{"abstract":"The Food and Drug Administration (FDA, the Agency, or we) is announcing a request for information from interested parties and the public to share their perspectives with FDA on testosterone replacement therapy for men. The Agency intends to use the information submitted to help inform considerations related to testosterone therapy for men.","action":"Notice; request for information.","agencies":[{"raw_name":"DEPARTMENT OF HEALTH AND HUMAN SERVICES","name":"Health and Human Services Department","id":221,"url":"https://www.federalregister.gov/agencies/health-and-human-services-department","json_url":"https://www.federalregister.gov/api/v1/agencies/221","parent_id":null,"slug":"health-and-human-services-department"},{"raw_name":"Food and Drug Administration","name":"Food and Drug Administration","id":199,"url":"https://www.federalregister.gov/agencies/food-and-drug-administration","json_url":"https://www.federalregister.gov/api/v1/agencies/199","parent_id":221,"slug":"food-and-drug-administration"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2025/12/11/2025-22466.html","cfr_references":[],"citation":"90 FR 57474","comment_url":null,"comments_close_on":"2026-02-09","correction_of":null,"corrections":[],"dates":"Either electronic or written comments on the notice must be submitted by February 9, 2026.","disposition_notes":null,"docket_ids":["Docket No. FDA-2025-N-6743"],"dockets":[{"supporting_documents":[{"title":"Effects of Testosterone Treatment in Older Men","document_id":"FDA-2025-N-6743-2004"},{"title":"Effect of Testosterone Replacement Therapy on Sexual Function and Hypogonadal Symptoms in Men with Hypogonadism","document_id":"FDA-2025-N-6743-2003"}],"agency_name":"FDA","documents":[{"comment_count":2000,"comment_start_date":"2025-12-11","updated_at":"2026-02-21T00:57:13.556-05:00","comment_url":"https://www.regulations.gov/commenton/FDA-2025-N-6743-0001","allow_late_comments":false,"id":"FDA-2025-N-6743-0001","comment_end_date":"2026-02-10","regulations_dot_gov_open_for_comment":false}],"supporting_documents_count":2,"id":"FDA-2025-N-6743","title":"Food and Drug Administration Expert Panel on Testosterone Replacement Therapy for Men; Request for Information"}],"document_number":"2025-22466","effective_on":null,"end_page":57476,"executive_order_notes":null,"executive_order_number":null,"full_text_xml_url":"https://www.federalregister.gov/documents/full_text/xml/2025/12/11/2025-22466.xml","html_url":"https://www.federalregister.gov/documents/2025/12/11/2025-22466/food-and-drug-administration-expert-panel-on-testosterone-replacement-therapy-for-men-request-for","images":{},"images_metadata":{},"json_url":"https://www.federalregister.gov/api/v1/documents/2025-22466?publication_date=2025-12-11","mods_url":"https://www.govinfo.gov/metadata/granule/FR-2025-12-11/2025-22466/mods.xml","not_received_for_publication":null,"page_length":3,"page_views":{"count":10966,"last_updated":"2026-06-16 02:15:03 -0400"},"pdf_url":"https://www.govinfo.gov/content/pkg/FR-2025-12-11/pdf/2025-22466.pdf","presidential_document_number":null,"proclamation_number":null,"public_inspection_pdf_url":"https://public-inspection.federalregister.gov/2025-22466.pdf?1765374309","publication_date":"2025-12-11","raw_text_url":"https://www.federalregister.gov/documents/full_text/text/2025/12/11/2025-22466.txt","regulation_id_number_info":{},"regulation_id_numbers":[],"regulations_dot_gov_info":{"supporting_documents":[{"title":"Effects of Testosterone Treatment in Older Men","document_id":"FDA-2025-N-6743-2004"},{"title":"Effect of Testosterone Replacement Therapy on Sexual Function and Hypogonadal Symptoms in Men with Hypogonadism","document_id":"FDA-2025-N-6743-2003"}],"comments_count":2000,"agency_id":"FDA","comments_url":"https://www.regulations.gov/docketBrowser?rpp=50&so=DESC&sb=postedDate&po=0&dct=PS&D=FDA-2025-N-6743","supporting_documents_count":2,"docket_id":"FDA-2025-N-6743","document_id":"FDA-2025-N-6743-0001","regulation_id_number":null,"title":"Food and Drug Administration Expert Panel on Testosterone Replacement Therapy for Men; Request for Information","checked_regulationsdotgov_at":"2026-02-21T19:55:03Z"},"regulations_dot_gov_url":null,"significant":null,"signing_date":null,"start_page":57474,"subtype":null,"title":"Food and Drug Administration Expert Panel on Testosterone Replacement Therapy for Men; Request for Information","toc_doc":"Expert Panel on Testosterone Replacement Therapy for Men","toc_subject":"Request for Information","topics":[],"type":"Notice","volume":90}