{"abstract":"Scientists at the National Cancer Institute (NCI) have developed a novel tightly regulated drug-responsive, membrane-bound IL- 12 cytokine platform, that enhances anti-tumor efficacy in adoptive cell therapy (ACT) with engineered T-cells (CAR, TCR, TILs) while improving safety. The NCI seeks research co-development partners and/or licensees to advance this technology toward clinical translation.","action":"Notice.","agencies":[{"raw_name":"DEPARTMENT OF HEALTH AND HUMAN SERVICES","name":"Health and Human Services Department","id":221,"url":"https://www.federalregister.gov/agencies/health-and-human-services-department","json_url":"https://www.federalregister.gov/api/v1/agencies/221","parent_id":null,"slug":"health-and-human-services-department"},{"raw_name":"National Institutes of Health","name":"National Institutes of Health","id":353,"url":"https://www.federalregister.gov/agencies/national-institutes-of-health","json_url":"https://www.federalregister.gov/api/v1/agencies/353","parent_id":221,"slug":"national-institutes-of-health"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2026/08/12/2026-16438.html","cfr_references":[],"citation":"91 FR 52063","comment_url":null,"comments_close_on":null,"correction_of":null,"corrections":[],"dates":null,"disposition_notes":null,"docket_ids":[],"dockets":[],"document_number":"2026-16438","effective_on":null,"end_page":52063,"executive_order_notes":null,"executive_order_number":null,"full_text_xml_url":"https://www.federalregister.gov/documents/full_text/xml/2026/08/12/2026-16438.xml","html_url":"https://www.federalregister.gov/documents/2026/08/12/2026-16438/nih-owned-invention-available-for-license-drug-regulatable-inducible-expression-of-membrane-bound","images":{},"images_metadata":{},"json_url":"https://www.federalregister.gov/api/v1/documents/2026-16438?publication_date=2026-08-12","mods_url":"https://www.govinfo.gov/metadata/granule/FR-2026-08-12/2026-16438/mods.xml","not_received_for_publication":null,"page_length":1,"page_views":{"count":66,"last_updated":"2026-10-23 08:15:04 -0400"},"pdf_url":"https://www.govinfo.gov/content/pkg/FR-2026-08-12/pdf/2026-16438.pdf","presidential_document_number":null,"proclamation_number":null,"public_inspection_pdf_url":"https://public-inspection.federalregister.gov/2026-16438.pdf?1786452318","publication_date":"2026-08-12","raw_text_url":"https://www.federalregister.gov/documents/full_text/text/2026/08/12/2026-16438.txt","regulation_id_number_info":{},"regulation_id_numbers":[],"regulations_dot_gov_info":{"checked_regulationsdotgov_at":"2026-08-12T05:33:04Z"},"regulations_dot_gov_url":null,"significant":null,"signing_date":null,"start_page":52063,"subtype":null,"title":"NIH Owned Invention Available for License: Drug-Regulatable, Inducible Expression of Membrane-Bound Interleukin 12 (DRIM-IL-12) for Use in Adoptive Cell Therapy","toc_doc":"NIH Owned Invention; Drug-Regulatable, Inducible Expression of Membrane-Bound Interleukin 12 (DRIM-IL-12) for Use in Adoptive Cell Therapy","toc_subject":"Licenses; Exemptions, Applications, Amendments, etc.","topics":[],"type":"Notice","volume":91}