This notice summarizes the agency's actions to obtain additional scientific input and announces the agency's decision with respect to the space density of the primary living space of captive research chimpanzees owned or supported by the National Institutes of Health (NIH) or used in NIH-supported research. The NIH has prepared procedural guidance and technical assistance for researchers, facility staff, and agency staff to ensure proper implementation of the agency's decisions. Investigators should follow guidance (see NOT-OD-14-024 at http://www.grants.nih.gov/grants/guide/notice-files/NOT-OD-14-024.html) regarding the submission of applications, proposals, or protocols for research involving chimpanzees.
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In February 2012, the NIH charged a working group of the Council of Councils, a federal advisory committee, to provide advice on implementing recommendations made by the Institute of Medicine (IOM) Committee on the Use of Chimpanzees in Biomedical and Behavioral Research in its 2011 report, Chimpanzees in Biomedical and Behavioral Research: Assessing the Necessity. On January 22, 2013, the NIH Council of Councils (Council) accepted recommendations presented by the Working Group on the Use of Chimpanzees in NIH-Supported Research in its report (see http://dpcpsi.nih.gov/sites/default/files/FNL_Report_WG_Chimpanzees_0.pdf) and provided these recommendations to the NIH. The NIH subsequently issued a request for information, http://www.gpo.gov/fdsys/pkg/FR-2013-02-05/html/2013-02507.htm, to obtain broad public input on the 28 Council recommendations the NIH considered as it determined how to implement the IOM Committee's recommendations.
In June 2013, the NIH announced its decisions with respect to the Council of Councils' recommendations; see http://dpcpsi.nih.gov/sites/default/files/NIH_response_to_Council_of_Councils_recommendations_62513.pdf. The agency accepted 27 of the 28 Council recommendations. Included in these were 10 recommendations describing the characteristics of a captive environment that allow for and promote a full range of behaviors that are natural for chimpanzees—or ethologically appropriate environments (EAE). The NIH accepted 9 of the 10 Council's recommendations on EAE, including recommendations on enclosure height, foraging and diet, nesting materials, enrichment, a staff to chimpanzee ratio, staff training, and recordkeeping. The NIH did not accept Recommendation EA2—“The density of the primary living space of chimpanzees should be at least 1,000 ft2 (93 m2) per individual. Therefore, the minimum outdoor enclosure size for a group of 7 animals should be 7,000 ft2 (651 m2).”—based on comments received from the public. Because of concerns about the scientific basis for this recommendation and the expected costs of implementing it, the agency further reviewed the space density requirements with respect to the promotion of species-appropriate behavior.
While a large number of commenters who addressed Recommendation EA2 supported the recommendation, some commenters emphasized the amount of space recommended is the minimum needed and larger enclosures that more closely replicate the amount of space available to chimpanzees in the wild are Start Printed Page 19918preferable. Other commenters encouraged the NIH to identify data in the scientific literature on the appropriate area for chimpanzee housing, while others argued that the recommended 1,000 ft2 area is arbitrary and unnecessary, is not based on or is contrary to the published literature, and does not accurately reflect the opinions of some of the experts consulted by the Council Working Group. Several commenters noted that certain publications cited by the Council Working Group pertain to gorillas or to spaces smaller than 1,000 ft2. In the absence of sufficient supporting scientific evidence, these commenters did not believe that larger housing environments would improve chimpanzee well-being. Others suggested that rather than establishing minimum space requirements, the NIH should consider the complexity and quality of the environment, including the opportunity for chimpanzees to take temporary refuge from other members of their group.
The agency was concerned about the lack of scientific consensus and especially whether the published literature supports the Council's recommendation of providing 1,000 ft2 of living space per chimpanzee. Given that concern, the NIH sought additional input on an individual basis on the space density needs of captive research chimpanzees from experts with extensive experience in veterinary medicine, behavioral management of primates, renovation of chimpanzee housing and research facilities, primate facility management, and behavioral primatology (https://dpcpsi.nih.gov/sites/default/files/Space-Density-EAE-List-of-Experts.pdf).
Independent of seeking expert input, the NIH commissioned a literature review, https://dpcpsi.nih.gov/sites/default/files/ElseLitReviewFinal-110713.pdf, focused on the space density needed to support an ethologically appropriate physical and social environment for captive chimpanzees in a research environment. The literature review was prepared by a pre-eminent veterinary primatologist. That individual was also asked to identify, review, and summarize relevant parts of U.S. regulations and other requirements.
The relevant animal welfare/regulatory requirements and guidance pertaining to the space density needs of captive research chimpanzees are summarized in the literature review (pages 2-4). The Animal Welfare Act Regulations, http://www.gpo.gov/fdsys/pkg/CFR-2013-title9-vol1/xml/CFR-2013-title9-vol1-chapI-subchapA.xml, list the minimum space requirements for the nonhuman primate (NHP) weight category that includes chimpanzees as 25 ft2 for floor area per animal, and 84 inches for enclosure height. 9 CFR part 3.80. The regulations note that many of the NHP requirements are generic and the conditions appropriate for one species do not necessarily apply to another. Per the regulations, the “minimum specifications must be applied in accordance with the customary and generally accepted professional and husbandry practices considered appropriate for each species, and necessary to promote their psychological well-being.” 9 CFR part 3, n. 2. The Chimpanzee Health Improvement, Maintenance, and Protection (CHIMP) Act (Pub. L. 106-551; http://www.gpo.gov/fdsys/pkg/PLAW-106publ551/pdf/PLAW-106publ551.pdf) directs the Secretary of Health and Human Services to develop by regulation standards for operating the federally supported sanctuary system to provide for the permanent retirement of chimpanzees that are no longer required for research. The regulations (42 CFR part 9) that implement the CHIMP Act do not specify enclosure size but stipulate that the size of the sanctuary facilities must be in accordance with the recommendations of The Guide for the Care and Use of Laboratory Animals, which align with the minimum space requirements of the Animal Welfare Act Regulations. The Association of Zoos and Aquariums and the Global Federation of Animal Sanctuaries recommend space densities that differ from each other and from the one in Recommendation EA2.
The remainder of this document summarizes the literature review and expert input.
The literature review revealed very limited empirical data is available on which to base a determination of the minimum space density necessary to provide an EAE for captive chimpanzees, and no quantitative data was found to support the figure of 1,000 ft2/individual chimpanzee. Relatively few investigators have reported data that measure chimpanzee well-being using space density as a variable, with Ross and his colleagues, who have been studying enclosure design in zoos for more than 10 years, being one of the notable exceptions. Ross et al. (2011a) postulated that once the “minimal size threshold is crossed” (as they speculated could possibly be the case with their Great Ape House facility—space density 12.2 m2/individual) they “would then expect diminishing behavioral and welfare benefits with further increases.” Wilson (1982) made a similar observation, noting that increasing space beyond that required may have little effect on activity.
The literature review noted there was general consensus among essentially all investigators as to the importance of vertical space, climbable space, three-dimensional space, gross usable space, and other similar enclosure parameters, and the necessity for significant environmental complexity within the enclosure. The general impression gained from the literature review is that these parameters share equal importance with space density when captive chimpanzee well-being is considered. The difficulty is the lack of a simple, replicable way to measure them.
There was also general consensus that chimpanzees neither like nor use open spaces and in most situations they use only a small proportion of their enclosure space. This is consistent with conclusions of many investigators that the overall quantity of cage space alone has limited value when designing an enclosure to maximize the well-being of primates because the usefulness of space depends upon its quality rather than quantity (Reinhardt et al., 1996; Wilson, 1982; Stoinski et al., 2001; Ross et al., 2011a) and, having no stimulatory value, space alone does not enhance an animal's environment (Reinhardt et al., 1996).
The literature review also questioned whether the full range of wild chimpanzee behavior, particularly some aspects of fission-fusion, are applicable to captive situations, and whether some behaviors, such as traveling long distances in search for food or patrolling the borders of their territories, may in fact not be necessary for captive group well-being, nor desirable for group stability.
Independent of the literature review, the NIH sought input from individuals with extensive expertise in veterinary medicine; behavioral management of primates; renovation of chimpanzee housing and research facilities; primate and chimpanzee facility management; and behavioral primatology. The NIH contacted each expert individually and sought input on the question of space density needs of captive research chimpanzees. The calls with the individual experts preceded the preparation of the literature review to ensure that one process did not influence the other.
The views of the experts were very similar to the literature review. Each of Start Printed Page 19919the experts emphasized the critical importance of environmental complexity rather than focusing only on the square footage of living space per chimpanzee as a means of ensuring species-typical behavior. The experts also noted that different animals/groups within a colony would require different stimuli to exhibit species-typical behavior. The experts reiterated the difficulty in identifying square footage requirements, including lack of published literature in this area. Based on their experience in behavioral management of chimpanzees, as veterinarians and by directing and operating facilities for captive research chimpanzees, several of the experts recommended minimum space needed to promote species-typical behavior. The recommendations ranged from 150-500 ft2 of living space per animal.
The literature review demonstrated there is little published literature containing quantitative scientific data that can be used to support a determination of the minimum space density (horizontal surface area per animal) needed to support an EAE for captive chimpanzees. Furthermore, other aspects of enclosure design, such as complexity and vertical height, are considered by many experts to be more important than space density with respect to chimpanzee well-being and the promotion of species-specific behavior.
Based on both the literature review and recommendations from individual experts, it is clear that published guidelines for minimum living space area for captive research chimpanzees are variable. Encouraging species-typical behavior among chimpanzees does not simply result from providing a minimum square footage of living space per animal. Rather, the characteristics (complexity) of the space as well as enrichment opportunities have a significant effect on promoting species-typical behavior. The environment should take into account the individual chimpanzees' and colony characteristics, including social, health, age, and biological factors.
Based on the recommendation from the Council of Councils, the information contained in the literature review, and additional input from scientific, veterinary, and facility experts, the NIH has decided that the density of the primary living space of chimpanzees should be at least 250 ft2 per chimpanzee. This decision supplements the agency decisions on the nine EAE recommendations made by the Council of Councils (see EA1, EA3-10 at http://dpcpsi.nih.gov/sites/default/files/NIH_response_to_Council_of_Councils_recommendations_62513.pdf). The NIH expects the facilities it supports to monitor the chimpanzees for species-typical behavior.
The NIH has prepared procedural guidance and technical assistance for researchers, facility staff, and agency staff to ensure proper implementation of the agency's decisions. Investigators should follow guidance (see NOT-OD-14-024 at http://www.grants.nih.gov/grants/guide/notice-files/NOT-OD-14-024.html) regarding the submission of applications, proposals, or protocols for research involving chimpanzees.
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Dated: February 25, 2014.
Francis S. Collins,
Director, National Institutes of Health.
[FR Doc. 2014-08062 Filed 4-9-14; 8:45 am]
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