novel Proteins in the Saliva of Genetically Engineered Mosquitoes for Mosquito Control","document_id":"EPA-HQ-OPP-2025-0756-0009"},{"title":"Draft Memorandum - Analysis of novel proteins in the saliva of pesticidal genetically engineered mosquitoes for mosquito control and associated design considerations for developers. August 2025.","document_id":"EPA-HQ-OPP-2025-0756-0008"},{"title":"EPA BPPD Request that Oxitec Disclaim Confidentiality for Specified Documents","document_id":"EPA-HQ-OPP-2025-0756-0007"},{"title":"Charge Questions. August 2025","document_id":"EPA-HQ-OPP-2025-0756-0006"}],"comments_count":6,"agency_id":"EPA","comments_url":"https://www.regulations.gov/docketBrowser?rpp=50&so=DESC&sb=postedDate&po=0&dct=PS&D=EPA-HQ-OPP-2025-0756","supporting_documents_count":11,"docket_id":"EPA-HQ-OPP-2025-0756","document_id":"EPA-HQ-OPP-2025-0756-0005","regulation_id_number":null,"title":"Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel Review of Determining the Absence of Novel Proteins in the Saliva of Genetically Engineered Mosquitoes for Mosquito Control","checked_regulationsdotgov_at":"2025-10-02T08:55:04Z"},"regulations_dot_gov_url":null,"significant":null,"signing_date":null,"start_page":40829,"subtype":null,"title":"FIFRA Scientific Advisory Panel (SAP); Determining the Absence of Novel Proteins in the Saliva of Genetically Engineered Mosquitoes for Mosquito Control; Notice of Availability, and Request for Comment","toc_doc":"Determining the Absence of Novel Proteins in the Saliva of Genetically Engineered Mosquitoes for Mosquito Control","toc_subject":"FIFRA Scientific Advisory Panel","topics":[],"type":"Notice","volume":90}