{"abstract":"The Food and Drug Administration (FDA) is considering establishing requirements for label information about the free glutamate content of foods. The recent finding of the Federation of American Societies for Experimental Biology (FASEB) that oral ingestion of 3 or more grams (g) of monosodium glutamate (MSG) without food can cause adverse reactions in certain otherwise healthy individuals has prompted the agency to consider what action is necessary to protect consumers from inadvertently ingesting levels of MSG or other forms of free glutamate that could cause an adverse reaction. Thus, the agency seeks public comment on whether additional labeling requirements are necessary to protect glutamate-intolerant consumers from adverse reactions, and, if so, how such labeling requirements should be implemented. The agency also solicits comment on establishing formal criteria for the use of claims about the absence of MSG to ensure that labels bearing such claims are not misleading. The agency solicits comment on whether such criteria should be based on a defined threshold level of free glutamate in a finished food, on the ingredients used in the food, or both.","action":"Advance notice of proposed rulemaking.","agencies":[{"raw_name":"DEPARTMENT OF HEALTH AND HUMAN SERVICES","name":"Health and Human Services Department","id":221,"url":"https://www.federalregister.gov/agencies/health-and-human-services-department","json_url":"https://www.federalregister.gov/api/v1/agencies/221","parent_id":null,"slug":"health-and-human-services-department"}],"body_html_url":"https://www.federalregister.gov/documents/full_text/html/1996/09/12/96-23159.html","cfr_references":[{"chapter":null,"citation_url":null,"part":101,"title":21}],"citation":"61 FR 48102","comment_url":null,"comments_close_on":"1996-11-12","correction_of":null,"corrections":[],"dates":"Written comments by November 12, 1996.","disposition_notes":null,"docket_ids":["Docket No. 96N-0244"],"dockets":[],"document_number":"96-23159","effective_on":null,"end_page":48110,"executive_order_notes":null,"executive_order_number":null,"explanation":null,"full_text_xml_url":null,"html_url":"https://www.federalregister.gov/documents/1996/09/12/96-23159/food-labeling-declaration-of-free-glutamate-in-food","images":{},"images_metadata":{},"json_url":"https://www.federalregister.gov/api/v1/documents/96-23159?publication_date=1996-09-12","mods_url":"https://www.govinfo.gov/metadata/granule/FR-1996-09-12/96-23159/mods.xml","not_received_for_publication":null,"page_length":9,"page_views":{"count":238,"last_updated":"2026-04-04 18:15:03 -0400"},"pdf_url":"https://www.govinfo.gov/content/pkg/FR-1996-09-12/pdf/96-23159.pdf","presidential_document_number":null,"proclamation_number":null,"public_inspection_pdf_url":null,"publication_date":"1996-09-12","raw_text_url":"https://www.federalregister.gov/documents/full_text/text/1996/09/12/96-23159.txt","regulation_id_number_info":{},"regulation_id_numbers":[],"regulations_dot_gov_info":{"checked_regulationsdotgov_at":"2011-09-21T08:47:36Z"},"regulations_dot_gov_url":null,"significant":null,"signing_date":null,"start_page":48102,"subtype":null,"title":"Food Labeling; Declaration of Free Glutamate in Food","toc_doc":null,"toc_subject":null,"topics":[],"type":"Proposed Rule","volume":61}