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The National Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) Study—New—National Center on Birth Defects and Developmental Disabilities (NCBDDD), Centers for Disease Control and Prevention (CDC).
Background and Brief Description
The Children's Health Act of 2000 mandated CDC to establish autism surveillance and research programs to address the number, incidence, correlates, and causes of autism and related disabilities. Under the provisions of this act, CDC funded 5 CADDRE centers: California Department of Health and Human Services, Colorado Department of Public Health and Environment, Johns Hopkins University, the University of Pennsylvania, and the University of North Carolina at Chapel Hill. CDC National Center on Birth Defects and Developmental Disabilities will participate as the 6th site.
The purpose of this program is to establish a multi-site, collaborative epidemiological investigation of possible causes of autism spectrum disorders. Children with autism spectrum disorders will be compared to children with other developmental problems, referred to as the neurodevelopmentally impaired group (NIC), as well as children who do not have developmental problems, referred to as the subcohort.
Data collection methods will consist of the following: (1) Medical record review of the child participant and biological mother; (2) self-administered Start Printed Page 567Questionnaires; (3) buccal cell collection; (4) a telephone interview of the biological mother and/or primary caregiver; (5) a child development evaluation (more comprehensive for case participants than for the control group participants); (6) parent-child development interview (for case participants only); (7) a physical exam of the child; (8) biological sampling of the child (blood and hair); and (9) biological sampling of the biological parents (blood only).
There are no costs to respondents other than their time. The total estimated annualized burden is 30,103 hours.
|Respondents||Number of respondents||Number of responses per respondent||Average burden per response (In hrs)||Total burden hours|
|Contact by Mail||17,610||1||10/60||2,935|
|Parent Questionnaires and biologic sample||3,456||1||235/60 (3h 55m)||13,548|
|Clinic Visit (Child Development Evaluation, physical exam, and biosamples):|
|• Case||810||1||355/60 (5h 55m)||4,793|
|• NIC||1,170||1||110/60 (1h 50m)||2,145|
|• Subcohort||1,134||1||110/60 (1h 50m)||2,079|
Dated: December 26, 2006.
Joan F. Karr,
Acting Reports Clearance Officer, Centers for Disease Control and Prevention.
[FR Doc. E6-22579 Filed 1-4-07; 8:45 am]
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