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Pesticide Experimental Use Permit; Receipt of Application; Comment Request-June 2021

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Environmental Protection Agency (EPA).




This notice announces EPA's receipt of application 94614-EUP-R from GreenLight Biosciences, Inc. requesting an experimental use permit (EUP) for Ledprona (CAS No. 2433753-68-3). The Agency has determined that the permit may be of regional or national significance. Therefore, because of the potential significance, EPA is seeking comments on this application.


Comments must be received on or before July 21, 2021.


Submit your comments, identified by docket identification (ID) number and the Experimental Use Permit Number of interests as shown in the body of this document, by one of the following methods:

  • Federal eRulemaking Portal: Follow the online instructions for submitting comments. Do not submit electronically any information you consider to be Confidential Business Information (CBI) or other information whose disclosure is restricted by statute.
  • Mail: OPP Docket, Environmental Protection Agency Docket Center (EPA/DC), (28221T), 1200 Pennsylvania Ave. NW, Washington, DC 20460-0001.
  • Hand Delivery: To make special arrangements for hand delivery or delivery of boxed information, please follow the instructions at​dockets/​contacts.html.

Additional instructions on commenting or visiting the docket, along with more information about dockets generally, is available at​dockets.

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Charles Smith, Biopesticides and Pollution Prevention Division (7511P), Office of Pesticide Programs, Environmental Protection Agency, 1200 Pennsylvania Ave. NW, Washington, DC 20460-0001; main telephone number: (703) 305-7090; email address:

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I. General Information

A. Does this action apply to me?

This action is directed to the public in general. Although this action may be of particular interest to those persons who conduct or sponsor research on pesticides, the Agency has not attempted to describe all the specific entities that may be affected by this action.

B. What should I consider as I prepare my comments for EPA?

1. Submitting CBI. Do not submit this information to EPA through or email. Clearly mark the part or all of the information that you claim to be CBI. For CBI information in a disk or CD-ROM that you mail to EPA, mark the outside of the disk or CD-ROM as CBI and then identify electronically within the disk or CD-ROM the specific information that is claimed as CBI. In addition to one complete version of the comment that includes information claimed as CBI, a copy of the comment that does not contain the information claimed as CBI must be submitted for inclusion in the public docket. Information so marked will not be disclosed except in accordance with procedures set forth in 40 CFR part 2.

2. Tips for preparing your comments. When preparing and submitting your comments, see the commenting tips at​dockets/​comments.html.

3. Environmental justice. EPA seeks to achieve environmental justice, the fair treatment and meaningful involvement of any group, including minority and/or low income populations, in the development, implementation, and enforcement of environmental laws, regulations, and policies. To help address potential environmental justice issues, the Agency seeks information on any groups or segments of the population who, as a result of their location, cultural practices, or other factors, may have atypical or disproportionately high and adverse human health impacts or environmental effects from exposure to the pesticide(s) discussed in this document, compared to the general population.

II. What action is the Agency taking?

Under section 5 of the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA), 7 U.S.C. 136c, EPA can allow manufacturers to field test pesticides under development. Manufacturers are required to obtain an EUP before testing new pesticides or new uses of pesticides if they conduct experimental field tests on more than 10 acres of land or more than one surface acre of water.

Pursuant to 40 CFR 172.11(a), the Agency has determined that the following EUP application may be of regional or national significance, and therefore is seeking public comment on the EUP application:

Submitter: GreenLight Biosciences, Inc. 200 Boston Ave., Suite 1000, Medford, MA 02155.

Experimental Use Permit Number: 94614-EUP-R. Docket ID Number: EPA-HQ-OPP-2021-0270.

Pesticide Chemical: Ledprona (CAS No. 2433753-68-3).

Summary of Request: GreenLight Biosciences, Inc. is requesting an experimental use permit for the active ingredient (AI) Ledprona (CAS No. 2433753-68-3) double-stranded RNA. The purpose is to conduct large scale field trials on potatoes to better understand how the AI performs using multiple commercial application methods and equipment, as well as gathering data on efficacy and crop safety. The proposed experimental program would begin on April 1, 2022 and would go until April 1, 2023; a total of 3,700 grams of AI would be applied to 200 acres of potatoes in numerous states. The following acreage in each state will be allotted for testing with the amount of AI included in parentheses: 10 acres in Idaho (200 grams AI), 25 acres in Maine (400 grams AI), 15 acres in Michigan (200 grams AI), 15 acres in Minnesota (300 grams AI), 10 acres in New York (200 grams AI), 5 acres in North Carolina (100 grams AI), 15 acres in North Dakota (200 grams AI), 20 acres in Oregon (400 grams AI), 5 acres in Virginia (100 grams AI), 40 acres in Start Printed Page 32371Washington (800 grams AI), and 40 acres in Wisconsin (800 grams AI).

Contact: BPPD.

Following the review of the application and any comments and data received in response to this solicitation, EPA will decide whether to issue or deny the EUP request, and if issued, the conditions under which it is to be conducted. Any issuance of an EUP will be announced in the Federal Register.

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Authority: 7 U.S.C. 136 et seq.

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Dated: June 8, 2021.

Delores Barber,

Director, Information Technology and Resources Management Division, Office of Program Support.

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[FR Doc. 2021-12999 Filed 6-17-21; 4:15 am]