{"abstract":"The Food and Drug Administration (FDA, the Agency, or we) is adding constituents to the list of harmful and potentially harmful constituents (HPHCs) in tobacco products and tobacco smoke (the established HPHC list) as required by the Federal Food, Drug, and Cosmetic Act (the FD&C Act).","action":"Notice; established list additions and request for comments.","agencies":[{"raw_name":"DEPARTMENT OF HEALTH AND HUMAN SERVICES","name":"Health and Human Services Department","id":221,"url":"https://www.federalregister.gov/agencies/health-and-human-services-department","json_url":"https://www.federalregister.gov/api/v1/agencies/221","parent_id":null,"slug":"health-and-human-services-department"},{"raw_name":"Food and Drug Administration","name":"Food and Drug Administration","id":199,"url":"https://www.federalregister.gov/agencies/food-and-drug-administration","json_url":"https://www.federalregister.gov/api/v1/agencies/199","parent_id":221,"slug":"food-and-drug-administration"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2026/04/23/2026-07910.html","cfr_references":[],"citation":"91 FR 21824","comment_url":"http://www.regulations.gov/commenton/FDA-2026-N-2642-0001","comments_close_on":"2026-05-26","correction_of":null,"corrections":[],"dates":"Either electronic or written comments on the notice must be submitted by May 26, 2026.","disposition_notes":null,"docket_ids":["Docket No. FDA-2026-N-2642"],"dockets":[],"document_number":"2026-07910","effective_on":null,"end_page":21829,"executive_order_notes":null,"executive_order_number":null,"explanation":null,"full_text_xml_url":"https://www.federalregister.gov/documents/full_text/xml/2026/04/23/2026-07910.xml","html_url":"https://www.federalregister.gov/documents/2026/04/23/2026-07910/harmful-and-potentially-harmful-constituents-in-tobacco-products-and-tobacco-smoke-established-list","images":{},"images_metadata":{},"json_url":"https://www.federalregister.gov/api/v1/documents/2026-07910?publication_date=2026-04-23","mods_url":"https://www.govinfo.gov/metadata/granule/FR-2026-04-23/2026-07910/mods.xml","not_received_for_publication":null,"page_length":6,"page_views":{"count":100,"last_updated":"2026-04-23 14:15:04 -0400"},"pdf_url":"https://www.govinfo.gov/content/pkg/FR-2026-04-23/pdf/2026-07910.pdf","presidential_document_number":null,"proclamation_number":null,"public_inspection_pdf_url":"https://public-inspection.federalregister.gov/2026-07910.pdf?1776861916","publication_date":"2026-04-23","raw_text_url":"https://www.federalregister.gov/documents/full_text/text/2026/04/23/2026-07910.txt","regulation_id_number_info":{},"regulation_id_numbers":[],"regulations_dot_gov_info":{"supporting_documents":[],"comments_count":0,"agency_id":"FDA","comments_url":"https://www.regulations.gov/docketBrowser?rpp=50&so=DESC&sb=postedDate&po=0&dct=PS&D=FDA-2026-N-2642","supporting_documents_count":0,"docket_id":"FDA-2026-N-2642","document_id":"FDA-2026-N-2642-0001","regulation_id_number":null,"title":"Harmful and Potentially Harmful Constituents in Tobacco Products and Tobacco Smoke; Established List Additions and Request for Comments","checked_regulationsdotgov_at":"2026-04-23T14:55:04Z"},"regulations_dot_gov_url":"http://www.regulations.gov/commenton/FDA-2026-N-2642-0001","significant":null,"signing_date":null,"start_page":21824,"subtype":null,"title":"Harmful and Potentially Harmful Constituents in Tobacco Products and Tobacco Smoke; Established List Additions and Request for Comments","toc_doc":"Harmful and Potentially Harmful Constituents in Tobacco Products and Tobacco Smoke","toc_subject":"Established List Additions","topics":[],"type":"Notice","volume":91}