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Notice

Proposed Substances To Be Evaluated for Set 23 Toxicological Profiles

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Information about this document as published in the Federal Register.

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Start Preamble

AGENCY:

Agency for Toxic Substances and Disease Registry (ATSDR), Department of Health and Human Services (HHS).

ACTION:

Request for comments on the proposed substances to be evaluated for Set 23 toxicological profiles.

SUMMARY:

This notice announces the list of proposed substances that will be evaluated for CERCLA Set 23 toxicological profile development. ATSDR's Division of Toxicology and Environmental Medicine is soliciting public nominations from the list of proposed substances to be evaluated for toxicological profile development. ATSDR also will consider the evaluation of any additional substances that may have public health implications.

DATES:

Nominations must be submitted by December 24th, 2008.

ADDRESSES:

Nominations may be submitted electronically, by mail, or by facsimile. Refer to the section Submission of Nominations (below) for specific addresses and/or the facsimile number.

Start Further Info

FOR FURTHER INFORMATION:

Contact Commander Jessilynn B. Taylor, Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, Mailstop F-32, 1600 Clifton Road, NE., Atlanta, Georgia 30333, telephone (770) 488-3313.

End Further Info End Preamble Start Supplemental Information

SUPPLEMENTARY INFORMATION:

The Superfund Amendments and Reauthorization Act of 1986 (SARA) [42 U.S.C. 9601 et seq.] amended the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA or Superfund) [42 U.S.C. 9601 et seq.] by establishing certain requirements for ATSDR and the U.S. Environmental Protection Agency (EPA) with regard to hazardous substances that are most commonly found at facilities on the CERCLA National Priorities List (NPL). Among these statutory requirements is a mandate for the Administrator of ATSDR to prepare toxicological profiles for each substance included on the Priority List of Hazardous Substances. This list has identified 275 hazardous substances that ATSDR and EPA determined pose the most significant potential threat to human health. The availability of the revised list of the 275 priority substances was announced in the Federal Register on March 6, 2008 (73 FR 12178). For previous versions of the list of substances, see Federal Register notices dated April 17, 1987 (52 FR 12866); October 20, 1988 (53 FR 41280); October 26, 1989 (54 FR 43619); October 17, 1990 (55 FR 42067); October 17, 1991 (56 FR 52166); October 28, 1992 (57 FR 48801); February 28, 1994 (59 FR 9486); April 29, 1996 (61 FR 18744; November 17, 1997 (62 FR 61332); October 21, 1999 (64 FR 56792); October 25, 2001 (66 FR 54014); November 7, 2003 (68 FR 63098); and December 7, 2005 (70 FR 70284).

Proposed Substances To Be Evaluated for Set 23 Toxicological Profiles

Each year, ATSDR develops a list of priority substances that will be evaluated for toxicological profile development. This list was compiled, on the basis of ATSDR's Priority List of Hazardous Substances, with consideration of the amount of relevance of newly published scientific Start Printed Page 73330literature. The following 80 substances will be evaluated:

NameCAS
1MERCURY007439-97-6
METHYLMERCURY022967-92-6
MERCURIC CHLORIDE007487-94-7
2POLYCHLORINATED BIPHENYLS001336-36-3
AROCLOR 1254011097-69-1
AROCLOR 1260011096-82-5
AROCLOR 1248012672-29-6
AROCLOR 1242053469-21-9
AROCLOR012767-79-2
AROCLOR 1221011104-28-2
AROCLOR 1016012674-11-2
AROCLOR 1232011141-16-5
AROCLOR 1240071328-89-7
TETRACHLOROBIPHENYL026914-33-0
3POLYCYCLIC AROMATIC HYDROCARBONS130498-29-2
BENZO(A)PYRENE000050-32-8
BENZO(B)FLUORANTHENE000205-99-2
DIBENZO(A,H)ANTHRACENE000053-70-3
BENZO(A)ANTHRACENE000056-55-3
BENZO(K)FLUORANTHENE000207-08-9
BENZOFLUORANTHENE056832-73-6
FLUORANTHENE000206-44-0
CHRYSENE000218-01-9
ACENAPHTHENE000083-32-9
INDENO(1,2,3-CD)PYRENE000193-39-5
BENZOPYRENE073467-76-2
PHENANTHRENE000085-01-8
PYRENE000129-00-0
FLUORENE000086-73-7
ANTHRACENE000120-12-7
BENZO(A)FLUORANTHENE000203-33-8
BENZO(GHI)PERYLENE000191-24-2
ACENAPHTHYLENE000208-96-8
BENZO(J)FLUORANTHENE000205-82-3
BENZO(E)PYRENE000192-97-2
BENZOPERYLENE011057-45-7
BENZO(B)ANTHRACENE000092-24-0
DIBENZ(A,J)ANTHRACENE000224-41-9
BENZO(GHI)FLUORANTHENE000203-12-3
1-METHYLPYRENE002381-21-7
4CHLOROFORM000067-66-3
5DDT, P,P′-000050-29-3
DDE, P,P′-000072-55-9
DDD, P,P′-000072-54-8
DDT, O,P′-000789-02-6
DDD, O,P′-000053-19-0
DDE, O,P′-003424-82-6
6TRICHLOROETHYLENE000079-01-6
7DIELDRIN000060-57-1
ALDRIN000309-00-2
8CHLORDANE000057-74-9
CIS-CHLORDANE005103-71-9
TRANS-CHLORDANE005103-74-2
OXYCHLORDANE027304-13-8
GAMMA-CHLORDENE056641-38-4
CHLORDANE, TECHNICAL012789-03-6
ALPHA-CHLORDENE056534-02-2
NONACHLOR, TRANS-039765-80-5
NONACHLOR, CIS-005103-73-1
CHLORDENE003734-48-3
9HEXACHLOROBUTADIENE000087-68-3
10COAL TAR CREOSOTE008001-58-9
COAL TARS008007-45-2
COAL TAR PITCH065996-93-2
11BENZIDINE000092-87-5
12TOXAPHENE008001-35-2
13TETRACHLOROETHYLENE000127-18-4
141,2-DIBROMOETHANE000106-93-4
15DISULFOTON000298-04-4
163,3′-DICHLOROBENZIDINE000091-94-1
17ENDRIN000072-20-8
Start Printed Page 73331
ENDRIN KETONE053494-70-5
ENDRIN ALDEHYDE007421-93-4
18BERYLLIUM007440-41-7
191,2-DIBROMO-3-CHLOROPROPANE000096-12-8
DIBROMOCHLOROPROPANE067708-83-2
20PENTACHLOROPHENOL000087-86-5
21DI-N-BUTYL PHTHALATE000084-74-2
22ENDOSULFAN000115-29-7
ENDOSULFAN SULFATE001031-07-8
ENDOSULFAN, ALPHA000959-98-8
ENDOSULFAN, BETA033213-65-9
23METHOXYCHLOR000072-43-5
24METHANE000074-82-8
25TOLUENE000108-88-3
262-HEXANONE000591-78-6
272,3,7,8-TETRACHLORODIBENZO-P-DIOXIN001746-01-6
HEXACHLORODIBENZO-P-DIOXIN034465-46-8
HEPTACHLORODIBENZO-P-DIOXIN037871-00-4
TETRACHLORODIBENZO-P-DIOXIN041903-57-5
PENTACHLORODIBENZO-P-DIOXIN036088-22-9
1,2,3,4,6,7,8-HEPTACHLORODIBENZO-P-DIOXIN035822-46-9
OCTACHLORODIBENZO-P-DIOXIN003268-87-9
1,2,3,6,7,8-HEXACHLORODIBENZO-P-DIOXIN057653-85-7
1,2,3,4,7,8-HEXACHLORODIBENZO-P-DIOXIN039227-28-6
1,2,3,7,8,9-HEXACHLORODIBENZO-P-DIOXIN019408-74-3
1,2,3,7,8-PENTACHLORODIBENZO-P-DIOXIN040321-76-4
28DI(2-ETHYLHEXYL)PHTHALATE000117-81-7
291,1-DICHLOROETHENE000075-35-4
30METHYLENE CHLORIDE000075-09-2
31BROMODICHLOROETHANE000683-53-4
321,2-DICHLOROETHANE000107-06-2
332,4,6-TRICHLOROPHENOL000088-06-2
TETRACHLOROPHENOL025167-83-3
2,4-DICHLOROPHENOL000120-83-2
2,4,5-TRICHLOROPHENOL000095-95-4
2-CHLOROPHENOL000095-57-8
2,3,4,5-TETRACHLOROPHENOL004901-51-3
2,3,5,6-TETRACHLOROPHENOL000935-95-5
2,3,4,6-TETRACHLOROPHENOL000058-90-2
4-CHLOROPHENOL000106-48-9
CHLOROPHENOL025167-80-0
342,4-DINITROPHENOL000051-28-5
35BIS(2-CHLOROETHYL) ETHER000111-44-4
36ASBESTOS001332-21-4
CHRYSOTILE ASBESTOS012001-29-5
AMOSITE ASBESTOS012172-73-5
37HEXACHLOROBENZENE000118-74-1
382,4-DINITROTOLUENE000121-14-2
DINITROTOLUENE025321-14-6
2,6-DINITROTOLUENE000606-20-2
39RADIUM-226013982-63-3
RADIUM007440-14-4
RADIUM-228015262-20-1
RADIUM-224013233-32-4
40ETHION000563-12-2
41THORIUM007440-29-1
THORIUM-230014269-63-7
THORIUM-228014274-82-9
424,6-DINITRO-O-CRESOL000534-52-1
42CHLOROBENZENE000108-90-7
44N-NITROSODI-N-PROPYLAMINE000621-64-7
451,2,3-TRICHLOROBENZENE000087-61-6
46POLONIUM-210013981-52-7
47CHLORPYRIFOS002921-88-2
48NEPTUNIUM-237013994-20-2
49CHLORDECONE000143-50-0
MIREX002385-85-5
50S,S,S-TRIBUTYL PHOSPHOROTRITHIOATE000078-48-8
51BROMINE007726-95-6
52DICOFOL000115-32-2
53PARATHION000056-38-2
54SELENIUM007782-49-2
55TRICHLOROFLUOROETHANE027154-33-2
56TRIFLURALIN001582-09-8
Start Printed Page 73332
574,4′-METHYLENEBIS(2-CHLOROANILINE)000101-14-4
58PENTACHLOROBENZENE000608-93-5
591,3-BUTADIENE000106-99-0
601,1-DICHLOROETHANE000075-34-3
611,2,3,4,6,7,8,9-OCTACHLORODIBENZOFURAN039001-02-0
HEPTACHLORODIBENZOFURAN038998-75-3
2,3,4,7,8-PENTACHLORODIBENZOFURAN057117-31-4
HEXACHLORODIBENZOFURAN055684-94-1
PENTACHLORODIBENZOFURAN030402-15-4
2,3,7,8-TETRACHLORODIBENZOFURAN051207-31-9
DIBENZOFURANS, CHLORINATED042934-53-2
1,2,3,4,6,7,8-HEPTACHLORODIBENZOFURAN067562-39-4
1,2,3,7,8,9-HEXACHLORODIBENZOFURAN072918-21-9
TETRACHLORODIBENZOFURAN030402-14-3
1,2,3,6,7,8-HEXACHLORODIBENZOFURAN057117-44-9
1,2,3,4,7,8-HEXACHLORODIBENZOFURAN070648-26-9
2,3,4,6,7,8-HEXACHLORODIBENZOFURAN060851-34-5
1,2,3,7,8-PENTACHLORODIBENZOFURAN057117-41-6
1,2,3,4,7,8,9-HEPTACHLORODIBENZOFURAN055673-89-7
621,1,2-TRICHLOROETHANE000079-00-5
63HEXACHLOROCYCLOPENTADIENE000077-47-4
641,2-DIPHENYLHYDRAZINE000122-66-7
651,2-DICHLOROETHENE, TRANS-000156-60-5
1,2-DICHLOROETHYLENE000540-59-0
1,2-DICHLOROETHENE, CIS-000156-59-2
66CARBON DISULFIDE000075-15-0
67PALLADIUM007440-05-3
68CHLOROETHANE000075-00-3
98ACETONE000067-64-1
70DIBENZOFURAN000132-64-9
712,4-DIMETHYLPHENOL000105-67-9
72CARBON MONOXIDE000630-08-0
73CHLOROMETHANE000074-87-3
74BUTYL BENZYL PHTHALATE000085-68-7
75VANADIUM007440-62-2
76N-NITROSODIMETHYLAMINE000062-75-9
771,2,4-TRICHLOROBENZENE000120-82-1
78N-NITROSODIPHENYLAMINE000086-30-6
792-BUTANONE000078-93-3
80FLUORINE007782-41-4
HYDROGEN FLUORIDE007664-39-3
FLUORIDE ION016984-48-8

Submission of Nominations for the Evaluation Set 23 Proposed Substances: Today's notice also invites voluntary public nominations for substances not listed in this notice. Nominations are most useful if they include the full name, title, affiliation, e-mail address and telephone number of the nominator.

ATSDR will evaluate all data and information associated with nominated substances and will determine the final list of substances that will be chosen for toxicological profile development. Substances will be chosen according to ATSDR's specific guidelines for selection, found in the Selection Criteria announced in the Federal Register on May 7th, 1993 (87 FR 27288).

Please submit nominations by one of the following methods:

  • E-mail jxt1@cdc.gov.
  • Fax 770.488.4178.
  • Mail CDR Jessilynn Taylor, 1600 Clifton Rd, NE., MS F32, Atlanta, GA 30333.

Please ensure that your comments are submitted within the specified nomination period. Nominations received after the closing date will be marked as late and may be considered only if time permits.

Start Signature

Dated: November 26, 2008.

Ken Rose,

Director, Office of Policy, Planning, and Evaluation National Center for Environmental Health/Agency for Toxic Substances and Disease Registry.

End Signature End Supplemental Information

[FR Doc. E8-28551 Filed 12-1-08; 8:45 am]

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