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Notice

Proposed Substances To Be Evaluated for Set 24 Toxicological Profiles

Action

Request For Comments On The Proposed Substances To Be Evaluated For Set 24 Toxicological Profiles.

Summary

This notice announces the list of proposed substances that will be evaluated for Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) Set 24 toxicological profile development. ATSDR's Division of Toxicology and Environmental Medicine is soliciting public comments on the list of proposed substances to be evaluated for toxicological profile development. ATSDR also will consider the nomination of any additional, substances, not on this list, that may have public health implications.

 

Table of Contents Back to Top

DATES: Back to Top

Nominations must be submitted within 30 days of the publication of this notice.

ADDRESSES: Back to Top

Nominations may be submitted electronically. Refer to the section Submission of Nominations (following) for the specific address.

FOR FURTHER INFORMATION CONTACT: Back to Top

For further information, contact: Commander Jessilynn B. Taylor, Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, 1600 Clifton Road, F-62, Atlanta, GA, 30333; telephone: (770) 488-3313; or e-mail: jbtaylor@cdc.gov.

SUPPLEMENTARY INFORMATION: Back to Top

The Superfund Amendments and Reauthorization Act of 1986 (SARA) [42 U.S.C. 9601 et seq.] amended the CERCLA (or Superfund) [42 U.S.C. 9601 et seq.] by establishing certain requirements for ATSDR and the U.S. Environmental Protection Agency (EPA) with regard to hazardous substances most commonly found at facilities on the CERCLA NPL. Among these statutory requirements is a mandate for the Administrator of ATSDR to prepare toxicological profiles for each substance included on the Priority List of Hazardous Substances. This identifies 275 hazardous substances that ATSDR and EPA have determined pose the most significant potential threat to human health (http://www.atsdr.cdc.gov/cercla/07list.html). The availability of the revised list of the 275 priority substances was announced in the Federal Register on March 6, 2008 (73 FR 12178). For prior versions of the list of substances, see Federal Register notices dated April 17, 1987 (52 FR 12866); October 20, 1988 (53 FR 41280); October 26, 1989 (54 FR 43619); October 17, 1990 (55 FR 42067); October 17, 1991 (56 FR 52166); October 28, 1992 (57 FR 48801); February 28, 1994 (59 FR 9486); April 29, 1996 (61 FR 18744; November 17, 1997 (62 FR 61332); October 21, 1999 (64 FR 56792); October 25, 2001 (66 FR 54014); and November 7, 2003 (68 FR 63098), December 7, 2005 (70 FR 72840).

Proposed Substances To Be Evaluated for Set 24 Toxicological Profiles Back to Top

Each year, ATSDR develops a list of substances to be considered for toxicological profile development. This list is compiled from ATSDR's Priority List of Hazardous Substances and from previously nominated substances of public health concern. The following list of 240 proposed substances will be considered for Set 24 Toxicological Profile development.

Substances CAS Nos.
1 METHANE 000074-82-8
2 BROMODICHLOROETHANE 000683-53-4
3 1,2,3-TRICHLOROBENZENE 000087-61-6
4 POLONIUM-210 013981-52-7
5 LEAD-210 014255-04-0
6 NEPTUNIUM-237 013994-20-2
7 S,S,S-TRIBUTYL PHOSPHOROTRITHIOATE 000078-48-8
8 BROMINE 007726-95-6
9 DICOLFOL 000115-32-2
10 PARATHIION 000056-38-2
11 TRICHLOROFLUOROETHANE 027154-33-2
12 TRIFLURALIN 000152-09-8
13 PENTACHLOROBENZENE 000608-93-5
14 TRICHLOROETHANE 025323-89-1
15 PALLADIUM 007440-05-3
16 DIBENZOFURAN 000132-64-9
17 2,4-DIMETHYLPHENOL 000105-67-9
18 TETRACHLOROETHANE 025322-20-7
19 BIS(2-METHOXYETHYL)PHTHALATE 034006-76-3
20 BUTYL BENZYL PHTHALATE 000085-68-7
21 1,2,4-TRICHLOROBENZENE 000120-82-1
22 NITRITE 014797-65-0
23 NITRATE 014797-55-8
24 POTASSIUM-40 013966-00-2
25 THORIUM-227 015623-47-9
26 PHORATE 000298-02-2
27 DIMETHOATE 000060-51-5
28 ACTINIUM-227 014952-40-0
29 STROBANE 008001-50-1
30 4-AMINOBIPHENYL 000092-67-1
31 ARSINE 007784-42-1
32 NALED 000300-76-5
33 ETHOPROP 013194-48-4
34 CARBOPHENOTHION 000786-19-6
35 2,4-D ACID 000094-75-7
36 DIURON 000330-54-1
37 BUTYLATE 002008-41-5
38 DIMETHYL FORMAMIDE 000068-12-2
39 DICHLOROBENZENE 025321-22-6
40 ETHYL ETHER 000060-29-7
41 DICHLOROETHANE 001300-21-6
42 PHOSPHINE 007803-51-2
43 TRICHLOROBENZENE 012002-48-1
44 PENTAERYTHRITOL TETRANITRATE 000078-11-5
45 BIS(2-ETHYLHEXYL)ADIPATE 000103-23-1
46 CARBAZOLE 000086-74-8
47 METHYL ISOBUTYL KETONE 000108-10-1
48 CARBARYL 000063-25-2
49 MERCURY 007439-97-6
50 METHYLMERCURY 022967-92-6
51 MERCURIC CHLORIDE 007487-94-7
52 POLYCHLORINATED BIPHENYLS 001336-36-3
53 AROCLOR 1254 011097-69-1
54 AROCLOR 1260 011096-82-5
55 AROCLOR 1248 012672-29-6
56 AROCLOR 1242 053469-21-9
57 AROCLOR 012767-79-2
58 AROCLOR 1221 011104-28-2
59 AROCLOR 1016 012674-11-2
60 AROCLOR 1232 011141-16-5
61 AROCLOR 1240 071328-89-7
62 TETRACHLOROBIPHENYL 026914-33-0
63 POLYCYCLIC AROMATIC HYDROCARBONS 130498-29-2
64 BENZO(A)PYRENE 000050-32-8
65 BENZO(B)FLUORANTHENE 000205-99-2
66 DIBENZO(A,H)ANTHRACENE 000053-70-3
67 BENZO(A)ANTHRACENE 000056-55-3
68 BENZO(K)FLUORANTHENE 000207-08-9
69 BENZOFLUORANTHENE 056832-73-6
70 FLUORANTHENE 000206-44-0
71 CHRYSENE 000218-01-9
72 ACENAPHTHENE 000083-32-9
73 INDENO(1,2,3-CD)PYRENE 000193-39-5
74 BENZOPYRENE 073467-76-2
75 PHENANTHRENE 000085-01-8
76 PYRENE 000129-00-0
77 FLUORENE 000086-73-7
78 ANTHRACENE 000120-12-7
79 BENZO(A)FLUORANTHENE 000203-33-8
80 BENZO(GHI)PERYLENE 000191-24-2
81 ACENAPHTHYLENE 000208-96-8
82 BENZO(J)FLUORANTHENE 000205-82-3
83 BENZO(E)PYRENE 000192-97-2
84 BENZOPERYLENE 011057-45-7
85 BENZO(B)ANTHRACENE 000092-24-0
86 DIBENZ(A,J)ANTHRACENE 000224-41-9
87 BENZO(GHI)FLUORANTHENE 000203-12-3
88 1-METHYLPYRENE 002381-21-7
89 CHLOROFORM 000067-66-3
90 DDT, P,P′- 000050-29-3
91 DDE, P,P′- 000072-55-9
92 DDD, P,P′- 000072-54-8
93 DDT, O,P′- 000789-02-6
94 DDD, O,P′- 000053-19-0
95 DDE, O,P′- 003424-82-6
96 TRICHLOROETHYLENE 000079-01-6
97 DIELDRIN 000060-57-1
98 ALDRIN 000309-00-2
99 CHLORDANE 000057-74-9
100 CIS-CHLORDANE 005103-71-9
101 TRANS-CHLORDANE 005103-74-2
102 OXYCHLORDANE 027304-13-8
103 GAMMA-CHLORDENE 056641-38-4
104 CHLORDANE, TECHNICAL 012789-03-6
105 ALPHA-CHLORDENE 056534-02-2
106 NONACHLOR, TRANS- 039765-80-5
107 NONACHLOR, CIS- 005103-73-1
108 CHLORDENE 003734-48-3
109 HEXACHLOROBUTADIENE 000087-68-3
110 COAL TAR CREOSOTE 008001-58-9
111 COAL TARS 008007-45-2
112 DDD, P,P′- 000072-54-8
113 COAL TAR PITCH 065996-93-2
114 BENZIDINE 000092-87-5
115 TOXAPHENE 008001-35-2
116 TETRACHLOROETHYLENE 000127-18-4
117 1,2-DIBROMOETHANE 000106-93-4
118 DISULFOTON 000298-04-4
119 3,3′-DICHLOROBENZIDINE 000091-94-1
120 ENDRIN 000072-20-8
121 ENDRIN KETONE 053494-70-5
122 ENDRIN ALDEHYDE 007421-93-4
123 BERYLLIUM 007440-41-7
124 1,2-DIBROMO-3-CHLOROPROPANE 000096-12-8
125 DIBROMOCHLOROPROPANE 067708-83-2
126 PENTACHLOROPHENOL 000087-86-5
127 DI-N-BUTYL PHTHALATE 000084-74-2
128 ENDOSULFAN 000115-29-7
129 ENDOSULFAN SULFATE 001031-07-8
130 ENDOSULFAN, ALPHA 000959-98-8
131 ENDOSULFAN, BETA 033213-65-9
132 METHOXYCHLOR 000072-43-5
133 METHANE 000074-82-8
134 TOLUENE 000108-88-3
135 2-HEXANONE 000591-78-6
136 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN 001746-01-6
137 HEXACHLORODIBENZO-P-DIOXIN 034465-46-8
138 HEPTACHLORODIBENZO-P-DIOXIN 037871-00-4
139 TETRACHLORODIBENZO-P-DIOXIN 041903-57-5
140 PENTACHLORODIBENZO-P-DIOXIN 036088-22-9
141 1,2,3,4,6,7,8-HEPTACHLORODIBENZO-P-DIOXIN 035822-46-9
142 OCTACHLORODIBENZO-P-DIOXIN 003268-87-9
143 1,2,3,6,7,8-HEXACHLORODIBENZO-P-DIOXIN 057653-85-7
144 1,2,3,4,7,8-HEXACHLORODIBENZO-P-DIOXIN 039227-28-6
145 1,2,3,7,8,9-HEXACHLORODIBENZO-P-DIOXIN 019408-74-3
146 1,2,3,7,8-PENTACHLORODIBENZO-P-DIOXIN 040321-76-4
147 DI(2-ETHYLHEXYL)PHTHALATE 000117-81-7
148 1,1-DICHLOROETHENE 000075-35-4
149 METHYLENE CHLORIDE 000075-09-2
150 BROMODICHLOROETHANE 000683-53-4
151 1,2-DICHLOROETHANE 000107-06-2
152 2,4,6-TRICHLOROPHENOL 000088-06-2
153 TETRACHLOROPHENOL 025167-83-3
154 2,4-DICHLOROPHENOL 000120-83-2
155 2,4,5-TRICHLOROPHENOL 000095-95-4
156 2-CHLOROPHENOL 000095-57-8
157 2,3,4,5-TETRACHLOROPHENOL 004901-51-3
158 2,3,5,6-TETRACHLOROPHENOL 000935-95-5
159 2,3,4,6-TETRACHLOROPHENOL 000058-90-2
160 4-CHLOROPHENOL 000106-48-9
161 CHLOROPHENOL 025167-80-0
162 2,4-DINITROPHENOL 000051-28-5
163 BIS(2-CHLOROETHYL) ETHER 000111-44-4
164 ASBESTOS 001332-21-4
165 CHRYSOTILE ASBESTOS 012001-29-5
166 AMOSITE ASBESTOS 012172-73-5
167 HEXACHLOROBENZENE 000118-74-1
168 2,4-DINITROTOLUENE 000121-14-2
169 DINITROTOLUENE 025321-14-6
170 2,6-DINITROTOLUENE 000606-20-2
171 RADIUM-226 013982-63-3
172 RADIUM 007440-14-4
173 RADIUM-228 015262-20-1
174 RADIUM-224 013233-32-4
175 ETHION 000563-12-2
176 THORIUM 007440-29-1
177 THORIUM-230 014269-63-7
178 THORIUM-228 014274-82-9
179 4,6-DINITRO-O-CRESOL 000534-52-1
180 CHLOROBENZENE 000108-90-7
181 N-NITROSODI-N-PROPYLAMINE 000621-64-7
182 1,2,3-TRICHLOROBENZENE 000087-61-6
183 POLONIUM-210 013981-52-7
184 CHLORPYRIFOS 002921-88-2
185 NEPTUNIUM-237 013994-20-2
186 CHLORDECONE 000143-50-0
187 MIREX 002385-85-5
188 S,S,S-TRIBUTYL PHOSPHOROTRITHIOATE 000078-48-8
189 BROMINE 007726-95-6
190 DICOFOL 000115-32-2
191 PARATHION 000056-38-2
192 SELENIUM 007782-49-2
193 TRICHLOROFLUOROETHANE 027154-33-2
194 TRIFLURALIN 001582-09-8
195 4,4'-METHYLENEBIS(2-CHLOROANILINE) 000101-14-4
196 PENTACHLOROBENZENE 000608-93-5
197 1,1-DICHLOROETHANE 000075-34-3
198 1,2,3,4,6,7,8,9-OCTACHLORODIBENZOFURAN 039001-02-0
199 HEPTACHLORODIBENZOFURAN 038998-75-3
200 2,3,4,7,8-PENTACHLORODIBENZOFURAN 057117-31-4
201 HEXACHLORODIBENZOFURAN 055684-94-1
202 PENTACHLORODIBENZOFURAN 030402-15-4
203 2,3,7,8-TETRACHLORODIBENZOFURAN 051207-31-9
204 DIBENZOFURANS, CHLORINATED 042934-53-2
205 1,2,3,4,6,7,8-HEPTACHLORODIBENZOFURAN 067562-39-4
206 1,2,3,7,8,9-HEXACHLORODIBENZOFURAN 072918-21-9
207 TETRACHLORODIBENZOFURAN 030402-14-3
208 1,2,3,6,7,8-HEXACHLORODIBENZOFURAN 057117-44-9
209 1,2,3,4,7,8-HEXACHLORODIBENZOFURAN 070648-26-9
210 2,3,4,6,7,8-HEXACHLORODIBENZOFURAN 060851-34-5
211 1,2,3,7,8-PENTACHLORODIBENZOFURAN 057117-41-6
212 1,2,3,4,7,8,9-HEPTACHLORODIBENZOFURAN 055673-89-7
213 1,1,2-TRICHLOROETHANE 000079-00-5
214 HEXACHLOROCYCLOPENTADIENE 000077-47-4
215 1,2-DIPHENYLHYDRAZINE 000122-66-7
216 1,2-DICHLOROETHENE, TRANS- 000156-60-5
217 1,2-DICHLOROETHYLENE 000540-59-0
218 1,2-DICHLOROETHENE, CIS- 000156-59-2
219 CARBON DISULFIDE 000075-15-0
220 PALLADIUM 007440-05-3
221 CHLOROETHANE 000075-00-3
222 ACETONE 000067-64-1
223 DIBENZOFURAN 000132-64-9
224 2,4-DIMETHYLPHENOL 000105-67-9
225 CHLOROMETHANE 000074-87-3
226 BIS(2-METHOXYETHYL) PHTHALATE 034006-76-3
227 BUTYL BENZYL PHTHALATE 000085-68-7
228 N-NITROSODIMETHYLAMINE 000062-75-9
229 1,2,4-TRICHLOROBENZENE 000120-82-1
230 N-NITROSODIPHENYLAMINE 000086-30-6
231 2-BUTANONE 000078-93-3
232 FLUORINE 007782-41-4
233 HYDROGEN FLUORIDE 007664-39-3
234 FLUORIDE ION 016984-48-8
235 AMMONIA 007664-41-7
236 COPPER 065357-62-2
237 CHLORINE DIOXIDE 010049-04-4
238 PBBs 059536-65-1
239 PBDEs 001163-19-5
240 SYNTHETIC VITREOUS FIBERS NONE

Submission of Nominations for the Evaluation Set 24 Proposed Substances: Today's notice also invites voluntary public nominations for substances not listed in this notice. Nominations are most useful if they include the nominator, including full name, title, affiliation, e-mail address, and telephone number.

ATSDR will evaluate all data and information associated with nominated substances and will determine the final list of substances to be chosen for toxicological profile development. Substances will be chosen according to ATSDR's specific guidelines for selection, found in the Selection Criteria announced in the Federal Register on May 7, 1993 (87 FR 27288).

Submission of Comments: Submit comments via e-mail at: tpcandidatecomments@cdc.gov. Please include “Set 24” in the subject line of the e-mail. Or, mail to: Commander Jessilynn B. Taylor, Division of Toxicology and Environmental Medicine, 1600 Clifton Road, MS F-62, Atlanta, GA 30333; e-mail: jbtaylor@cdc.gov.

Please ensure that your comments are submitted within the specified nomination period. Nominations received after the closing date will be marked as late and may be considered only if time and resources permit.

Dated: March 26, 2010.

Ken Rose,

Associate Director, Office of Policy, Planning and Evaluation, National Center for Environmental Health/Agency for Toxic Substances and Disease Registry.

[FR Doc. 2010-7169 Filed 3-30-10; 8:45 am]

BILLING CODE 4163-70-P

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