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Research Plan for Dosimetric and Toxicologic Assessment of Amphibole Asbestos Fiber-Containing Materials From Libby, MI

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Information about this document as published in the Federal Register.

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Environmental Protection Agency (EPA).


Notice of Data Availability.


This action announces a plan for a series of research projects aimed at addressing the toxicological effects and dosimetry of amphibole asbestos-contaminated vermiculite from Libby, Montana (referred to here as Libby amphibole). Although available human data establish the toxicity of asbestos, and preliminary dose response analyses for Libby amphibole have been developed, these estimates can be refined by addressing some of the key uncertainties that exist due to gaps in our understanding or lack of quantitative descriptions of internal dosimetry and toxicological effects. This planned set of projects is aimed at addressing these gaps and providing tools for quantitative characterization, including a comparative analysis of the toxicity of Libby amphibole relative to asbestos fibers and asbestos-like mineral occurrences. Other key areas of research will also inform the risk assessment, including inherent toxicity of Libby amphibole relative to other forms of asbestos and differential susceptibility, including that of different life stages. EPA conducted an internal and external review of the research plan and has documented the responses to comments.

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Stephen H. Gavett, PhD, Pulmonary Toxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development (B143-01), Environmental Protection Agency, Research Triangle Park, NC 27711; telephone number: 919-541-2555; fax number: 919-541-0026; e-mail address:

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I. General Information

A. How Can I Get Copies of the Research Plan and the Responses to Peer Review Comments?

1. Electronic Access. You may access this Federal Register document electronically through the EPA Internet under the Federal Register listings at​fedrgstr/​ or​region8/​superfund/​libby.

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Dated: September 13, 2007.

James Woolford,

Director, Office of Superfund Remediation and Technology Innovation.

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[FR Doc. E7-18521 Filed 9-18-07; 8:45 am]