{"abstract":"The Administrator of the Drug Enforcement Administration (DEA) is issuing this notice of intent to publish a temporary order to schedule 7-hydroxymitragynine and mitragynine pseudoindoxyl (including their isomers, esters, ethers, salts, and salts of isomers, esters, and ethers, whenever the existence of such isomers, esters, ethers, and salts is possible) when either substance alone, or their combined amount if both are present, is above a specified threshold, in schedule I of the Controlled Substances Act (CSA). Based on a different threshold provided by the Department of Health and Human Services (HHS) in July of 2025, DEA published a notice of intent to temporarily schedule 7-hydroxymitragynine above that lower threshold on July 7, 2026. Additionally, DEA published a temporary order placing mitragynine pseudoindoxyl without a threshold in schedule I of the CSA on August 26, 2026. On October 8, 2026, HHS sent a letter recommending that DEA place of the CSA 7-hydroxymitragynine and mitragynine pseudoindoxyl in schedule I when either substance alone, or their combined amount if both are present, is above a new specified threshold. Based on the October 8, 2026 letter, DEA is issuing this notice of intent. While the new threshold recommended by HHS would permit certain products to remain in the marketplace without being subject to schedule I controls, neither HHS nor DEA has made a finding that these substances are safe to use at below-threshold levels. When a temporary order is issued, it will impose the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances on persons who handle (manufacture, distribute, reverse distribute, import, export, engage in research, conduct instructional activities or chemical analysis with, or possess) or propose to handle 7- hydroxymitragynine and/or mitragynine pseudoindoxyl above the specified threshold. In a separate document contained in this issue of the Federal Register, DEA is withdrawing the July 7, 2026 notice of intent related to 7-hydroxymitragynine. The August 26, 2026 temporary order placing mitragynine pseudoindoxyl in schedule I of the CSA without a threshold remains in effect until either it expires or the new temporary order is published and the previous order is withdrawn, whichever occurs first.","action":"Proposed amendment; notice of intent.","agencies":[{"raw_name":"DEPARTMENT OF JUSTICE","name":"Justice Department","id":268,"url":"https://www.federalregister.gov/agencies/justice-department","json_url":"https://www.federalregister.gov/api/v1/agencies/268","parent_id":null,"slug":"justice-department"},{"raw_name":"Drug Enforcement Administration","name":"Drug Enforcement Administration","id":116,"url":"https://www.federalregister.gov/agencies/drug-enforcement-administration","json_url":"https://www.federalregister.gov/api/v1/agencies/116","parent_id":268,"slug":"drug-enforcement-administration"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/2026/10/14/2026-20943.html","cfr_references":[{"chapter":null,"citation_url":null,"part":"1308","title":21}],"citation":"91 FR 65370","comment_url":null,"comments_close_on":null,"correction_of":null,"corrections":[],"dates":"October 14, 2026.","disposition_notes":null,"docket_ids":["Docket No. DEA-1570"],"dockets":[{"supporting_documents":[{"title":"261008 ASH memo to DEA- Recommendation on 7-OH thresholding- 712892 ASH signed- UPDATED","document_id":"DEA-2026-1190-0005"},{"title":"DEA Notification to HHS NOI 7-OH MGPI_A. Cole Signed","document_id":"DEA-2026-1190-0004"},{"title":"DEA-1570 Three Factor Analysis of Specified 7-hydoxymitragynine above a specified threshold","document_id":"DEA-2026-1190-0003"},{"title":"7-OH-MG DEA-1570 HHS Letter to DEA","document_id":"DEA-2026-1190-0002"}],"agency_name":"DEA","documents":[{"comment_count":0,"comment_start_date":"2026-10-14","updated_at":"2026-10-14T10:57:32.986-04:00","comment_url":"https://www.regulations.gov/commenton/DEA-2026-1190-0006","allow_late_comments":false,"id":"DEA-2026-1190-0006","comment_end_date":null,"regulations_dot_gov_open_for_comment":false}],"supporting_documents_count":4,"id":"DEA-2026-1190","title":"Schedules of Controlled Substance: Temporary Placement of 7-Hydroxy mitragynine Above a Specified Threshold in Schedule I (DEA1570)"}],"document_number":"2026-20943","effective_on":null,"end_page":65381,"executive_order_notes":null,"executive_order_number":null,"full_text_xml_url":"https://www.federalregister.gov/documents/full_text/xml/2026/10/14/2026-20943.xml","html_url":"https://www.federalregister.gov/documents/2026/10/14/2026-20943/schedules-of-controlled-substances-temporary-placement-of-7--hydroxymitragynine-and-mitragynine","images":{},"images_metadata":{},"json_url":"https://www.federalregister.gov/api/v1/documents/2026-20943?publication_date=2026-10-14","mods_url":"https://www.govinfo.gov/metadata/granule/FR-2026-10-14/2026-20943/mods.xml","not_received_for_publication":null,"page_length":12,"page_views":{"count":5273,"last_updated":"2026-10-28 22:15:04 -0400"},"pdf_url":"https://www.govinfo.gov/content/pkg/FR-2026-10-14/pdf/2026-20943.pdf","presidential_document_number":null,"proclamation_number":null,"public_inspection_pdf_url":"https://public-inspection.federalregister.gov/2026-20943.pdf?1791561615","publication_date":"2026-10-14","raw_text_url":"https://www.federalregister.gov/documents/full_text/text/2026/10/14/2026-20943.txt","regulation_id_number_info":{},"regulation_id_numbers":[],"regulations_dot_gov_info":{"supporting_documents":[{"title":"261008 ASH memo to DEA- Recommendation on 7-OH thresholding- 712892 ASH signed- UPDATED","document_id":"DEA-2026-1190-0005"},{"title":"DEA Notification to HHS NOI 7-OH MGPI_A. Cole Signed","document_id":"DEA-2026-1190-0004"},{"title":"DEA-1570 Three Factor Analysis of Specified 7-hydoxymitragynine above a specified threshold","document_id":"DEA-2026-1190-0003"},{"title":"7-OH-MG DEA-1570 HHS Letter to DEA","document_id":"DEA-2026-1190-0002"}],"comments_count":0,"agency_id":"DEA","comments_url":"https://www.regulations.gov/docketBrowser?rpp=50&so=DESC&sb=postedDate&po=0&dct=PS&D=DEA-2026-1190","supporting_documents_count":4,"docket_id":"DEA-2026-1190","document_id":"DEA-2026-1190-0006","regulation_id_number":null,"title":"Schedules of Controlled Substance: Temporary Placement of 7-Hydroxy mitragynine Above a Specified Threshold in Schedule I (DEA1570)","checked_regulationsdotgov_at":"2026-10-15T17:55:05Z"},"regulations_dot_gov_url":null,"significant":null,"signing_date":null,"start_page":65370,"subtype":null,"title":"Schedules of Controlled Substances: Temporary Placement of 7- Hydroxymitragynine and Mitragynine Pseudoindoxyl Above a Specified Threshold in Schedule I","toc_doc":"Temporary Placement of 7-Hydroxymitragynine and Mitragynine Pseudoindoxyl Above a Specified Threshold in Schedule I","toc_subject":"Schedules of Controlled Substances","topics":["Administrative practice and procedure","Drug traffic control","Reporting and recordkeeping requirements"],"type":"Proposed Rule","volume":91}