{"abstract":"The National Cancer Institute (NCI) seeks licensees for matched patient-derived 3D Isocitrate Dehydrogenase (IDH)-mutant glioma cell lines, 403L and 403H, generated from the same patient before and after malignant transformation from WHO grade 2 to WHO grade 4 disease. This research material provides an opportunity to study IDH-mutant glioma progression, temozolomide-associated hypermutation, invasion, metabolism, and treatment resistance.","action":"Notice.","agencies":[{"raw_name":"DEPARTMENT OF HEALTH AND HUMAN SERVICES","name":"Health and Human Services Department","id":221,"url":"https://www.federalregister.gov/agencies/health-and-human-services-department","json_url":"https://www.federalregister.gov/api/v1/agencies/221","parent_id":null,"slug":"health-and-human-services-department"},{"raw_name":"National Institutes of Health","name":"National Institutes of Health","id":353,"url":"https://www.federalregister.gov/agencies/national-institutes-of-health","json_url":"https://www.federalregister.gov/api/v1/agencies/353","parent_id":221,"slug":"national-institutes-of-health"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2026/08/21/2026-17157.html","cfr_references":[],"citation":"91 FR 54338","comment_url":null,"comments_close_on":null,"correction_of":null,"corrections":[],"dates":null,"disposition_notes":null,"docket_ids":[],"dockets":[],"document_number":"2026-17157","effective_on":null,"end_page":54338,"executive_order_notes":null,"executive_order_number":null,"full_text_xml_url":"https://www.federalregister.gov/documents/full_text/xml/2026/08/21/2026-17157.xml","html_url":"https://www.federalregister.gov/documents/2026/08/21/2026-17157/government-owned-invention-available-for-license-matched-patient-derived-3d-isocitrate-dehydrogenase","images":{},"images_metadata":{},"json_url":"https://www.federalregister.gov/api/v1/documents/2026-17157?publication_date=2026-08-21","mods_url":"https://www.govinfo.gov/metadata/granule/FR-2026-08-21/2026-17157/mods.xml","not_received_for_publication":null,"page_length":1,"page_views":{"count":85,"last_updated":"2026-10-24 14:15:04 -0400"},"pdf_url":"https://www.govinfo.gov/content/pkg/FR-2026-08-21/pdf/2026-17157.pdf","presidential_document_number":null,"proclamation_number":null,"public_inspection_pdf_url":"https://public-inspection.federalregister.gov/2026-17157.pdf?1787229922","publication_date":"2026-08-21","raw_text_url":"https://www.federalregister.gov/documents/full_text/text/2026/08/21/2026-17157.txt","regulation_id_number_info":{},"regulation_id_numbers":[],"regulations_dot_gov_info":{"checked_regulationsdotgov_at":"2026-08-21T08:49:57Z"},"regulations_dot_gov_url":null,"significant":null,"signing_date":null,"start_page":54338,"subtype":null,"title":"Government Owned Invention Available for License: Matched Patient-Derived 3D Isocitrate Dehydrogenase (IDH)-Mutant Glioma Cell Lines for Modeling Malignant Transformation","toc_doc":"Government Owned Invention; Matched Patient-Derived 3D Isocitrate Dehydrogenase-Mutant Glioma Cell Lines for Modeling Malignant Transformation","toc_subject":"Licenses; Exemptions, Applications, Amendments, etc.","topics":[],"type":"Notice","volume":91}