{"abstract":"This regulation establishes tolerances for residues of isocycloseram (CASRN 2061933-85-3) in or on multiple commodities which are identified and discussed later in this document. Under the Federal Food, Drug, and Cosmetic Act (FFDCA), Syngenta Crop Protection, LLC submitted a petition to EPA requesting that EPA establish a maximum permissible level for residues of this pesticide in or on the identified commodities.","action":"Final rule.","agencies":[{"raw_name":"ENVIRONMENTAL PROTECTION AGENCY","name":"Environmental Protection Agency","id":145,"url":"https://www.federalregister.gov/agencies/environmental-protection-agency","json_url":"https://www.federalregister.gov/api/v1/agencies/145","parent_id":null,"slug":"environmental-protection-agency"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2025/11/20/2025-20460.html","cfr_references":[{"chapter":null,"citation_url":null,"part":180,"title":40}],"citation":"90 FR 52256","comment_url":null,"comments_close_on":null,"correction_of":null,"corrections":[],"dates":"This regulation is effective November 20, 2025. Objections and requests for hearings must be received on or before January 20, 2026 and must be filed in accordance with the instructions provided in 40 CFR part 178 (see also Unit I.C. of this document).","disposition_notes":null,"docket_ids":["EPA-HQ-OPP-2021-0641","FRL-13015-01-OCSPP"],"dockets":[{"supporting_documents":[{"title":"Final Environmental Fate and Ecological Risk Assessment (ERA) and Biological Evaluation (BE) with Associated Effects Determinations for Federally Listed Endangered and Threatened Species and Designated Critical Habitat for the\nSection 3 Registration of the New Active Ingredient Isocycloseram","document_id":"EPA-HQ-OPP-2021-0641-0311"},{"title":"Response to Public Comments on EPA’s Registration of the New Active Ingredient, Isocycloseram","document_id":"EPA-HQ-OPP-2021-0641-0310"},{"title":"Memorandum Supporting Final Decision to Approve Registration for the New Active Ingredient of Isocycloseram","document_id":"EPA-HQ-OPP-2021-0641-0309"},{"title":"Isocycloseram. Addendum to the Occupational and Residential Exposure Assessment for the New Active Ingredient Isocycloseram for Updated Commercial Seed Treatment Uses","document_id":"EPA-HQ-OPP-2021-0641-0308"},{"title":"Isocycloseram. Petition for the Establishment of Permanent Tolerances and Registration for New Use on Tree Nuts (Crop Group 14-12). Addendum to the Summary of Analytical Chemistry Residue Data and Dietary Exposure Assessment","document_id":"EPA-HQ-OPP-2021-0641-0307"},{"title":"Isocycloseram Atexzo Alternate Brand Name: Vykenda - Master Label","document_id":"EPA-HQ-OPP-2021-0641-0031"},{"title":"Isocycloseram A22128 Cockroach Gel Bait - Master Label","document_id":"EPA-HQ-OPP-2021-0641-0029"},{"title":"Isocycloseram Alternate Brand Name: Equento 100FS A22241 ST","document_id":"EPA-HQ-OPP-2021-0641-0028"},{"title":"Isocycloseram Alternate Brand Name: Equento 400FS A22725 ST - Master Label","document_id":"EPA-HQ-OPP-2021-0641-0027"},{"title":"Isocycloseram A21708 CP For control of mites, thrips, true bugs, lepidopterous pests, and other insects in Brassica Head\nand Stem Vegetables, Crop Group 5-16; Brassica Leafy Greens, Crop Subgroup 4-16B - Master Label","document_id":"EPA-HQ-OPP-2021-0641-0026"}],"agency_name":"EPA","documents":[{"comment_count":46,"comment_start_date":"2025-11-20","updated_at":"2026-01-25T00:56:07.142-05:00","comment_url":"https://www.regulations.gov/commenton/EPA-HQ-OPP-2021-0641-0305","allow_late_comments":false,"id":"EPA-HQ-OPP-2021-0641-0305","comment_end_date":"2026-01-21","regulations_dot_gov_open_for_comment":false}],"supporting_documents_count":34,"id":"EPA-HQ-OPP-2021-0641","title":"Isocycloseram; New Active Ingredient"}],"document_number":"2025-20460","effective_on":"2025-11-20","end_page":52263,"executive_order_notes":null,"executive_order_number":null,"explanation":null,"full_text_xml_url":"https://www.federalregister.gov/documents/full_text/xml/2025/11/20/2025-20460.xml","html_url":"https://www.federalregister.gov/documents/2025/11/20/2025-20460/isocycloseram-pesticide-tolerances","images":{},"images_metadata":{},"json_url":"https://www.federalregister.gov/api/v1/documents/2025-20460?publication_date=2025-11-20","mods_url":"https://www.govinfo.gov/metadata/granule/FR-2025-11-20/2025-20460/mods.xml","not_received_for_publication":null,"page_length":8,"page_views":{"count":1100,"last_updated":"2026-04-04 18:15:03 -0400"},"pdf_url":"https://www.govinfo.gov/content/pkg/FR-2025-11-20/pdf/2025-20460.pdf","presidential_document_number":null,"proclamation_number":null,"public_inspection_pdf_url":"https://public-inspection.federalregister.gov/2025-20460.pdf?1763559928","publication_date":"2025-11-20","raw_text_url":"https://www.federalregister.gov/documents/full_text/text/2025/11/20/2025-20460.txt","regulation_id_number_info":{},"regulation_id_numbers":[],"regulations_dot_gov_info":{"supporting_documents":[{"title":"Final Environmental Fate and Ecological Risk Assessment (ERA) and Biological Evaluation (BE) with Associated Effects Determinations for Federally Listed Endangered and Threatened Species and Designated Critical Habitat for the\nSection 3 Registration of the New Active Ingredient Isocycloseram","document_id":"EPA-HQ-OPP-2021-0641-0311"},{"title":"Response to Public Comments on EPA’s Registration of the New Active Ingredient, Isocycloseram","document_id":"EPA-HQ-OPP-2021-0641-0310"},{"title":"Memorandum Supporting Final Decision to Approve Registration for the New Active Ingredient of Isocycloseram","document_id":"EPA-HQ-OPP-2021-0641-0309"},{"title":"Isocycloseram. Addendum to the Occupational and Residential Exposure Assessment for the New Active Ingredient Isocycloseram for Updated Commercial Seed Treatment Uses","document_id":"EPA-HQ-OPP-2021-0641-0308"},{"title":"Isocycloseram. Petition for the Establishment of Permanent Tolerances and Registration for New Use on Tree Nuts (Crop Group 14-12). Addendum to the Summary of Analytical Chemistry Residue Data and Dietary Exposure Assessment","document_id":"EPA-HQ-OPP-2021-0641-0307"},{"title":"Isocycloseram Atexzo Alternate Brand Name: Vykenda - Master Label","document_id":"EPA-HQ-OPP-2021-0641-0031"},{"title":"Isocycloseram A22128 Cockroach Gel Bait - Master Label","document_id":"EPA-HQ-OPP-2021-0641-0029"},{"title":"Isocycloseram Alternate Brand Name: Equento 100FS A22241 ST","document_id":"EPA-HQ-OPP-2021-0641-0028"},{"title":"Isocycloseram Alternate Brand Name: Equento 400FS A22725 ST - Master Label","document_id":"EPA-HQ-OPP-2021-0641-0027"},{"title":"Isocycloseram A21708 CP For control of mites, thrips, true bugs, lepidopterous pests, and other insects in Brassica Head\nand Stem Vegetables, Crop Group 5-16; Brassica Leafy Greens, Crop Subgroup 4-16B - Master Label","document_id":"EPA-HQ-OPP-2021-0641-0026"}],"comments_count":46,"agency_id":"EPA","comments_url":"https://www.regulations.gov/docketBrowser?rpp=50&so=DESC&sb=postedDate&po=0&dct=PS&D=EPA-HQ-OPP-2021-0641","supporting_documents_count":34,"docket_id":"EPA-HQ-OPP-2021-0641","document_id":"EPA-HQ-OPP-2021-0641-0305","regulation_id_number":null,"title":"Isocycloseram; New Active Ingredient","checked_regulationsdotgov_at":"2026-01-25T12:55:04Z"},"regulations_dot_gov_url":null,"significant":null,"signing_date":null,"start_page":52256,"subtype":null,"title":"Isocycloseram; Pesticide Tolerances","toc_doc":"Isocycloseram","toc_subject":"Pesticide Tolerance; Exemptions, Petitions, Revocations, etc.","topics":["Administrative practice and procedure","Agricultural commodities","Environmental protection","Pesticides and pests","Reporting and recordkeeping requirements"],"type":"Rule","volume":90}