{"abstract":"The U.S. Environmental Protection Agency (EPA, \"the Agency\") is proposing to amend the procedural framework rule for conducting existing chemical risk evaluations under the Toxic Substances Control Act (TSCA). When conducting an existing chemical risk evaluation under TSCA, EPA must determine whether a chemical substance presents an unreasonable risk of injury to health or the environment, without consideration of costs or non-risk factors, including unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant to the risk evaluation, under the conditions of use. In this action, EPA proposes to rescind or revise certain 2024 amendments to the procedural framework rule to effectuate the best reading of the statute and ensure that the procedural framework rule does not impede the timely completion of risk evaluations or impair the effective and efficient protection of health and the environment.","action":"Proposed rule.","agencies":[{"raw_name":"ENVIRONMENTAL PROTECTION AGENCY","name":"Environmental Protection Agency","id":145,"url":"https://www.federalregister.gov/agencies/environmental-protection-agency","json_url":"https://www.federalregister.gov/api/v1/agencies/145","parent_id":null,"slug":"environmental-protection-agency"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2025/09/23/2025-18431.html","cfr_references":[{"chapter":null,"citation_url":null,"part":"702","title":40}],"citation":"90 FR 45690","comment_url":null,"comments_close_on":"2025-11-07","correction_of":null,"corrections":[],"dates":"Comments must be received on or before November 7, 2025. Under the Paperwork Reduction Act, comments on the information collection provisions are best assured of consideration if the Office of Management and Budget (OMB) receives a copy of your comments on or before October 23, 2025.","disposition_notes":null,"docket_ids":["EPA-HQ-OPPT-2025-0260","FRL-8529.1-01-OCSPP"],"dockets":[{"supporting_documents":[{"title":"EPA Response to United Steelworkers Request to Extend Public Comment Period. October 9, 2025.","document_id":"EPA-HQ-OPPT-2025-0260-0065"},{"title":"EPA Response to American Federation of Labor and Congress of Industrial Organizations Request to Extend Public Comment Period. October 9, 2025.","document_id":"EPA-HQ-OPPT-2025-0260-0064"},{"title":"Problem Formulation of the Risk Evaluation for 1,4-Dioxane (2018)","document_id":"EPA-HQ-OPPT-2025-0260-0051"},{"title":"Risk Evaluation Rule User Guide – Primary Authorized Official","document_id":"EPA-HQ-OPPT-2025-0260-0048"},{"title":"Office of Management and Budget, Memorandum M-19-15, Memorandum for the Heads of Executive Departments and Agencies: Improving Implementation of the Information Quality Act,  April 24th, 2019","document_id":"EPA-HQ-OPPT-2025-0260-0047"},{"title":"Risk Evaluation for Trichloroethylene (November 2020)","document_id":"EPA-HQ-OPPT-2025-0260-0046"},{"title":"Risk Evaluation for Perchloroethylene (December 2020)","document_id":"EPA-HQ-OPPT-2025-0260-0045"},{"title":"Respondent EPA's Brief in the 9th Circuit Court of Appeals, No. 17-72260, August 6, 2018","document_id":"EPA-HQ-OPPT-2025-0260-0044"},{"title":"EPA Peer Review Handbook, 4th Edition, October 2015","document_id":"EPA-HQ-OPPT-2025-0260-0041"},{"title":"Draft Risk Evaluation for 1,4-Dioxane, June 2019","document_id":"EPA-HQ-OPPT-2025-0260-0039"}],"agency_name":"EPA","documents":[{"comment_count":26339,"comment_start_date":"2025-09-23","updated_at":"2025-12-20T00:56:36.500-05:00","comment_url":"https://www.regulations.gov/commenton/EPA-HQ-OPPT-2025-0260-0001","allow_late_comments":false,"id":"EPA-HQ-OPPT-2025-0260-0001","comment_end_date":"2025-11-08","regulations_dot_gov_open_for_comment":false}],"supporting_documents_count":57,"id":"EPA-HQ-OPPT-2025-0260","title":"Procedures for Chemical Risk Evaluation Under the Toxic Substances Control Act (TSCA)"}],"document_number":"2025-18431","effective_on":null,"end_page":45717,"executive_order_notes":null,"executive_order_number":null,"full_text_xml_url":"https://www.federalregister.gov/documents/full_text/xml/2025/09/23/2025-18431.xml","html_url":"https://www.federalregister.gov/documents/2025/09/23/2025-18431/procedures-for-chemical-risk-evaluation-under-the-toxic-substances-control-act-tsca","images":{},"images_metadata":{},"json_url":"https://www.federalregister.gov/api/v1/documents/2025-18431?publication_date=2025-09-23","mods_url":"https://www.govinfo.gov/metadata/granule/FR-2025-09-23/2025-18431/mods.xml","not_received_for_publication":null,"page_length":28,"page_views":{"count":6655,"last_updated":"2026-10-24 10:15:05 -0400"},"pdf_url":"https://www.govinfo.gov/content/pkg/FR-2025-09-23/pdf/2025-18431.pdf","presidential_document_number":null,"proclamation_number":null,"public_inspection_pdf_url":"https://public-inspection.federalregister.gov/2025-18431.pdf?1758545119","publication_date":"2025-09-23","raw_text_url":"https://www.federalregister.gov/documents/full_text/text/2025/09/23/2025-18431.txt","regulation_id_number_info":{"2070-AL27":{"issue":"202504","html_url":"https://www.federalregister.gov/regulations/2070-AL27/further-reconsideration-of-procedures-for-chemical-risk-evaluation-under-the-toxic-substances-contro","title":"Further Reconsideration of Procedures for Chemical Risk Evaluation Under the Toxic Substances Control Act (TSCA)","xml_url":"http://www.reginfo.gov/public/do/eAgendaViewRule?pubId=202504&RIN=2070-AL27&operation=OPERATION_EXPORT_XML","priority_category":"Other Significant"}},"regulation_id_numbers":["2070-AL27"],"regulations_dot_gov_info":{"supporting_documents":[{"title":"EPA Response to United Steelworkers Request to Extend Public Comment Period. October 9, 2025.","document_id":"EPA-HQ-OPPT-2025-0260-0065"},{"title":"EPA Response to American Federation of Labor and Congress of Industrial Organizations Request to Extend Public Comment Period. October 9, 2025.","document_id":"EPA-HQ-OPPT-2025-0260-0064"},{"title":"Problem Formulation of the Risk Evaluation for 1,4-Dioxane (2018)","document_id":"EPA-HQ-OPPT-2025-0260-0051"},{"title":"Risk Evaluation Rule User Guide – Primary Authorized Official","document_id":"EPA-HQ-OPPT-2025-0260-0048"},{"title":"Office of Management and Budget, Memorandum M-19-15, Memorandum for the Heads of Executive Departments and Agencies: Improving Implementation of the Information Quality Act,  April 24th, 2019","document_id":"EPA-HQ-OPPT-2025-0260-0047"},{"title":"Risk Evaluation for Trichloroethylene (November 2020)","document_id":"EPA-HQ-OPPT-2025-0260-0046"},{"title":"Risk Evaluation for Perchloroethylene (December 2020)","document_id":"EPA-HQ-OPPT-2025-0260-0045"},{"title":"Respondent EPA's Brief in the 9th Circuit Court of Appeals, No. 17-72260, August 6, 2018","document_id":"EPA-HQ-OPPT-2025-0260-0044"},{"title":"EPA Peer Review Handbook, 4th Edition, October 2015","document_id":"EPA-HQ-OPPT-2025-0260-0041"},{"title":"Draft Risk Evaluation for 1,4-Dioxane, June 2019","document_id":"EPA-HQ-OPPT-2025-0260-0039"}],"regulatory_plan":{"html_url":"https://www.federalregister.gov/regulations/2070-AL27/further-reconsideration-of-procedures-for-chemical-risk-evaluation-under-the-toxic-substances-contro","title":"Further Reconsideration of Procedures for Chemical Risk Evaluation Under the Toxic Substances Control Act (TSCA)"},"comments_count":26339,"agency_id":"EPA","comments_url":"https://www.regulations.gov/docketBrowser?rpp=50&so=DESC&sb=postedDate&po=0&dct=PS&D=EPA-HQ-OPPT-2025-0260","supporting_documents_count":57,"docket_id":"EPA-HQ-OPPT-2025-0260","document_id":"EPA-HQ-OPPT-2025-0260-0001","regulation_id_number":"2070-AL27","title":"Procedures for Chemical Risk Evaluation Under the Toxic Substances Control Act (TSCA)","checked_regulationsdotgov_at":"2025-12-21T09:55:08Z"},"regulations_dot_gov_url":null,"significant":true,"signing_date":null,"start_page":45690,"subtype":null,"title":"Procedures for Chemical Risk Evaluation Under the Toxic Substances Control Act (TSCA)","toc_doc":"Procedures for Chemical Risk Evaluation","toc_subject":"Toxic Substances Control Act","topics":["Chemicals","Environmental protection","Hazardous substances"],"type":"Proposed Rule","volume":90}