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Notice

Proposed Substances To Be Evaluated for Set 24 Toxicological Profiles

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Information about this document as published in the Federal Register.

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Start Preamble

AGENCY:

Agency for Toxic Substances and Disease Registry (ATSDR), Department of Health and Human Services (HHS).

ACTION:

Request for comments on the proposed substances to be evaluated for Set 24 toxicological profiles.

SUMMARY:

This notice announces the list of proposed substances that will be evaluated for Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) Set 24 toxicological profile development. ATSDR's Division of Toxicology and Environmental Medicine is soliciting public comments on the list of proposed substances to be evaluated for toxicological profile development. ATSDR also will consider the nomination of any additional, substances, not on this list, that may have public health implications.

DATES:

Nominations must be submitted within 30 days of the publication of this notice.

ADDRESSES:

Nominations may be submitted electronically. Refer to the section Submission of Nominations (following) for the specific address.

Start Further Info

FOR FURTHER INFORMATION CONTACT:

For further information, contact: Commander Jessilynn B. Taylor, Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, 1600 Clifton Road, F-62, Atlanta, GA, 30333; telephone: (770) 488-3313; or e-mail: jbtaylor@cdc.gov.

End Further Info End Preamble Start Supplemental Information

SUPPLEMENTARY INFORMATION:

The Superfund Amendments and Reauthorization Act of 1986 (SARA) [42 U.S.C. 9601 et seq.] amended the CERCLA (or Superfund) [42 U.S.C. 9601 et seq.] by establishing certain requirements for ATSDR and the U.S. Environmental Protection Agency (EPA) with regard to hazardous substances most commonly found at facilities on the CERCLA NPL. Among these statutory requirements is a mandate for the Administrator of ATSDR to prepare toxicological profiles for each substance included on the Priority List of Hazardous Substances. This identifies 275 hazardous substances that ATSDR and EPA have determined pose the most significant potential threat to human health (http://www.atsdr.cdc.gov/​cercla/​07list.html). The availability of the revised list of the 275 priority substances was announced in the Federal Register on March 6, 2008 (73 FR 12178). For prior versions of the list of substances, see Federal Register notices dated April 17, 1987 (52 FR 12866); October 20, 1988 (53 FR 41280); October 26, 1989 (54 FR 43619); October 17, 1990 (55 FR 42067); October 17, 1991 (56 FR 52166); October 28, 1992 (57 FR 48801); February 28, 1994 (59 FR 9486); April 29, 1996 (61 FR 18744; November 17, 1997 (62 FR 61332); October 21, 1999 (64 FR 56792); October 25, 2001 (66 FR 54014); and November 7, 2003 (68 FR 63098), December 7, 2005 (70 FR 72840).Start Printed Page 16154

Proposed Substances To Be Evaluated for Set 24 Toxicological Profiles

Each year, ATSDR develops a list of substances to be considered for toxicological profile development. This list is compiled from ATSDR's Priority List of Hazardous Substances and from previously nominated substances of public health concern. The following list of 240 proposed substances will be considered for Set 24 Toxicological Profile development.

SubstancesCAS Nos.
1METHANE000074-82-8
2BROMODICHLOROETHANE000683-53-4
31,2,3-TRICHLOROBENZENE000087-61-6
4POLONIUM-210013981-52-7
5LEAD-210014255-04-0
6NEPTUNIUM-237013994-20-2
7S,S,S-TRIBUTYL PHOSPHOROTRITHIOATE000078-48-8
8BROMINE007726-95-6
9DICOLFOL000115-32-2
10PARATHIION000056-38-2
11TRICHLOROFLUOROETHANE027154-33-2
12TRIFLURALIN000152-09-8
13PENTACHLOROBENZENE000608-93-5
14TRICHLOROETHANE025323-89-1
15PALLADIUM007440-05-3
16DIBENZOFURAN000132-64-9
172,4-DIMETHYLPHENOL000105-67-9
18TETRACHLOROETHANE025322-20-7
19BIS(2-METHOXYETHYL)PHTHALATE034006-76-3
20BUTYL BENZYL PHTHALATE000085-68-7
211,2,4-TRICHLOROBENZENE000120-82-1
22NITRITE014797-65-0
23NITRATE014797-55-8
24POTASSIUM-40013966-00-2
25THORIUM-227015623-47-9
26PHORATE000298-02-2
27DIMETHOATE000060-51-5
28ACTINIUM-227014952-40-0
29STROBANE008001-50-1
304-AMINOBIPHENYL000092-67-1
31ARSINE007784-42-1
32NALED000300-76-5
33ETHOPROP013194-48-4
34CARBOPHENOTHION000786-19-6
352,4-D ACID000094-75-7
36DIURON000330-54-1
37BUTYLATE002008-41-5
38DIMETHYL FORMAMIDE000068-12-2
39DICHLOROBENZENE025321-22-6
40ETHYL ETHER000060-29-7
41DICHLOROETHANE001300-21-6
42PHOSPHINE007803-51-2
43TRICHLOROBENZENE012002-48-1
44PENTAERYTHRITOL TETRANITRATE000078-11-5
45BIS(2-ETHYLHEXYL)ADIPATE000103-23-1
46CARBAZOLE000086-74-8
47METHYL ISOBUTYL KETONE000108-10-1
48CARBARYL000063-25-2
49MERCURY007439-97-6
50METHYLMERCURY022967-92-6
51MERCURIC CHLORIDE007487-94-7
52POLYCHLORINATED BIPHENYLS001336-36-3
53AROCLOR 1254011097-69-1
54AROCLOR 1260011096-82-5
55AROCLOR 1248012672-29-6
56AROCLOR 1242053469-21-9
57AROCLOR012767-79-2
58AROCLOR 1221011104-28-2
59AROCLOR 1016012674-11-2
60AROCLOR 1232011141-16-5
61AROCLOR 1240071328-89-7
62TETRACHLOROBIPHENYL026914-33-0
63POLYCYCLIC AROMATIC HYDROCARBONS130498-29-2
64BENZO(A)PYRENE000050-32-8
65BENZO(B)FLUORANTHENE000205-99-2
66DIBENZO(A,H)ANTHRACENE000053-70-3
67BENZO(A)ANTHRACENE000056-55-3
68BENZO(K)FLUORANTHENE000207-08-9
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69BENZOFLUORANTHENE056832-73-6
70FLUORANTHENE000206-44-0
71CHRYSENE000218-01-9
72ACENAPHTHENE000083-32-9
73INDENO(1,2,3-CD)PYRENE000193-39-5
74BENZOPYRENE073467-76-2
75PHENANTHRENE000085-01-8
76PYRENE000129-00-0
77FLUORENE000086-73-7
78ANTHRACENE000120-12-7
79BENZO(A)FLUORANTHENE000203-33-8
80BENZO(GHI)PERYLENE000191-24-2
81ACENAPHTHYLENE000208-96-8
82BENZO(J)FLUORANTHENE000205-82-3
83BENZO(E)PYRENE000192-97-2
84BENZOPERYLENE011057-45-7
85BENZO(B)ANTHRACENE000092-24-0
86DIBENZ(A,J)ANTHRACENE000224-41-9
87BENZO(GHI)FLUORANTHENE000203-12-3
881-METHYLPYRENE002381-21-7
89CHLOROFORM000067-66-3
90DDT, P,P′-000050-29-3
91DDE, P,P′-000072-55-9
92DDD, P,P′-000072-54-8
93DDT, O,P′-000789-02-6
94DDD, O,P′-000053-19-0
95DDE, O,P′-003424-82-6
96TRICHLOROETHYLENE000079-01-6
97DIELDRIN000060-57-1
98ALDRIN000309-00-2
99CHLORDANE000057-74-9
100CIS-CHLORDANE005103-71-9
101TRANS-CHLORDANE005103-74-2
102OXYCHLORDANE027304-13-8
103GAMMA-CHLORDENE056641-38-4
104CHLORDANE, TECHNICAL012789-03-6
105ALPHA-CHLORDENE056534-02-2
106NONACHLOR, TRANS-039765-80-5
107NONACHLOR, CIS-005103-73-1
108CHLORDENE003734-48-3
109HEXACHLOROBUTADIENE000087-68-3
110COAL TAR CREOSOTE008001-58-9
111COAL TARS008007-45-2
112DDD, P,P′-000072-54-8
113COAL TAR PITCH065996-93-2
114BENZIDINE000092-87-5
115TOXAPHENE008001-35-2
116TETRACHLOROETHYLENE000127-18-4
1171,2-DIBROMOETHANE000106-93-4
118DISULFOTON000298-04-4
1193,3′-DICHLOROBENZIDINE000091-94-1
120ENDRIN000072-20-8
121ENDRIN KETONE053494-70-5
122ENDRIN ALDEHYDE007421-93-4
123BERYLLIUM007440-41-7
1241,2-DIBROMO-3-CHLOROPROPANE000096-12-8
125DIBROMOCHLOROPROPANE067708-83-2
126PENTACHLOROPHENOL000087-86-5
127DI-N-BUTYL PHTHALATE000084-74-2
128ENDOSULFAN000115-29-7
129ENDOSULFAN SULFATE001031-07-8
130ENDOSULFAN, ALPHA000959-98-8
131ENDOSULFAN, BETA033213-65-9
132METHOXYCHLOR000072-43-5
133METHANE000074-82-8
134TOLUENE000108-88-3
1352-HEXANONE000591-78-6
1362,3,7,8-TETRACHLORODIBENZO-P-DIOXIN001746-01-6
137HEXACHLORODIBENZO-P-DIOXIN034465-46-8
138HEPTACHLORODIBENZO-P-DIOXIN037871-00-4
139TETRACHLORODIBENZO-P-DIOXIN041903-57-5
140PENTACHLORODIBENZO-P-DIOXIN036088-22-9
1411,2,3,4,6,7,8-HEPTACHLORODIBENZO-P-DIOXIN035822-46-9
142OCTACHLORODIBENZO-P-DIOXIN003268-87-9
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1431,2,3,6,7,8-HEXACHLORODIBENZO-P-DIOXIN057653-85-7
1441,2,3,4,7,8-HEXACHLORODIBENZO-P-DIOXIN039227-28-6
1451,2,3,7,8,9-HEXACHLORODIBENZO-P-DIOXIN019408-74-3
1461,2,3,7,8-PENTACHLORODIBENZO-P-DIOXIN040321-76-4
147DI(2-ETHYLHEXYL)PHTHALATE000117-81-7
1481,1-DICHLOROETHENE000075-35-4
149METHYLENE CHLORIDE000075-09-2
150BROMODICHLOROETHANE000683-53-4
1511,2-DICHLOROETHANE000107-06-2
1522,4,6-TRICHLOROPHENOL000088-06-2
153TETRACHLOROPHENOL025167-83-3
1542,4-DICHLOROPHENOL000120-83-2
1552,4,5-TRICHLOROPHENOL000095-95-4
1562-CHLOROPHENOL000095-57-8
1572,3,4,5-TETRACHLOROPHENOL004901-51-3
1582,3,5,6-TETRACHLOROPHENOL000935-95-5
1592,3,4,6-TETRACHLOROPHENOL000058-90-2
1604-CHLOROPHENOL000106-48-9
161CHLOROPHENOL025167-80-0
1622,4-DINITROPHENOL000051-28-5
163BIS(2-CHLOROETHYL) ETHER000111-44-4
164ASBESTOS001332-21-4
165CHRYSOTILE ASBESTOS012001-29-5
166AMOSITE ASBESTOS012172-73-5
167HEXACHLOROBENZENE000118-74-1
1682,4-DINITROTOLUENE000121-14-2
169DINITROTOLUENE025321-14-6
1702,6-DINITROTOLUENE000606-20-2
171RADIUM-226013982-63-3
172RADIUM007440-14-4
173RADIUM-228015262-20-1
174RADIUM-224013233-32-4
175ETHION000563-12-2
176THORIUM007440-29-1
177THORIUM-230014269-63-7
178THORIUM-228014274-82-9
1794,6-DINITRO-O-CRESOL000534-52-1
180CHLOROBENZENE000108-90-7
181N-NITROSODI-N-PROPYLAMINE000621-64-7
1821,2,3-TRICHLOROBENZENE000087-61-6
183POLONIUM-210013981-52-7
184CHLORPYRIFOS002921-88-2
185NEPTUNIUM-237013994-20-2
186CHLORDECONE000143-50-0
187MIREX002385-85-5
188S,S,S-TRIBUTYL PHOSPHOROTRITHIOATE000078-48-8
189BROMINE007726-95-6
190DICOFOL000115-32-2
191PARATHION000056-38-2
192SELENIUM007782-49-2
193TRICHLOROFLUOROETHANE027154-33-2
194TRIFLURALIN001582-09-8
1954,4'-METHYLENEBIS(2-CHLOROANILINE)000101-14-4
196PENTACHLOROBENZENE000608-93-5
1971,1-DICHLOROETHANE000075-34-3
1981,2,3,4,6,7,8,9-OCTACHLORODIBENZOFURAN039001-02-0
199HEPTACHLORODIBENZOFURAN038998-75-3
2002,3,4,7,8-PENTACHLORODIBENZOFURAN057117-31-4
201HEXACHLORODIBENZOFURAN055684-94-1
202PENTACHLORODIBENZOFURAN030402-15-4
2032,3,7,8-TETRACHLORODIBENZOFURAN051207-31-9
204DIBENZOFURANS, CHLORINATED042934-53-2
2051,2,3,4,6,7,8-HEPTACHLORODIBENZOFURAN067562-39-4
2061,2,3,7,8,9-HEXACHLORODIBENZOFURAN072918-21-9
207TETRACHLORODIBENZOFURAN030402-14-3
2081,2,3,6,7,8-HEXACHLORODIBENZOFURAN057117-44-9
2091,2,3,4,7,8-HEXACHLORODIBENZOFURAN070648-26-9
2102,3,4,6,7,8-HEXACHLORODIBENZOFURAN060851-34-5
2111,2,3,7,8-PENTACHLORODIBENZOFURAN057117-41-6
2121,2,3,4,7,8,9-HEPTACHLORODIBENZOFURAN055673-89-7
2131,1,2-TRICHLOROETHANE000079-00-5
214HEXACHLOROCYCLOPENTADIENE000077-47-4
2151,2-DIPHENYLHYDRAZINE000122-66-7
2161,2-DICHLOROETHENE, TRANS-000156-60-5
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2171,2-DICHLOROETHYLENE000540-59-0
2181,2-DICHLOROETHENE, CIS-000156-59-2
219CARBON DISULFIDE000075-15-0
220PALLADIUM007440-05-3
221CHLOROETHANE000075-00-3
222ACETONE000067-64-1
223DIBENZOFURAN000132-64-9
2242,4-DIMETHYLPHENOL000105-67-9
225CHLOROMETHANE000074-87-3
226BIS(2-METHOXYETHYL) PHTHALATE034006-76-3
227BUTYL BENZYL PHTHALATE000085-68-7
228N-NITROSODIMETHYLAMINE000062-75-9
2291,2,4-TRICHLOROBENZENE000120-82-1
230N-NITROSODIPHENYLAMINE000086-30-6
2312-BUTANONE000078-93-3
232FLUORINE007782-41-4
233HYDROGEN FLUORIDE007664-39-3
234FLUORIDE ION016984-48-8
235AMMONIA007664-41-7
236COPPER065357-62-2
237CHLORINE DIOXIDE010049-04-4
238PBBs059536-65-1
239PBDEs001163-19-5
240SYNTHETIC VITREOUS FIBERSNONE

Submission of Nominations for the Evaluation Set 24 Proposed Substances: Today's notice also invites voluntary public nominations for substances not listed in this notice. Nominations are most useful if they include the nominator, including full name, title, affiliation, e-mail address, and telephone number.

ATSDR will evaluate all data and information associated with nominated substances and will determine the final list of substances to be chosen for toxicological profile development. Substances will be chosen according to ATSDR's specific guidelines for selection, found in the Selection Criteria announced in the Federal Register on May 7, 1993 (87 FR 27288).

Submission of Comments: Submit comments via e-mail at: tpcandidatecomments@cdc.gov. Please include “Set 24” in the subject line of the e-mail. Or, mail to: Commander Jessilynn B. Taylor, Division of Toxicology and Environmental Medicine, 1600 Clifton Road, MS F-62, Atlanta, GA 30333; e-mail: jbtaylor@cdc.gov.

Please ensure that your comments are submitted within the specified nomination period. Nominations received after the closing date will be marked as late and may be considered only if time and resources permit.

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Dated: March 26, 2010.

Ken Rose,

Associate Director, Office of Policy, Planning and Evaluation, National Center for Environmental Health/Agency for Toxic Substances and Disease Registry.

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[FR Doc. 2010-7169 Filed 3-30-10; 8:45 am]

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