SUPPLEMENTARY INFORMATION:

I. General Information

A. Does this action apply to me?

This notice is directed to the public in general and may be of interest to a wide range of stakeholders including environmental, human health, farm workers, and agricultural advocates; the chemical industry; pesticide users; and members of the public interested in the sale, distribution, or use of pesticides. Since others may also be interested, the Agency has not attempted to describe all the specific entities that may be affected by this action.

B. What should I consider as I prepare my comments for EPA?

1. Submitting CBI

Do not submit CBI to EPA through https://www.regulations.gov or email. If you wish to include CBI in your comment, please follow the applicable instructions at https://www.epa.gov/​dockets/​commenting-epa-dockets#rules and clearly mark the information that you claim to be CBI. Information so marked will not be disclosed except in accordance with procedures set forth in 40 CFR parts 2 and 703, as applicable.

2. Tips for Preparing Your Comments

When preparing and submitting your comments, see the commenting tips at https://www.epa.gov/​dockets/​commenting-epa-dockets.

II. What action is the Agency taking?

The EPA's Office of Pesticide Programs (OPP) is currently reevaluating glyphosate as part of registration review, which is required by law every 15 years to ensure that pesticide products on the market continue to meet the statutory standard for registration as science evolves and new information becomes available. In addition to guideline studies, required under 40 CFR part 158, and non-guideline studies that are submitted to the EPA to support pesticide registration, EPA searches for relevant studies published in peer-reviewed scientific journals in the open literature. In the case of glyphosate, there are a large number of independent studies available in the open literature. Since the initiation of Registration Review, EPA has performed multiple searches of open literature to identify, screen, and evaluate potentially relevant studies using systematic review approaches consistent with Executive Order 14303, Restoring Gold Standard Science and Gold Standard Science (90 FR 22601; May 23, 2025) objectives. In addition, EPA has received additional studies to consider during public comment periods in the Registration Review ( printed page 54871) process. To supplement the previous human health open literature searches, a new systematic open literature search was performed to identify potentially relevant studies published more recently to inform human health risk assessment. EPA's open literature search document summarizes prior search efforts, details the search strategy, including search terms, databases, and inclusion/exclusion criteria, and provides an explanation of the multistep screening and evaluation process used to determine study quality and relevance for inclusion in human health risk assessment. Studies identified across all search efforts, including those submitted through public comment, are listed in an accompanying spreadsheet.

The objective of this public comment period is to solicit public input to identify and submit any relevant, peer-reviewed studies that are not included in this list of studies for consideration as part of the upcoming updated human health risk assessment, which is targeted for completion in late 2026 and subsequent release for public comment. For the Agency to consider any submitted data or studies, there must be open access to the article or study report and its supporting data. When providing input to EPA, commenters should include the full citation reference to the article that includes the study author(s), date of publication, journal title, and the article title.

(Authority: 7 U.S.C. 136 et seq.)